Institution
Stockholm University
Education•Stockholm, Sweden•
About: Stockholm University is a education organization based out in Stockholm, Sweden. It is known for research contribution in the topics: Population & Context (language use). The organization has 21052 authors who have published 62567 publications receiving 2725859 citations. The organization is also known as: University of Stockholm & Stockholms universitet.
Topics: Population, Context (language use), Galaxy, Supernova, Catalysis
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TL;DR: Detailed statistical analyses of integral membrane proteins of the helix‐bundle class from eubacterial, archaean, and eukaryotic organisms for which genome‐wide sequence data are available suggest that uni‐cellular organisms appear to prefer proteins with 6 and 12 transmembrane segments, whereas Caenorhabditis elegans and Homo sapiens have a slight preference for proteins with seven transmemBRane segments.
Abstract: We have carried out detailed statistical analyses of integral membrane proteins of the helix-bundle class from eubacterial, archaean, and eukaryotic organisms for which genome-wide sequence data are available. Twenty to 30% of all ORFs are predicted to encode membrane proteins, with the larger genomes containing a higher fraction than the smaller ones. Although there is a general tendency that proteins with a smaller number of transmembrane segments are more prevalent than those with many, uni-cellular organisms appear to prefer proteins with 6 and 12 transmembrane segments, whereas Caenorhabditis elegans and Homo sapiens have a slight preference for proteins with seven transmembrane segments. In all organisms, there is a tendency that membrane proteins either have many transmembrane segments with short connecting loops or few transmembrane segments with large extra-membraneous domains. Membrane proteins from all organisms studied, except possibly the archaeon Methanococcus jannaschii, follow the so-called "positive-inside" rule; i.e., they tend to have a higher frequency of positively charged residues in cytoplasmic than in extra-cytoplasmic segments.
1,519 citations
Valentina Escott-Price1, Céline Bellenguez2, Li-San Wang3, Seung Hoan Choi4 +191 more•Institutions (67)
TL;DR: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimers disease.
Abstract: Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This s ...
1,518 citations
University of Adelaide1, University of Wisconsin-Madison2, Ghent University3, University of Canterbury4, University of Geneva5, Humboldt University of Berlin6, University of California, Irvine7, University of Mainz8, University of California, Berkeley9, Ohio State University10, Université libre de Bruxelles11, Ruhr University Bochum12, University of Wuppertal13, University of Maryland, College Park14, University of Kansas15, Lawrence Berkeley National Laboratory16, RWTH Aachen University17, Uppsala University18, University of Alberta19, Stockholm University20, Vrije Universiteit Brussel21, University of Bonn22, École Polytechnique Fédérale de Lausanne23, Georgia Institute of Technology24, Pennsylvania State University25, Technical University of Dortmund26, Southern University and A&M College27
TL;DR: The presence of a high-energy neutrino flux containing the most energetic neutrinos ever observed is revealed, including 28 events at energies between 30 and 1200 TeV, although the origin of this flux is unknown and the findings are consistent with expectations for a neutRino population with origins outside the solar system.
Abstract: We report on results of an all-sky search for high-energy neutrino events interacting within the IceCube neutrino detector conducted between May 2010 and May 2012. The search follows up on the previous detection of two PeV neutrino events, with improved sensitivity and extended energy coverage down to about 30 TeV. Twenty-six additional events were observed, substantially more than expected from atmospheric backgrounds. Combined, both searches reject a purely atmospheric origin for the 28 events at the 4 sigma level. These 28 events, which include the highest energy neutrinos ever observed, have flavors, directions, and energies inconsistent with those expected from the atmospheric muon and neutrino backgrounds. These properties are, however, consistent with generic predictions for an additional component of extraterrestrial origin.
1,490 citations
TL;DR: In this article, balanced budget redistribution between socioeconomic groups is modeled as the outcome of electoral competition between two political parties, and a sufficient condition for existence is given, requiring that there be enough heterogeneity with respect to party preferences in the electorate.
Abstract: This paper models balanced-budget redistribution between socio-economic groups as the outcome of electoral competition between two political parties. Equilibrium is unique in the present model, and a sufficient condition for existence is given, requiring that there be enough ‘stochastic heterogeneity’ with respect to party preferences in the electorate. The validity of Hotelling's ‘principle of minimum differentiation’, and of ‘Director's Law’, are examined under alternative hypotheses concerning administrative costs of redistributions, and voter's possibilities both of abstaining from voting and of becoming campaign activists for one of the parties. The policy strategy of expected-plurality maximization is contrasted with the strategy of maximizing the probability of gaining a plurality. Incomes are fixed and known, so lump-sum taxation is feasible. However, constraints on tax/transfer differentiation between individuals are permitted in the analysis.
1,486 citations
TL;DR: Promiscuous individuals are the vulnerable nodes to target in safe-sex campaigns.
Abstract: This article analyses data gathered in a 1996 Swedish survey of sexual behavior of 4781 Swedes aged 18-74 years. The authors state that the most important finding is the scale-free nature of the connectivity of an objectively defined non-professional social network. The possibility that the web of sexual contacts has a scale-free structure indicates that strategic targeting of safe-sex education campaigns t o those individuals with a large number of partners may significantly reduce the propagation of sexually transmitted diseases.
1,479 citations
Authors
Showing all 21326 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Hongjie Dai | 197 | 570 | 182579 |
| Hyun-Chul Kim | 176 | 4076 | 183227 |
| Richard S. Ellis | 169 | 882 | 136011 |
| Stanley B. Prusiner | 168 | 745 | 97528 |
| Anders Björklund | 165 | 769 | 84268 |
| Yang Yang | 164 | 2704 | 144071 |
| Tomas Hökfelt | 158 | 1033 | 95979 |
| Bengt Winblad | 153 | 1240 | 101064 |
| Zhenwei Yang | 150 | 956 | 109344 |
| Marvin Johnson | 149 | 1827 | 119520 |
| Jan-Åke Gustafsson | 147 | 1058 | 98804 |
| Markus Ackermann | 146 | 610 | 71071 |
| Hans-Olov Adami | 145 | 908 | 83473 |
| Markku Kulmala | 142 | 1487 | 85179 |
| Kjell Fuxe | 142 | 1479 | 89846 |