Showing papers by "University of Arizona published in 2007"
TL;DR: The past history, and likely future of this important topic has been/will remain more “evolution” than “big-bang”, and the current redefinition was flawed at inception owing to a fundamental problem with the troponin assays available at that time.
Abstract: Myocardial infarction is a major cause of death and disability worldwide. Coronary atherosclerosis is a chronic disease with stable and unstable periods. During unstable periods with activated inflammation in the vascular wall, patients may develop a myocardial infarction. Myocardial infarction may be a minor event in a lifelong chronic disease, it may even go undetected, but it may also be a major catastrophic event leading to sudden death or severe hemodynamic deterioration. A myocardial infarction may be the first manifestation of coronary artery disease, or it may occur, repeatedly, in patients with established disease. Information on myocardial infarction attack rates can provide useful data regarding the burden of coronary artery disease within and across populations, especially if standardized data are collected in a manner that demonstrates the distinction between incident and recurrent events. From the epidemiological point of view, the incidence of myocardial infarction in a population can be used as a proxy for the prevalence of coronary artery disease in that population. Furthermore, the term myocardial infarction has major psychological and legal implications for the individual and society. It is an indicator of one of the leading health problems in the world, and it is an outcome measure in clinical trials and observational studies. With these perspectives, myocardial infarction may be defined from a number of different clinical, electrocardiographic, biochemical, imaging, and pathological characteristics.
In the past, a general consensus existed for the clinical syndrome designated as myocardial infarction. In studies of disease prevalence, the World Health Organization (WHO) defined myocardial infarction from symptoms, ECG abnormalities, and enzymes. However, the development of more sensitive and specific serological biomarkers and precise imaging techniques allows detection of ever smaller amounts of myocardial necrosis. Accordingly, current clinical practice, health care delivery systems, as well as epidemiology and clinical trials all require a …
3,774 citations
TL;DR: In this paper, three basic models or forms of network governance are developed focusing on their distinct structural properties and the tensions inherent in each form are discussed, followed by the role that management may play in addressing these tensions.
Abstract: This article examines the governance of organizational networks and the impact of governance on network effectiveness. Three basic models, or forms, of network governance are developed focusing on their distinct structural properties. Propositions are formulated examining conditions for the effectiveness of each form. The tensions inherent in each form are then discussed, followed by the role that management may play in addressing these tensions. Finally, the evolution of governance is explored.
2,891 citations
University of California, Los Angeles1, United States Department of Energy2, University of Paris3, Duke University4, University of Massachusetts Medical School5, University of California, Berkeley6, Centre national de la recherche scientifique7, University of California, San Francisco8, Sun Yat-sen University9, University of Tennessee Health Science Center10, University of Minnesota11, Iowa State University12, Genetic Information Research Institute13, Salk Institute for Biological Studies14, Stanford University15, University of Liège16, University of Nebraska–Lincoln17, University of Cambridge18, Washington University in St. Louis19, University of Córdoba (Spain)20, Kyoto University21, Carnegie Institution for Science22, National Autonomous University of Mexico23, University of Münster24, École Normale Supérieure25, University of Melbourne26, University of Paris-Sud27, University of Mainz28, Scripps Research Institute29, Ohio State University30, University of Chicago31, University of Jena32, University of Arizona33, Louisiana State University34, University of New Brunswick35, University College London36, University of Potsdam37, Delaware Biotechnology Institute38, Boyce Thompson Institute for Plant Research39, Macquarie University40, Oklahoma State University Center for Health Sciences41, İzmir University of Economics42, Academy of Sciences of the Czech Republic43, Charles University in Prague44, St. Edward's University45, University of Puget Sound46, Hokkaido University47, Tsinghua University48, Washington State University49, Appalachian State University50, Marquette University51
TL;DR: Analyses of the Chlamydomonas genome advance the understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.
Abstract: Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the approximately 120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.
2,554 citations
TL;DR: These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution.
Abstract: Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
2,057 citations
TL;DR: This work focuses on paradigms that elicit N2 components with an anterior scalp distribution, namely, cognitive control, novelty, and sequential matching, and argues that the anterior N2 should be divided into separate control- and mismatch-related subcomponents.
