University of Arizona

About: University of Arizona is a education organization based out in Tucson, Arizona, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 63805 authors who have published 155998 publications receiving 6854915 citations. The organization is also known as: UA & U of A.

Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma

Abstract: Diffuse large B cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma. In the least curable (ABC) subtype of DLBCL, survival of the malignant cells is dependent on constitutive activation of the nuclear factor-kappaB (NF-kappaB) signaling pathway. In normal B cells, antigen receptor-induced NF-kappaB activation requires CARD11, a cytoplasmic scaffolding protein. To determine whether CARD11 contributes to tumorigenesis, we sequenced the CARD11 gene in human DLBCL tumors. We detected missense mutations in 7 of 73 ABC DLBCL biopsies (9.6%), all within exons encoding the coiled-coil domain. Experimental introduction of CARD11 coiled-coil domain mutants into lymphoma cell lines resulted in constitutive NF-kappaB activation and enhanced NF-kappaB activity upon antigen receptor stimulation. These results demonstrate that CARD11 is a bona fide oncogenein DLBCL, providing a genetic rationale for the development of pharmacological inhibitors of the CARD11 pathway for DLBCL therapy.

The Fifth Data Release of the Sloan Digital Sky Survey

Abstract: This paper describes the Fifth Data Release (DR5) of the Sloan Digital Sky Survey (SDSS). DR5 includes all survey quality data taken through 2005 June and represents the completion of the SDSS-I project (whose successor, SDSS-II, will continue through mid-2008). It includes five-band photometric data for 217 million objects selected over 8000 deg^2 and 1,048,960 spectra of galaxies, quasars, and stars selected from 5713 deg^2 of that imaging data. These numbers represent a roughly 20% increment over those of the Fourth Data Release; all the data from previous data releases are included in the present release. In addition to "standard" SDSS observations, DR5 includes repeat scans of the southern equatorial stripe, imaging scans across M31 and the core of the Perseus Cluster of galaxies, and the first spectroscopic data from SEGUE, a survey to explore the kinematics and chemical evolution of the Galaxy. The catalog database incorporates several new features, including photometric redshifts of galaxies, tables of matched objects in overlap regions of the imaging survey, and tools that allow precise computations of survey geometry for statistical investigations.

Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells

Abstract: High specific activity estradiol labeled with iodine-125 was used to detect approximately 200 saturable, high-affinity (dissociation constant approximately equal to 1.0 nM) nuclear binding sites in rat (ROS 17/2.8) and human (HOS TE85) clonal osteoblast-like osteosarcoma cells. Of the steroids tested, only testosterone exhibited significant cross-reactivity with estrogen binding. RNA blot analysis with a complementary DNA probe to the human estrogen receptor revealed putative receptor transcripts of 6 to 6.2 kilobases in both rat and human osteosarcoma cells. Type I procollagen and transforming growth factor-beta messenger RNA levels were enhanced in cultured human osteoblast-like cells treated with 1 nM estradiol. Thus, estrogen can act directly on osteoblasts by a receptor-mediated mechanism and thereby modulate the extracellular matrix and other proteins involved in the maintenance of skeletal mineralization and remodeling.

The Luminosity and Color Dependence of the Galaxy Correlation Function

Abstract: Westudytheluminosityandcolordependenceofthegalaxytwo-pointcorrelationfunctionintheSloanDigitalSky Survey, starting from a sample of � 200,000 galaxies over 2500 deg 2 . We concentrate our analysis on volume-limited subsamples of specified luminosity ranges, for which we measure the projected correlation function wp(rp), which is directly related to the real-space correlation function � (r). The amplitude of wp(rp) rises continuously with luminosity from Mr �� 17: 5t oMr �� 22:5, with the most rapid increase occurring above the characteristic luminosity L� (Mr �� 20:5). Over the scales 0:1 h � 1 Mpc � 22 can be approximated, imperfectly, by power-law three-dimensional correlation functions � (r) ¼ (r/r0) � � with � � 1:8 and r0(L� ) � 5:0 h � 1 Mpc. The brightest subsample, � 23 < Mr < � 22, has a significantly steeper � (r). When we divide samples by color, redder galaxies exhibit a higher amplitude and steeper correlation function at all luminosities. The correlation amplitude of blue galaxies increases continuously with luminosity, but the luminosity dependence for red galaxies is less regular, with bright red galaxies exhibiting the strongest clustering at large scales and faint red galaxies exhibiting the strongest clustering at small scales. We interpret these results using halo occupation distribution (HOD) models assuming concordance cosmological parameters. For most samples, an HOD model with two adjustable parameters fits the wp(rp) data better than a power law, explaining inflections at rp � 1 3 h � 1 Mpc as the transition between the one-halo and two-halo regimes of � (r). The implied minimum mass for a halo hosting a central galaxy more luminous than L grows steadily, with Mmin / L at low luminosities and a steeper dependence above L� . The mass at which a halo has, on average, one satellite galaxy brighter than L is M1 � 23Mmin(L), at all luminosities. These results imply a conditional luminosity function (at fixed halo mass) in which central galaxies lie far above a Schechter function extrapolation of the satellite population. The HOD model fits nicely explain the color dependence of wp(rp) and the cross correlation between red and blue galaxies. For galaxies with Mr < � 21, halos slightly above Mmin have blue central galaxies, while more massive halos have red central galaxies and predominantly red satellite populations. The fraction of blue central galaxies increases steadily with decreasing luminosity and host halo mass. The strong clustering offaint red galaxies follows from the fact that nearly all of them are satellite systems in high-mass halos. The HOD fitting results are in good qualitative agreement with the predictions of numerical and semianalytic models of galaxy formation. Subject headingg cosmology: observations — cosmology: theory — galaxies: distances and redshifts — galaxies: halos — galaxies: statistics — large-scale structure of universe

The Ectocarpus genome and the independent evolution of multicellularity in brown algae

Abstract: Brown algae (Phaeophyceae) are complex photosynthetic organisms with a very different evolutionary history to green plants, to which they are only distantly related. These seaweeds are the dominant species in rocky coastal ecosystems and they exhibit many interesting adaptations to these, often harsh, environments. Brown algae are also one of only a small number of eukaryotic lineages that have evolved complex multicellularity (Fig. 1). We report the 214 million base pair (Mbp) genome sequence of the filamentous seaweed Ectocarpus siliculosus (Dillwyn) Lyngbye, a model organism for brown algae closely related to the kelps (Fig. 1). Genome features such as the presence of an extended set of light-harvesting and pigment biosynthesis genes and new metabolic processes such as halide metabolism help explain the ability of this organism to cope with the highly variable tidal environment. The evolution of multicellularity in this lineage is correlated with the presence of a rich array of signal transduction genes. Of particular interest is the presence of a family of receptor kinases, as the independent evolution of related molecules has been linked with the emergence of multicellularity in both the animal and green plant lineages. The Ectocarpus genome sequence represents an important step towards developing this organism as a model species, providing the possibility to combine genomic and genetic approaches to explore these and other aspects of brown algal biology further