Indian Institute of Technology Indore

About: Indian Institute of Technology Indore is a education organization based out in Indore, Madhya Pradesh, India. It is known for research contribution in the topics: Computer science & Chemistry. The organization has 1606 authors who have published 4803 publications receiving 66500 citations.

Multiplicity Dependence of Non-extensive Parameters for Strange and Multi-Strange Particles in Proton-Proton Collisions at $\sqrt{s}= 7$ TeV at the LHC

Abstract: The transverse momentum ($p_{\rm T}$) spectra in proton-proton collisions at $\sqrt{s}$ = 7 TeV, measured by the ALICE experiment at the LHC are analyzed with a thermodynamically consistent Tsallis distribution. The information about the freeze-out surface in terms of freeze-out volume, temperature and the non-extenisivity parameter, $q$, for $K^{0}_{S}$, $\Lambda+\bar{\Lambda}$, $\Xi^{-}+\bar{\Xi}^{+}$ and $\Omega^{-}+\bar{\Omega}^{+}$ are extracted by fitting the $p_{\rm T}$ spectra with Tsallis distribution function. The freeze-out parameters of these particles are studied as a function of charged particle multiplicity density ($dN_{ch}/d\eta$). In addition, we also study these parameters as a function of particle mass to see any possible mass ordering. The strange and multi-strange particles show mass ordering in volume, temperature, non-extensive parameter and also a strong dependence on multiplicity classes. It is observed that with increase in particle multiplicity, the non-extensivity parameter, $q$ decreases, which indicates the tendency of the produced system towards thermodynamic equilibration. The increase in strange particle multiplicity is observed to be due to the increase of temperature and not to the size of the freeze-out volume.

Polyphenolic flavonoid (Myricetin) upregulated proteasomal degradation mechanisms: Eliminates neurodegenerative proteins aggregation.

Abstract: Major neurodegenerative disorders are characterized by the formation of misfolded proteins aggregates inside or outside the neuronal cells. Previous studies suggest that aberrant proteins aggregates play a critical role in protein homeostasis imbalance and failure of protein quality control (PQC) mechanism, leading to disease conditions. However, we still do not understand the precise mechanisms of PQC failure and cellular dysfunctions associated with neurodegenerative diseases caused by the accumulation of protein aggregates. Here, we show that Myricetin, a flavonoid, can eliminate various abnormal proteins from the cellular environment via modulating endogenous levels of Hsp70 chaperone and quality control (QC)-E3 ubiquitin ligase E6-AP. We have observed that Myricetin treatment suppresses the aggregation of different aberrant proteins. Myricetin also enhances the elimination of various toxic neurodegenerative diseases associated proteins from the cells, which could be reversed by the addition of putative proteasome inhibitor (MG132). Remarkably, Myricetin can also stabilize E6-AP and reduce the misfolded proteins inclusions, which further alleviates cytotoxicity. Taken together these findings suggested that new mechanistic and therapeutic insights based on small molecules mediated regulation of disturbed protein quality control mechanism, which may result in the maintenance of the state of proteostasis.

Pyridine Bridging Diphenylamine-Carbazole with Linking Topology as Rational Hole Transporter for Perovskite Solar Cells Fabrication

Abstract: Developing cost-effective and rational hole transporting materials is critical for fabricating high-performance perovskite solar cells (PSCs) and to promote their commercial endeavor. We have desig...