Abstract: Recent years have seen an explosion of research on the N2 component of the event-related potential, a negative wave peaking between 200 and 350 ms after stimulus onset. This research has focused on the influence of ‘‘cognitive control,’’ a concept that covers strategic monitoring and control of motor responses. However, rich research traditions focus on attention and novelty or mismatch as determinants of N2 amplitude. We focus on paradigms that elicit N2 components with an anterior scalp distribution, namely, cognitive control, novelty, and sequential matching, and argue that the anterior N2 should be divided into separate control- and mismatch-related subcomponents. We also argue that the oddball N2 belongs in the family of attention-related N2 components that, in the visual modality, have a posterior scalp distribution. We focus on the visual modality for which components with frontocentral and more posterior scalp distributions can be readily distinguished.
1,985 citations
University of California, Santa Cruz1, University of Arizona2, Max Planck Society3, California Institute of Technology4, University of Nottingham5, Lawrence Berkeley National Laboratory6, Columbia University7, Harvard University8, University of California, Berkeley9, University of California, Los Angeles10
TL;DR: In this paper, the authors analyzed star formation as a function of stellar mass (M☉) and redshift z in the All-Wavelength Extended Groth Strip International Survey.
Abstract: We analyze star formation (SF) as a function of stellar mass (M☉) and redshift z in the All-Wavelength Extended Groth Strip International Survey. For 2905 field galaxies, complete to 10^10(10^10.8 )M at z < 0.7(1), with Keck
spectroscopic redshifts out to z = 1.1, we compile SF rates (SFRs) from emission lines, GALEX, and Spitzer MIPS 24 µm photometry, optical-NIR M* measurements, and HST morphologies. Galaxies with reliable signs of SF form a distinct “main sequence” (MS), with a limited range of SFRs at a given M* and z (1 σ ≾ ±0.3 dex), and log (SFR) approximately proportional to log M*. The range of log (SFR) remains constant to z > 1, while the MS as a whole moves to higher SFR as z increases. The range of the SFR along the MS constrains the amplitude of episodic variations of SF and the effect of mergers on the SFR. Typical galaxies spend ∼67%(95%) of their lifetime since z = 1 within a factor of ≾2(4) of their average SFR at a given M* and z. The dominant mode of the evolution of SF since z ∼ 1 is apparently a gradual decline of the average SFR in most individual galaxies, not a decreasing frequency of starburst episodes, or a decreasing factor by which SFRs are enhanced in starbursts. LIRGs at z ∼ 1 seem to mostly reflect the high SFR typical for massive galaxies at that epoch. The smooth MS may reflect that the same set of few physical processes governs SF prior to additional quenching processes. A gradual process like gas exhaustion may play a dominant role.
1,882 citations
TL;DR: In this article, the authors used the HST data to trace the history of cosmic expansion over the last 10 billion years, and found 21 new Type Ia supernovae (SNe Ia) with the Hubble Space Telescope (HST).
Abstract: We have discovered 21 new Type Ia supernovae (SNe Ia) with the Hubble Space Telescope (HST) and have used them to trace the history of cosmic expansion over the last 10 billion yr. These objects, which include 13 spectroscopicallyconfirmedSNeIaat z � 1,werediscoveredduring14epochsofreimagingoftheGOODSfieldsNorthand South over 2 yr with the Advanced Camera for Surveys on HST. Together with a recalibration of our previous HSTdiscovered SNe Ia, the full sample of 23 SNe Ia at z � 1 provides the highest redshift sample known. Combining these data with previous SN Ia data sets, we measured Hz ðÞ at discrete, uncorrelated epochs, reducing the uncertainty of Hz >1 ðÞ from 50% to under 20%, strengthening the evidence for a cosmic jerk—the transition from deceleration in the past to acceleration in thepresent. The uniqueleverage of theHSThigh-redshift SNe Ia provides thefirstmeaningful constraint on the dark energy equation-of-state parameter at z � 1. The result remains consistent with a cosmological constant [ wz ðÞ ¼� 1] and rules out rapidly evolving dark energy (dw/dz 31). The defining property of dark energy, its negative pressure, appears to be present at z > 1, in the epoch preceding acceleration, with � 98% confidenceinourprimaryfit.Moreover,thez > 1sample-averagedspectralenergydistributionisconsistentwiththat of thetypicalSNIaoverthelast10Gyr,indicatingthatanyspectralevolutionofthepropertiesof SNeIawithredshift is still below our detection threshold.
