Federal University of São Carlos

About: Federal University of São Carlos is a education organization based out in São Carlos, Brazil. It is known for research contribution in the topics: Population & Microstructure. The organization has 16471 authors who have published 34057 publications receiving 456654 citations. The organization is also known as: UFSCar & Federal University of São Carlos.

Thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/ hydrazones: Anti - Mycobacterium tuberculosis activity and cytotoxicity

Abstract: The aim of this study was to identify a candidate drug for the development of anti-tuberculosis therapy from previously synthesized compounds based on the thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/hydrazones compounds. The minimal inhibitory concentration (MIC) of these compounds against Mycobacterium tuberculosis was determined. Their in vitro cytotoxicity to J774 cells (IC50) was determined to establish a selectivity index (SI) (SI=IC50/MIC). The best compounds were the thiosemicarbazones (2, 3 and 4) and the hydrazide/hydrazones (14, 15, 16 and 18). The results are comparable to or better than those of "first line" or "second line" drugs commonly used to treat TB, suggesting these compounds as anti-TB drug candidates.

A radicalização do debate sobre inclusão escolar no Brasil

Abstract: The debate about school inclusion in Brazil has become more and more a true collision, provoking controversy, stridency and polarization. One of the largest impacts is taking place in the arena of Special Education, in which one of the recurrent arguments is the proposition that deals with a new paradigm that should radically alter the education of children and youngsters with special educational needs in the Brazilian context. In order to "illuminate" rather than to "warm up" this debate, we intend, first, to contextualize the historical roots of the movement. Secondly, we examine the possible impacts of school inclusion and full inclusion on the Brazilian educational system. In conclusion, we discuss the thesis that we have to face the challenge of dealing with the contradiction of an imported ideology that represents an alignment to the latest fashion, but that at the same time can be one of the strategies used to overcome chronic problems of special education in the country.