Indian Institute of Technology Indore

About: Indian Institute of Technology Indore is a education organization based out in Indore, Madhya Pradesh, India. It is known for research contribution in the topics: Computer science & Chemistry. The organization has 1606 authors who have published 4803 publications receiving 66500 citations.

Cluster synchronization in multiplex networks

Abstract: We study the impact of the interaction of nodes in a layer of a multiplex network on the dynamical behavior and cluster synchronization of these nodes in the other layers. We find that nodes interactions in one layer affect the cluster synchronizability of the other layer in many different ways. While the multiplexing of a sparse network with the other sparse networks enhances the cluster synchronizability of the individual layer, multiplexing with dense networks suppresses the cluster synchronizability with the network architecture deciding the impact of the enhancement and the suppression. Additionally, at weak couplings the enhancement in the cluster synchronizability, due to multiplexing, remains of the driven type, while for strong couplings the multiplexing may lead to a transition to the self-organized mechanism. The results presented here have applicability in regulating the synchronizability of a particular layer of real-world systems having multiplex architecture.

Oncotargeting by Vesicular Stomatitis Virus (VSV): Advances in cancer therapy

Abstract: Modern oncotherapy approaches are based on inducing controlled apoptosis in tumor cells. Although a number of apoptosis-induction approaches are available, site-specific delivery of therapeutic agents still remain the biggest hurdle in achieving the desired cancer treatment benefit. Additionally, systemic treatment-induced toxicity remains a major limiting factor in chemotherapy. To specifically address drug-accessibility and chemotherapy side effects, oncolytic virotherapy (OV) has emerged as a novel cancer treatment alternative. In OV, recombinant viruses with higher replication capacity and stronger lytic properties are being considered for tumor cell-targeting and subsequent cell lysing. Successful application of OVs lies in achieving strict tumor-specific tropism called oncotropism, which is contingent upon the biophysical interactions of tumor cell surface receptors with viral receptors and subsequent replication of oncolytic viruses in cancer cells. In this direction, few viral vector platforms have been developed and some of these have entered pre-clinical/clinical trials. Among these, the Vesicular stomatitis virus (VSV)-based platform shows high promise, as it is not pathogenic to humans. Further, modern molecular biology techniques such as reverse genetics tools have favorably advanced this field by creating efficient recombinant VSVs for OV; some have entered into clinical trials. In this review, we discuss the current status of VSV based oncotherapy, challenges, and future perspectives regarding its therapeutic applications in the cancer treatment.

Measurement of the Cross Section for Electromagnetic Dissociation with Neutron Emission in Pb-Pb Collisions at root s(NN)=2.76 TeV

Abstract: The first measurement of neutron emission in electromagnetic dissociation of Pb-208 nuclei at the LHC is presented. The measurement is performed using the neutron zero degree calorimeters of the ALICE experiment, which detect neutral particles close to beam rapidity. The measured cross sections of single and mutual electromagnetic dissociation of Pb nuclei at root s(NN) = 2.76 TeV with neutron emission are sigma(singleEMD) = 187.4 +/- 0.2(stat)(-11.2)(+13.2) (syst) b and sigma(mutualEMD) = 5. 7 +/- 0.1(stat) +/- 0.4(syst) b, respectively. The experimental results are compared to the predictions from a relativistic electromagnetic dissociation model. DOI: 10.1103/PhysRevLett.109.252302