1,852 citations
California Institute of Technology1, University of Hawaii2, Max Planck Society3, ETH Zurich4, Harvard University5, Space Telescope Science Institute6, INAF7, University of Arizona8, University of Padua9, European Southern Observatory10, University of California, Los Angeles11, National Radio Astronomy Observatory12, Columbia University13, Tohoku University14, American Museum of Natural History15
TL;DR: The Cosmic Evolution Survey (COSMOS) as mentioned in this paper is designed to probe the correlated evolution of galaxies, star formation, active galactic nuclei (AGNs), and dark matter (DM) with large-scale structure (LSS) over the redshift range z > 0.5-6.
Abstract: The Cosmic Evolution Survey (COSMOS) is designed to probe the correlated evolution of galaxies, star formation, active galactic nuclei (AGNs), and dark matter (DM) with large-scale structure (LSS) over the redshift range z > 0.5-6. The survey includes multiwavelength imaging and spectroscopy from X-ray-to-radio wavelengths covering a 2 deg^2 area, including HST imaging. Given the very high sensitivity and resolution of these data sets, COSMOS also provides unprecedented samples of objects at high redshift with greatly reduced cosmic variance, compared to earlier surveys. Here we provide a brief overview of the survey strategy, the characteristics of the major COSMOS data sets, and a summary the science goals.
1,848 citations
TL;DR: In this article, the authors propose a service-dominant logic (S-D) for marketing and compare it with G-D to provide a framework for thinking more clearly about the concept of service and its role in exchange.
1,664 citations
TL;DR: The observation that irradiated combs from affected colonies can be repopulated with naive bees suggests that infection may contribute to colony collapse disorder (CCD).
Abstract: In colony collapse disorder (CCD), honey bee colonies inexplicably lose their workers. CCD has resulted in a loss of 50 to 90% of colonies in beekeeping operations across the United States. The observation that irradiated combs from affected colonies can be repopulated with naive bees suggests that infection may contribute to CCD. We used an unbiased metagenomic approach to survey microflora in CCD hives, normal hives, and imported royal jelly. Candidate pathogens were screened for significance of association with CCD by the examination of samples collected from several sites over a period of 3 years. One organism, Israeli acute paralysis virus of bees, was strongly correlated with CCD.
1,652 citations
TL;DR: The genomic changes that lead to amplification, overexpression, and coding sequence variation in the three major groups of genes encoding metabolic enzymes, i.e., cytochrome P450 monooxygenases (P450s), esterases, and glutathione-S-transferases (GSTs), are the focus of this review.
Abstract: Xenobiotic resistance in insects has evolved predominantly by increasing the metabolic capability of detoxificative systems and/or reducing xenobiotic target site sensitivity. In contrast to the limited range of nucleotide changes that lead to target site insensitivity, many molecular mechanisms lead to enhancements in xenobiotic metabolism. The genomic changes that lead to amplification, overexpression, and coding sequence variation in the three major groups of genes encoding metabolic enzymes, i.e., cytochrome P450 monooxygenases (P450s), esterases, and glutathione-S-transferases (GSTs), are the focus of this review. A substantial number of the adaptive genomic changes associated with insecticide resistance that have been characterized to date are transposon mediated. Several lines of evidence suggest that P450 genes involved in insecticide resistance, and perhaps insecticide detoxification genes in general, may share an evolutionary association with genes involved in allelochemical metabolism. Differences in the selective regime imposed by allelochemicals and insecticides may account for the relative importance of regulatory or structural mutations in conferring resistance.
