Sichuan University

About: Sichuan University is a education organization based out in Chengdu, China. It is known for research contribution in the topics: Catalysis & Population. The organization has 107623 authors who have published 102844 publications receiving 1612131 citations. The organization is also known as: Sìchuān Dàxué.

Salivary Glands: Potential Reservoirs for COVID-19 Asymptomatic Infection.

Abstract: According to a latest report on coronavirus disease 2019 (COVID-19), authors had drawn attention to dental risk, in which asymptomatic patients had been mentioned many times (Meng et al. 2020). Previously, researchers have shown the role of oral mucosa in COVID-19 infection (Xu, Zhong, et al. 2020). We would like to draw attention to salivary glands in the epidemic process of asymptomatic infections.

Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy

Abstract: The therapeutic outcome of photothermal therapy (PTT) remains impeded by the transparent depth of light. Combining PTT with immunotherapy provides strategies to solve this problem. Regulating metabolism-related enzymes is a promising strategy to stimulate immune response. Here, a nanosystem (NLG919/IR780 micelles) with the properties of photothermal conversion and regulation of the tryptophan metabolic pathway is used to suppress the growth of the tumor margin beyond effective PTT and promote tumor PTT and immunotherapy. It is revealed that mild heat treatment promotes the growth of the tumor margin beyond effective PTT for the upregulation of heat shock protein (HSP), indoleamine 2,3-dioxygenase (IDO), and programmed death-ligand 1 (PD-L1). The NLG919/IR780 micelles can effectively inhibit the activity of IDO but do not affect the level of IDO expression. NLG919/IR780 micelles can effectively accumulate in the tumor and can migrate to lymph nodes and the lymphatic system. In vivo antitumor studies reveal that NLG919/IR780 micelles effectively suppress the growth of tumor margin following PTT in primary tumors. NLG919/IR780 micelle-mediated PTT and IDO inhibition further stimulate the activation of T lymphocytes, inhibiting the growth of distal tumors (abscopal effect). The results demonstrate that the NLG919/IR780 micelles combine PTT and immunotherapy and suppress the tumor margin as well as distal tumor growth post photothermal therapy.

Cellulose composite aerogel for highly efficient electromagnetic interference shielding

Abstract: An ultra-light and highly conductive cellulose composite aerogel was fabricated by a simple, efficient and environmentally benign strategy. The scaffold structure was well designed from nanofibrillar networks to nanosheet networks by controlling the concentration of cellulose in the sodium hydroxide/urea solution. The obtained conductive aerogel was first reported as an electromagnetic interference shielding material; it exhibits an electromagnetic interference (EMI) shielding effectiveness of ∼20.8 dB and a corresponding specific EMI shielding effectiveness as high as ∼219 dB cm3 g−1 with microwave absorption as the dominant EMI shielding mechanism in the microwave frequency range of 8.2–12.4 GHz at a density of as low as 0.095 g cm−3. This result demonstrates that this type of green conductive aerogel has the potential to be used as lightweight shielding material against electromagnetic radiation, especially for aircraft and spacecraft applications.

Observation of a near-threshold enhancement in the pp mass spectrum from radiative J/psi-->gammapp decays.

Abstract: We observe a narrow enhancement near 2m(p) in the invariant mass spectrum of pp pairs from radiative J/psi-->gammapp decays. No similar structure is seen in J/psi-->pi(0)pp decays. The results are based on an analysis of a 58 x 10(6) event sample of J/psi decays accumulated with the BESII detector at the Beijing electron-positron collider. The enhancement can be fit with either an S- or P-wave Breit-Wigner resonance function. In the case of the S-wave fit, the peak mass is below 2m(p) at M=1859(+3)(-10) (stat)+5-25(syst) MeV/c(2) and the total width is Gamma<30 MeV/c(2) at the 90% confidence level. These mass and width values are not consistent with the properties of any known particle.