University of Arizona

About: University of Arizona is a education organization based out in Tucson, Arizona, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 63805 authors who have published 155998 publications receiving 6854915 citations. The organization is also known as: UA & U of A.

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

Abstract: Objective The inner mucus layer in mouse colon normally separates bacteria from the epithelium. Do humans have a similar inner mucus layer and are defects in this mucus layer a common denominator for spontaneous colitis in mice models and ulcerative colitis (UC)? Methods and results The colon mucus layer from mice deficient in Muc2 mucin, Core 1 O -glycans, Tlr5, interleukin 10 (IL-10) and Slc9a3 (Nhe3) together with that from dextran sodium sulfate-treated mice was immunostained for Muc2, and bacterial localisation in the mucus was analysed. All murine colitis models revealed bacteria in contact with the epithelium. Additional analysis of the less inflamed IL-10 −/− mice revealed a thicker mucus layer than wild-type, but the properties were different, as the inner mucus layer could be penetrated both by bacteria in vivo and by fluorescent beads the size of bacteria ex vivo. Clear separation between bacteria or fluorescent beads and the epithelium mediated by the inner mucus layer was also evident in normal human sigmoid colon biopsy samples. In contrast, mucus on colon biopsy specimens from patients with UC with acute inflammation was highly penetrable. Most patients with UC in remission had an impenetrable mucus layer similar to that of controls. Conclusions Normal human sigmoid colon has an inner mucus layer that is impenetrable to bacteria. The colon mucus in animal models that spontaneously develop colitis and in patients with active UC allows bacteria to penetrate and reach the epithelium. Thus colon mucus properties can be modulated, and this suggests a novel model of UC pathophysiology.

Strong asymptotics of orthogonal polynomials with respect to exponential weights

Abstract: We consider asymptotics of orthogonal polynomials with respect to weights w(x)dx= e Q(x) dx on the real line, where Q(x)=∑ 2m k=0 qkx k , q2m> 0, denotes a polynomial of even order with positive leading coefficient. The orthogonal polynomial problem is formulated as a Riemann-Hilbert problem following [22, 23]. We employ the steepest-descent-type method introduced in [18] and further developed in [17, 19] in order to obtain uniform Plancherel-Rotach-type asymptotics in the entire complex plane, as well as asymptotic formulae for the zeros, the leading coefficients, and the recurrence coefficients of the orthogonal polynomials. c 1999 John Wiley & Sons, Inc.

Focus on psychometrics. Aspects of item analysis.

Abstract: During the course of instrument development, investigators are faced with the challenge of developing a psychometrically sound instrument that has a minimal number of items or components. Although instrument developers may encounter specific problems in relation to different types of tests, there are three areas of concern that are frequently encountered. These concerns relate to (a) instrument length, (b) scale homogeneity, and (c) instrument sensitivity. The purpose of this article is to discuss selected aspects of item analysis in relationship to these three commonly encountered and interrelated areas of concern.

3D-HST: a wide-field grism spectroscopic survey with the Hubble Space Telescope

Abstract: We present 3D-HST, a near-infrared spectroscopic Treasury program with the Hubble Space Telescope for studying the physical processes that shape galaxies in the distant universe. 3D-HST provides rest-frame optical spectra for a sample of ∼7000 galaxies at 1 < z < 3.5, the epoch when ∼60% of all star formation took place, the number density of quasars peaked, the first galaxies stopped forming stars, and the structural regularity that we see in galaxies today must have emerged. 3D-HST will cover three quarters (625 arcmin^2) of the CANDELS Treasury survey area with two orbits of primary WFC3/G141 grism coverage and two to four orbits with the ACS/G800L grism in parallel. In the IR, these exposure times yield a continuum signal-to-noise ratio of ∼5 per resolution element at H_140 ∼ 23.1 and a 5σ emission-line sensitivity of ∼5 × 10^(−17) erg s^−1 cm^(−2) for typical objects, improving by a factor of ∼2 for compact sources in images with low sky background levels. The WFC3/G141 spectra provide continuous wavelength coverage from 1.1 to 1.6μm at a spatial resolution of ∼0."13, which, combined with their depth, makes them a unique resource for studying galaxy evolution. We present an overview of the preliminary reduction and analysis of the grism observations, including emission-line and redshift measurements from combined fits to the extracted grism spectra and photometry from ancillary multi-wavelength catalogs. The present analysis yields redshift estimates with a precision of σ(z) = 0.0034(1 + z), or σ(v) ≈ 1000 km s^(−1). We illustrate how the generalized nature of the survey yields near-infrared spectra of remarkable quality for many different types of objects, including a quasar at z = 4.7, quiescent galaxies at z ∼ 2, and the most distant T-type brown dwarf star known. The combination of the CANDELS and 3D-HST surveys will provide the definitive imaging and spectroscopic data set for studies of the 1 < z < 3.5 universe until the launch of the James Webb Space Telescope.