TL;DR: The HiRISE camera as mentioned in this paper provides detailed images (0.25 to 1.3 m/pixel) covering ∼1% of the Martian surface during the 2-year Primary Science Phase (PSP) beginning November 2006.
Abstract: [1] The HiRISE camera features a 0.5 m diameter primary mirror, 12 m effective focal length, and a focal plane system that can acquire images containing up to 28 Gb (gigabits) of data in as little as 6 seconds. HiRISE will provide detailed images (0.25 to 1.3 m/pixel) covering ∼1% of the Martian surface during the 2-year Primary Science Phase (PSP) beginning November 2006. Most images will include color data covering 20% of the potential field of view. A top priority is to acquire ∼1000 stereo pairs and apply precision geometric corrections to enable topographic measurements to better than 25 cm vertical precision. We expect to return more than 12 Tb of HiRISE data during the 2-year PSP, and use pixel binning, conversion from 14 to 8 bit values, and a lossless compression system to increase coverage. HiRISE images are acquired via 14 CCD detectors, each with 2 output channels, and with multiple choices for pixel binning and number of Time Delay and Integration lines. HiRISE will support Mars exploration by locating and characterizing past, present, and future landing sites, unsuccessful landing sites, and past and potentially future rover traverses. We will investigate cratering, volcanism, tectonism, hydrology, sedimentary processes, stratigraphy, aeolian processes, mass wasting, landscape evolution, seasonal processes, climate change, spectrophotometry, glacial and periglacial processes, polar geology, and regolith properties. An Internet Web site (HiWeb) will enable anyone in the world to suggest HiRISE targets on Mars and to easily locate, view, and download HiRISE data products.
TL;DR: This paper reviewed and discussed the empirical literature on interorganizational networks at the network level of analysis, or what is sometimes referred to as "whole" networks, and offered a discussion concerning what future directions might be taken by researchers hoping to expand this important, but understudied, topic.
TL;DR: An emerging model of cytoplasmic mRNA function is suggested in which the rates of translation and degradation of mRNAs are influenced by a dynamic equilibrium between polysomes and the mRNPs seen in P bodies.
TL;DR: In this paper, a Bayesian method was proposed to account for measurement errors in linear regression of astronomical data. The method is based on deriving a likelihood function for the measured data, and focus on the case when the intrinsic distribution of the independent variables can be approximated using a mixture of Gaussian functions.
Abstract: I describe a Bayesian method to account for measurement errors in linear regression of astronomical data. The method allows for heteroscedastic and possibly correlated measurement errors and intrinsic scatter in the regression relationship. The method is based on deriving a likelihood function for the measured data, and I focus on the case when the intrinsic distribution of the independent variables can be approximated using a mixture of Gaussian functions. I generalize the method to incorporate multiple independent variables, nondetections, and selection effects (e.g., Malmquist bias). A Gibbs sampler is described for simulating random draws from the probability distribution of the parameters, given the observed data. I use simulation to compare the method with other common estimators. The simulations illustrate that the Gaussian mixture model outperforms other common estimators and can effectively give constraints on the regression parameters, even when the measurement errors dominate the observed scatter, source detection fraction is low, or the intrinsic distribution of the independent variables is not a mixture of Gaussian functions. I conclude by using this method to fit the X-ray spectral slope as a function of Eddington ratio using a sample of 39 z 0.8 radio-quiet quasars. I confirm the correlation seen by other authors between the radio-quiet quasar X-ray spectral slope and the Eddington ratio, where the X-ray spectral slope softens as the Eddington ratio increases. IDL routines are made available for performing the regression.
McGill University1, University of Groningen2, University of Oslo3, University of Michigan4, University of Auckland5, University of St Andrews6, University of Arizona7, University of California, Merced8, University of Alberta9, University of California, Santa Barbara10, Pontifical Catholic University of Chile11, University of Chile12, Michigan State University13, Arizona State University14
TL;DR: Theoretical, empirical and statistical developments in the study of Species abundance distributions are reviewed and it is optimistic that SADs can provide significant insights into basic and applied ecological science.
