Institution
St. Jude Children's Research Hospital
Healthcare•Memphis, Tennessee, United States•
About: St. Jude Children's Research Hospital is a healthcare organization based out in Memphis, Tennessee, United States. It is known for research contribution in the topics: Population & Virus. The organization has 9344 authors who have published 19233 publications receiving 1233399 citations. The organization is also known as: St. Jude Children's Hospital & St. Jude Hospital.
Topics: Population, Virus, Cancer, Influenza A virus, Leukemia
Papers published on a yearly basis
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TL;DR: The membrane-distal region, which contains the major sites of tyrosineosphorylation, is required for phosphorylation of SHC and p85, not for mitogenesis, thus allowing functional dissection of the signaling pathways activated by cytokines.
904 citations
Journal Article•
TL;DR: The premature induction of apoptosis in cells harboring a deregulated c-myc gene suggests that apoptosis may be an important mechanism in the elimination of hematopoietic cells Harboring mutations, such as constitutive c- myc expression, which imbalance normal cell cycle regulatory controls.
Abstract: In the murine interleukin 3 (IL-3)-dependent myeloid cell line 32D, down-regulation of c-myc and ornithine decarboxylase (ODC) expression is an immediate response to IL-3 deprivation. This is followed by an accumulation of cells in the G1 phase of the cell cycle, and eventual cell death. However, clones of 32D cells harboring an expression vector which constitutively expresses murine c-myc did not down-regulate ODC transcripts in response to IL-3 withdrawal, and they failed to G1 arrest. Moreover, in contrast to control cultures in which the majority of death occurred following G1 arrest, c-myc clones rapidly initiated a program of cell death characteristic of apoptosis following IL-3 deprivation, and their subsequent loss of viability occurred with accelerated kinetics. The premature induction of apoptosis in cells harboring a deregulated c-myc gene suggests that apoptosis may be an important mechanism in the elimination of hematopoietic cells harboring mutations, such as constitutive c-myc expression, which imbalance normal cell cycle regulatory controls.
903 citations
TL;DR: The data suggest that abnormal activation of the PI3K/AKT pathway in specific neuronal populations can underlie macrocephaly and behavioral abnormalities reminiscent of certain features of human ASD.
898 citations
TL;DR: In this article, a cyclin D-regulated catalytic subunit that acts as an Rb (but not H1) kinase has been identified, which is called p34 PSK-J3.
887 citations
TL;DR: It is reported that Puma is essential for hematopoietic cell death triggered by ionizing radiation, deregulated c-Myc expression, and cytokine withdrawal, and required for IR-induced death throughout the developing nervous system and accounts for nearly all of the apoptotic activity attributed to p53 under these conditions.
883 citations
Authors
Showing all 9410 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Richard A. Flavell | 231 | 1328 | 205119 |
| David Baltimore | 203 | 876 | 162955 |
| John C. Reed | 190 | 891 | 164382 |
| Joan Massagué | 189 | 408 | 149951 |
| Stuart H. Orkin | 186 | 715 | 112182 |
| Douglas R. Green | 182 | 661 | 145944 |
| Richard K. Wilson | 173 | 463 | 260000 |
| Todd R. Golub | 164 | 422 | 201457 |
| Robert G. Webster | 158 | 843 | 90776 |
| Elaine R. Mardis | 156 | 485 | 226700 |
| David Cella | 156 | 1258 | 106402 |
| Rafi Ahmed | 146 | 633 | 93190 |
| Ching-Hon Pui | 145 | 805 | 72146 |
| Yoshihiro Kawaoka | 139 | 883 | 75087 |
| Seth M. Steinberg | 137 | 936 | 80148 |