Sichuan University

About: Sichuan University is a education organization based out in Chengdu, China. It is known for research contribution in the topics: Catalysis & Population. The organization has 107623 authors who have published 102844 publications receiving 1612131 citations. The organization is also known as: Sìchuān Dàxué.

Targeting mTOR for cancer therapy

Abstract: Mechanistic target of rapamycin (mTOR) is a protein kinase regulating cell growth, survival, metabolism, and immunity. mTOR is usually assembled into several complexes such as mTOR complex 1/2 (mTORC1/2). In cooperation with raptor, rictor, LST8, and mSin1, key components in mTORC1 or mTORC2, mTOR catalyzes the phosphorylation of multiple targets such as ribosomal protein S6 kinase β-1 (S6K1), eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1), Akt, protein kinase C (PKC), and type-I insulin-like growth factor receptor (IGF-IR), thereby regulating protein synthesis, nutrients metabolism, growth factor signaling, cell growth, and migration. Activation of mTOR promotes tumor growth and metastasis. Many mTOR inhibitors have been developed to treat cancer. While some of the mTOR inhibitors have been approved to treat human cancer, more mTOR inhibitors are being evaluated in clinical trials. Here, we update recent advances in exploring mTOR signaling and the development of mTOR inhibitors for cancer therapy. In addition, we discuss the mechanisms underlying the resistance to mTOR inhibitors in cancer cells.

International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management

Abstract: Sarcopenia, defined as an age-associated loss of skeletal muscle function and muscle mass, occurs in approximately 6 - 22 % of older adults. This paper presents evidence-based clinical practice guidelines for screening, diagnosis and management of sarcopenia from the task force of the International Conference on Sarcopenia and Frailty Research (ICSFR). To develop the guidelines, we drew upon the best available evidence from two systematic reviews paired with consensus statements by international working groups on sarcopenia. Eight topics were selected for the recommendations: (i) defining sarcopenia; (ii) screening and diagnosis; (iii) physical activity prescription; (iv) protein supplementation; (v) vitamin D supplementation; (vi) anabolic hormone prescription; (vii) medications under development; and (viii) research. The ICSFR task force evaluated the evidence behind each topic including the quality of evidence, the benefitharm balance of treatment, patient preferences/values, and cost-effectiveness. Recommendations were graded as either strong or conditional (weak) as per the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach. Consensus was achieved via one face-to-face workshop and a modified Delphi process. We make a conditional recommendation for the use of an internationally accepted measurement tool for the diagnosis of sarcopenia including the EWGSOP and FNIH definitions, and advocate for rapid screening using gait speed or the SARC-F. To treat sarcopenia, we strongly recommend the prescription of resistance-based physical activity, and conditionally recommend protein supplementation/a protein-rich diet. No recommendation is given for Vitamin D supplementation or for anabolic hormone prescription. There is a lack of robust evidence to assess the strength of other treatment options.

Review on auxetic materials

Abstract: Although a negative Poisson's ratio (that is, a lateral extension in response to stretching) is not forbidden by thermodynamics, for almost all common materials the Poisson's ratio is positive. In 1987, Lakes first discovered negative Poisson's ratio effect in polyurethane (PU) foam with re-entrant structures, which was named anti-rubber, auxetic, and dilatational by later researchers. In this paper, the term 'auxetic' will be used. Since then, investigation on the auxetic materials has held major interest, focusing on finding more materials with negative Poisson's ratio, and on examining the mechanisms, properties and applications. Therefore, more materials were found to have the counter-intuitive effect of auxeticity due to different structural or microstructrual mechanisms. The present article reviews the latest advances in auxetic materials, their structural mechanisms, performance and applications.

Study on rock mechanics in deep mining engineering

Abstract: The rock mechanics problems caused by the deep mining engineering are the focuses in the fields of mining engineering and rock mechanics. A lot of achievements were obtained by scholars through theoretical studyl,aboratory test,and in-site test. Based on the previous studies of authorst,he main differences in engineering mechanics for the characters of rock mass between shallow mining and deep mining are summarized. They are complicated as follows:(1) mining environments with three“high”and one“disturbance”—high ground stress, high earth temperature,high karst water pressure,and mining disturbance;(2) five transform features of mechanical characters;(3) four changes of coal mine types;and (4) six representing types of engineering hazards. By the detailed research on the nonlinear mechanical characters of engineering rock mass in deep mining under complicated geology mechanical environmentsi;t is pointed out that the mechanical system,which is subordinated to engineering rockmass at depth,is the nonlinear mechanical system,but not the linear mechanics system subordinated to engineering rock mass at shallow. The classic theory,methods,and technology are partly or most entirely invalid. So,it is very important to study the basic theory of rock mechanics in deep engineering.