Abstract: Species abundance distributions (SADs) follow one of ecologys oldest and most universal laws – every community shows a hollow curve or hyperbolic shape on a histogram with many rare species and just a few common species. Here, we review theoretical, empirical and statistical developments in the study of SADs. Several key points emerge. (i) Literally dozens of models have been proposed to explain the hollow curve. Unfortunately, very few models are ever rejected, primarily because few theories make any predictions beyond the hollow-curve SAD itself. (ii) Interesting work has been performed both empirically and theoretically, which goes beyond the hollow-curve prediction to provide a rich variety of information about how SADs behave. These include the study of SADs along environmental gradients and theories that integrate SADs with other biodiversity patterns. Central to this body of work is an effort to move beyond treating the SAD in isolation and to integrate the SAD into its ecological context to enable making many predictions. (iii) Moving forward will entail understanding how sampling and scale affect SADs and developing statistical tools for describing and comparing SADs. We are optimistic that SADs can provide significant insights into basic and applied ecological science.
TL;DR: The experimental results for many standard test images show that prediction-error expansion doubles the maximum embedding capacity when compared to difference expansion, and there is a significant improvement in the quality of the watermarked image, especially at moderate embedding capacities.
Abstract: Reversible watermarking enables the embedding of useful information in a host signal without any loss of host information. Tian's difference-expansion technique is a high-capacity, reversible method for data embedding. However, the method suffers from undesirable distortion at low embedding capacities and lack of capacity control due to the need for embedding a location map. We propose a histogram shifting technique as an alternative to embedding the location map. The proposed technique improves the distortion performance at low embedding capacities and mitigates the capacity control problem. We also propose a reversible data-embedding technique called prediction-error expansion. This new technique better exploits the correlation inherent in the neighborhood of a pixel than the difference-expansion scheme. Prediction-error expansion and histogram shifting combine to form an effective method for data embedding. The experimental results for many standard test images show that prediction-error expansion doubles the maximum embedding capacity when compared to difference expansion. There is also a significant improvement in the quality of the watermarked image, especially at moderate embedding capacities
TL;DR: The data suggest that compared with a no-treatment control, brief training in mindfulness meditation or somatic relaxation reduces distress and improves positive mood states, and mindfulness meditation may be specific in its ability to reduce distractive and ruminative thoughts and behaviors.
Abstract: Background: Although mindfulness meditation interventions have recently shown benefits for reducing stress in various populations, little is known about their relative efficacy compared with relaxation interventions.Purpose: This randomized controlled trial examines the effects of a 1-month mindfulness meditation versus somatic relaxation training as compared to a control group in 83 students (M age=25; 16 men and 67 women) reporting distress.Method: Psychological distress, positive states of mind, distractive and ruminative thoughts and behaviors, and spiritual experience were measured, while controlling for social desirability.Results: Hierarchical linear modeling reveals that both meditation and relaxation groups experienced significant decreases in distress as well as increases in positive mood states over time, compared with the control group (p<.05 in all cases). There were no significant differences between meditation and relaxation on distress and positive mood states over time. Effect sizes for distress were large for both meditation and relaxation (Cohen’s d=1.36 and .91, respectively), whereas the meditation group showed a larger effect size for positive states of mind than relaxation (Cohen’s d=.71 and .25, respectively). The meditation group also demonstrated significant pre-post decreases in both distractive and ruminative thoughts/behaviors compared with the control group (p<.04 in all cases; Cohen’s d=.57 for rumination and .25 for distraction for the meditation group), with mediation models suggesting that mindfulness meditation’s effects on reducing distress were partially mediated by reducing rumination. No significant effects were found for spiritual experience.Conclusions: The data suggest that compared with a no-treatment control, brief training in mindfulness meditation or somatic relaxation reduces distress and improves positive mood states. However, mindfulness meditation may be specific in its ability to reduce distractive and ruminative thoughts and behaviors, and this ability may provide a unique mechanism by which mindfulness meditation reduces distress.
