Northwestern University

About: Northwestern University is a education organization based out in Evanston, Illinois, United States. It is known for research contribution in the topics: Population & Medicine. The organization has 75430 authors who have published 188857 publications receiving 9463252 citations. The organization is also known as: Northwestern & NU.

Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy.

Abstract: One of the common neurological complications in patients with the acquired immune deficiency syndrome (AIDS) is a subacute encephalopathy with progressive dementia. By using the techniques of cocultivation for virus isolation, in situ hybridization, immunocytochemistry, and transmission electron microscopy, the identity of an important cell type that supports replication of the AIDS retrovirus in brain tissue was determined in two affected individuals. These cells were mononucleated and multinucleated macrophages that actively synthesized viral RNA and produced progeny virions in the brains of the patients. Infected brain macrophages may serve as a reservoir for virus and as a vehicle for viral dissemination in the infected host.

Nonlocal damage theory

Abstract: In the usual local finite element analysis, strain softening causes spurious mesh sensitivity and incorrect convergence when the element is refined to vanishing size. In a previous continuum formulation, these incorrect features were overcome by the imbricate nonlocal continuum, which, however, introduced some unnecessary computational complications due to the fact that all response was treated as nonlocal. The key idea of the present nonlocal damage theory is to subject to nonlocal treatment only those variables that control strain softening, and to treat the elastic part of the strain as local. The continuum damage mechanics formulation, convenient for separating the nonlocal treatment of damage from the local treatment of elastic behavior, is adopted in the present work. The only required modification is to replace the usual local damage energy release rate with its spatial average over the representative volume of the material whose size is a characteristic of the material. Avoidance of spurious mesh ...

Reconfigurable computing: a survey of systems and software

Abstract: Due to its potential to greatly accelerate a wide variety of applications, reconfigurable computing has become a subject of a great deal of research. Its key feature is the ability to perform computations in hardware to increase performance, while retaining much of the flexibility of a software solution. In this survey, we explore the hardware aspects of reconfigurable computing machines, from single chip architectures to multi-chip systems, including internal structures and external coupling. We also focus on the software that targets these machines, such as compilation tools that map high-level algorithms directly to the reconfigurable substrate. Finally, we consider the issues involved in run-time reconfigurable systems, which reuse the configurable hardware during program execution.

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

Abstract: Intra-abdominal tumors, such as ovarian cancer, have a clear predilection for metastasis to the omentum, an organ primarily composed of adipocytes. Currently, it is unclear why tumor cells preferentially home to and proliferate in the omentum, yet omental metastases typically represent the largest tumor in the abdominal cavities of women with ovarian cancer. We show here that primary human omental adipocytes promote homing, migration and invasion of ovarian cancer cells, and that adipokines including interleukin-8 (IL-8) mediate these activities. Adipocyte-ovarian cancer cell coculture led to the direct transfer of lipids from adipocytes to ovarian cancer cells and promoted in vitro and in vivo tumor growth. Furthermore, coculture induced lipolysis in adipocytes and β-oxidation in cancer cells, suggesting adipocytes act as an energy source for the cancer cells. A protein array identified upregulation of fatty acid-binding protein 4 (FABP4, also known as aP2) in omental metastases as compared to primary ovarian tumors, and FABP4 expression was detected in ovarian cancer cells at the adipocyte-tumor cell interface. FABP4 deficiency substantially impaired metastatic tumor growth in mice, indicating that FABP4 has a key role in ovarian cancer metastasis. These data indicate adipocytes provide fatty acids for rapid tumor growth, identifying lipid metabolism and transport as new targets for the treatment of cancers where adipocytes are a major component of the microenvironment.