Institution
Sichuan University
Education•Chengdu, China•
About: Sichuan University is a education organization based out in Chengdu, China. It is known for research contribution in the topics: Catalysis & Population. The organization has 107623 authors who have published 102844 publications receiving 1612131 citations. The organization is also known as: Sìchuān Dàxué.
Topics: Catalysis, Population, Medicine, Cancer, Chemistry
Papers published on a yearly basis
Papers
More filters
••
Capital Medical University1, Xi'an Jiaotong University2, Huazhong University of Science and Technology3, Fudan University4, China Medical University (PRC)5, Guangzhou Medical University6, Zhejiang University7, Sichuan University8, Peking University9, Peking Union Medical College10, China-Japan Friendship Hospital11, Clinical Trial Service Unit12, National Institutes of Health13, Tulane University14
TL;DR: The national prevalence of asthma in a representative sample of the Chinese population was 4·2% (95% CI 3·1-5·6), representing 45·7 million Chinese adults, and smoking, childhood pneumonia or bronchitis, parental history of respiratory disease, and low education attainment were associated with prevalent asthma.
262 citations
••
TL;DR: In this paper, the catalysts were used in the catalytic conversion of glucose to 5-hydroxymethylfurfural, achieving a yield of 47.6% within 4h at 403 K over SO 4 2− /ZrO 2 −Al 2 O 3 with Zr−Al mole ratio of 1:1.
261 citations
••
TL;DR: This study proposed a complex KIAA1429-GATA3 regulatory model based on m6A modification and provided insights into the epi-transcriptomic dysregulation in hepatocarcinogenesis and metastasis.
Abstract: N6-methyladenosine (m6A) modification, the most abundant internal methylation of eukaryotic RNA transcripts, is critically implicated in RNA processing. As the largest known component in the m6A methyltransferase complex, KIAA1429 plays a vital role in m6A methylation. However, its function and mechanism in hepatocellular carcinoma (HCC) remain poorly defined. Quantitative PCR, western blot and immunohistochemistry were used to measure the expression of KIAA1429 in HCC. The effects of KIAA1429 on the malignant phenotypes of hepatoma cells were examined in vitro and in vivo. MeRIP-seq, RIP-seq and RNA-seq were performed to identify the target genes of KIAA1429. KIAA1429 was considerably upregulated in HCC tissues. High expression of KIAA1429 was associated with poor prognosis among HCC patients. Silencing KIAA1429 suppressed cell proliferation and metastasis in vitro and in vivo. GATA3 was identified as the direct downstream target of KIAA1429-mediated m6A modification. KIAA1429 induced m6A methylation on the 3′ UTR of GATA3 pre-mRNA, leading to the separation of the RNA-binding protein HuR and the degradation of GATA3 pre-mRNA. Strikingly, a long noncoding RNA (lncRNA) GATA3-AS, transcribed from the antisense strand of the GATA3 gene, functioned as a cis-acting element for the preferential interaction of KIAA1429 with GATA3 pre-mRNA. Accordingly, we found that the tumor growth and metastasis driven by KIAA1429 or GATA3-AS were mediated by GATA3. Our study proposed a complex KIAA1429-GATA3 regulatory model based on m6A modification and provided insights into the epi-transcriptomic dysregulation in hepatocarcinogenesis and metastasis.
261 citations
••
TL;DR: In this article, the mechanical properties, thermal stability, light barrier properties, swelling behavior as well as water vapor permeability of gelatin-carboxymethyl cellulose (DCMC) films are investigated.
261 citations
••
TL;DR: The data suggested that the SRM-B, with different particular pore sizes, could serve as a kind of promising wound dressing, which could significantly enhance wound re-epithelialization and contraction, which accelerated the wound healing.
261 citations
Authors
Showing all 108474 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jie Zhang | 178 | 4857 | 221720 |
Robin M. Murray | 171 | 1539 | 116362 |
Xiang Zhang | 154 | 1733 | 117576 |
Rui Zhang | 151 | 2625 | 107917 |
Xiaoyuan Chen | 149 | 994 | 89870 |
Yi Yang | 143 | 2456 | 92268 |
Xinliang Feng | 134 | 721 | 73033 |
Chuan He | 130 | 584 | 66438 |
Lei Zhang | 130 | 2312 | 86950 |
Jian Zhou | 128 | 3007 | 91402 |
Shaobin Wang | 126 | 872 | 52463 |
Yi Xie | 126 | 745 | 62970 |
Pak C. Sham | 124 | 866 | 100601 |
Wei Chen | 122 | 1946 | 89460 |
Bo Wang | 119 | 2905 | 84863 |