University of California, Santa Cruz1, University of Arizona2, University of Oxford3, Lawrence Berkeley National Laboratory4, Seoul National University5, University of California, Berkeley6, Princeton University7, University of Texas at Austin8, Max Planck Society9, University of Chicago10, National Taiwan University11, University of Florida12, University of Virginia13, Herzberg Institute of Astrophysics14, Johns Hopkins University15, New Mexico State University16
TL;DR: The DEEP2 and COMBO-17 surveys are compared to study luminosity functions of red and blue galaxies to z ~ 1, and the results imply that the number and total stellar mass of blue galaxies have been substantially constant since z = 1, whereas those of red galaxies (near L*) have been significantly rising as mentioned in this paper.
Abstract: The DEEP2 and COMBO-17 surveys are compared to study luminosity functions of red and blue galaxies to z ~ 1. The two surveys have different methods and sensitivities, but nevertheless results agree. After z ~ 1, M has dimmed by 1.2-1.3 mag for all colors of galaxies, * for blue galaxies has hardly changed, and * for red galaxies has at least doubled (our formal value is ~0.5 dex). Luminosity density jB has fallen by 0.6 dex for blue galaxies but has remained nearly constant for red galaxies. These results imply that the number and total stellar mass of blue galaxies have been substantially constant since z ~ 1, whereas those of red galaxies (near L*) have been significantly rising. To explain the new red galaxies, a ``mixed'' scenario is proposed in which star formation in blue cloud galaxies is quenched, causing them to migrate to the red sequence, where they merge further in a small number of stellar mergers. This mixed scenario matches the local boxy-disky transition for nearby ellipticals, as well as red sequence stellar population scaling laws such as the color-magnitude and Mg-? relations (which are explained as fossil relics from blue progenitors). Blue galaxies enter the red sequence via different quenching modes, each of which peaks at a different characteristic mass and time. The red sequence therefore likely builds up in different ways at different times and masses, and the concept of a single process that is ``downsizing'' (or upsizing) probably does not apply. Our claim in this paper of a rise in the number of red galaxies applies to galaxies near L*. Accurate counts of brighter galaxies on the steep part of the Schechter function require more accurate photometry than is currently available.
TL;DR: Noninvasively-determined central pulse pressure is more strongly related to vascular hypertrophy, extent of atherosclerosis, and cardiovascular events than is brachial blood pressure, and these findings support prospective examination of use of central blood pressure as a treatment target in future trials.
Abstract: Brachial blood pressure is predictive of cardiovascular outcome; however central pressure may better represent the load imposed on the coronary and cerebral arteries and thereby bear a stronger relationship to vascular damage and prognosis. Relations of brachial and central pressures to carotid artery hypertrophy (intimal-medial thickness and vascular mass), extent of atherosclerosis (plaque score), and incident cardiovascular events were examined in the Strong Heart Study. Central pressures were calculated using radial applanation tonometry. Among 3520 participants, central and brachial pulse pressures were more strongly related to vascular hypertrophy and extent of atherosclerosis than were systolic pressures. Central pulse pressure was more strongly related to all 3 arterial measures than was brachial pulse pressure (r0.364 versus 0.309 for plaque score; P0.001 for comparison of Spearman correlation coefficient; r0.293 versus 0.249 for intimal-medial thickness; P0.002; r0.320 versus 0.289 for vascular mass; P0.05). Among the 2403 participants free of clinical cardiovascular disease at baseline, 319 suffered fatal or nonfatal cardiovascular events during mean follow-up of 4.81.3 years. After adjustment for age, gender, current smoking, body mass index, cholesterol:HDL ratio, creatinine, fibrinogen, diabetes, and heart rate, central pulse pressure predicted cardiovascular events more strongly than brachial pulse pressure (hazards ratio1.15 per 10 mm Hg, 2 13.4, P0.001 versus hazards ratio1.10, 2 6.9, P0.008). In conclusion, noninvasively-determined central pulse pressure is more strongly related to vascular hypertrophy, extent of atherosclerosis, and cardiovascular events than is brachial blood pressure. These findings support prospective examination of use of central blood pressure as a treatment target in future trials. (Hypertension. 2007;50:197-203.)
Princeton University1, University of Wyoming2, Imperial College London3, University of Arizona4, California Institute of Technology5, University of Cambridge6, University of Missouri7, Max Planck Society8, Space Telescope Science Institute9, New York University10, Yale University11, Ames Research Center12
TL;DR: Physical dust models for 65 galaxies in SINGS that are strongly detected in the four IRAC bands and three MIPS bands were presented for each galaxy as discussed by the authors, estimating the total dust mass, the fraction of the dust mass contributed by PAHs, and the intensity of the starlight heating the dust grains.
Abstract: Physical dust models are presented for 65 galaxies in SINGS that are strongly detected in the four IRAC bands and three MIPS bands. For each galaxy we estimate (1) the total dust mass, (2) the fraction of the dust mass contributed by PAHs, and (3) the intensity of the starlight heating the dust grains. We find that spiral galaxies have dust properties resembling the dust in the local region of the Milky Way, with similar dust-to-gas ratio and similar PAH abundance. The observed SEDs, including galaxies with SCUBA photometry, can be reproduced by dust models that do not require "cold" (T ≾ 10 K) dust. The dust-to-gas ratio is observed to be dependent on metallicity. In the interstellar media of galaxies with A_O ≡ 12 + log_(10)(O/H) > 8.1, grains contain a substantial fraction of interstellar Mg, Si, and Fe. Galaxies with A_O 8.1 have a median q_(PAH) = 3.55%. The derived dust masses favor a value X_(CO) ≈ 4 × 10^(20) cm^(-2) (K km s^(-1))^(-1) for the CO-to-H_2 conversion factor. Except for some starbursting systems (Mrk 33, Tol 89, NGC 3049), dust in the diffuse ISM dominates the IR power.
TL;DR: Transcriptome analysis of Arabidopsis has revealed the involvement of factors other than classical heat stress responsive genes in thermotolerance, suggesting both plant hormones and reactive oxygen species also contribute to heat stress signaling.
TL;DR: This work used a highly resolved empirical network of interactions between 1420 pollinator and 429 plant species to simulate consequences of the phenological shifts that can be expected with a doubling of atmospheric CO(2), causing as much as half of the ancestral activity period of the animals to fall at times when no food plants were available.
Abstract: Anthropogenic climate change is widely expected to drive species extinct by hampering individual survival and reproduction, by reducing the amount and accessibility of suitable habitat, or by eliminating other organisms that are essential to the species in question. Less well appreciated is the likelihood that climate change will directly disrupt or eliminate mutually beneficial (mutualistic) ecological interactions between species even before extinctions occur. We explored the potential disruption of a ubiquitous mutualistic interaction of terrestrial habitats, that between plants and their animal pollinators, via climate change. We used a highly resolved empirical network of interactions between 1420 pollinator and 429 plant species to simulate consequences of the phenological shifts that can be expected with a doubling of atmospheric CO2. Depending on model assumptions, phenological shifts reduced the floral resources available to 1750% of all pollinator species, causing as much as half of the ancestral activity period of the animals to fall at times when no food plants were available. Reduced overlap between plants and pollinators also decreased diet breadth of the pollinators. The predicted result of these disruptions is the extinction of pollinators, plants and their crucial interactions.
University of Massachusetts Amherst1, Space Telescope Science Institute2, University of Cambridge3, University of Arizona4, Princeton University5, University of Hawaii at Manoa6, New York University7, University of Wyoming8, California Institute of Technology9, Ames Research Center10, Imperial College London11, University of Missouri12, Yale University13, Max Planck Society14, Bucknell University15
TL;DR: In this paper, the authors analyzed Spitzer 8 and 24 μm data of star-forming regions in a sample of 33 nearby galaxies with available HST NICMOS images in the Paα (1.8756 μm) emission line.
Abstract: With the goal of investigating the degree to which the MIR emission traces the SFR, we analyze Spitzer 8 and 24 μm data of star-forming regions in a sample of 33 nearby galaxies with available HST NICMOS images in the Paα (1.8756 μm) emission line. The galaxies are drawn from the SINGS sample and cover a range of morphologies and a factor ~10 in oxygen abundance. Published data on local low-metallicity starburst galaxies and LIRGs are also included in the analysis. Both the stellar continuum-subtracted 8 μm emission and the 24 μm emission correlate with the extinction-corrected Paα line emission, although neither relationship is linear. Simple models of stellar populations and dust extinction and emission are able to reproduce the observed nonlinear trend of the 24 μm emission versus number of ionizing photons, including the modest deficiency of 24 μm emission in the low-metallicity regions, which results from a combination of decreasing dust opacity and dust temperature at low luminosities. Conversely, the trend of the 8 μm emission as a function of the number of ionizing photons is not well reproduced by the same models. The 8 μm emission is contributed, in larger measure than the 24 μm emission, by dust heated by nonionizing stellar populations, in addition to the ionizing ones, in agreement with previous findings. Two SFR calibrations, one using the 24 μm emission and the other using a combination of the 24 μm and Hα luminosities (Kennicutt and coworkers), are presented. No calibration is presented for the 8 μm emission because of its significant dependence on both metallicity and environment. The calibrations presented here should be directly applicable to systems dominated by ongoing star formation.
ETH Zurich1, Centre national de la recherche scientifique2, University of Padua3, INAF4, Max Planck Society5, Brera Astronomical Observatory6, California Institute of Technology7, Paris Diderot University8, Institut d'Astrophysique de Paris9, University of Hawaii10, Tohoku University11, University of Nottingham12, University of Arizona13, Space Telescope Science Institute14, University of Bologna15, European Southern Observatory16, University of Edinburgh17, Columbia University18, Durham University19
TL;DR: The zCOSMOS-bright survey as discussed by the authors is a large-redshift survey that is being undertaken in the CosMOS field using 600 hr of observation with the VIMOS spectrograph on the 8 m VLT.
Abstract: zCOSMOS is a large-redshift survey that is being undertaken in the COSMOS field using 600 hr of observation
with the VIMOS spectrograph on the 8 m VLT. The survey is designed to characterize the environments of COSMOS
galaxies from the 100 kpc scales of galaxy groups up to the 100 Mpc scale of the cosmic web and to produce diagnostic
information on galaxies and active galactic nuclei. The zCOSMOS survey consists of two parts: (1) zCOSMOSbright,
a magnitude-limited I-band I_(AB) < 22.5 sample of about 20,000 galaxies with 0.1 < z < 1.2 covering the whole
1.7 deg^2 COSMOS ACS field, for which the survey parameters at z ~ 0.7 are designed to be directly comparable to
those of the 2dFGRS at z ~ 0.1; and (2) zCOSMOS-deep, a survey of approximately 10,000 galaxies selected through
color-selection criteria to have 1.4 < z < 3.0, within the central 1 deg^2. This paper describes the survey design and the
construction of the target catalogs and briefly outlines the observational program and the data pipeline. In the first
observing season, spectra of 1303 zCOSMOS-bright targets and 977 zCOSMOS-deep targets have been obtained.
These are briefly analyzed to demonstrate the characteristics that may be expected from zCOSMOS, and particularly
zCOSMOS-bright, when it is finally completed between 2008 and 2009. The power of combining spectroscopic and
photometric redshifts is demonstrated, especially in correctly identifying the emission line in single-line spectra and in
determining which of the less reliable spectroscopic redshifts are correct and which are incorrect. These techniques
bring the overall success rate in the zCOSMOS-bright so far to almost 90% and to above 97% in the 0.5 < z < 0.8
redshift range. Our zCOSMOS-deep spectra demonstrate the power of our selection techniques to isolate high-redshift
galaxies at 1.4 < z < 3.0 and of VIMOS to measure their redshifts using ultraviolet absorption lines.
University of Arizona1, Princeton University2, University of Wyoming3, University of Cambridge4, California Institute of Technology5, Max Planck Society6, Imperial College London7, Space Telescope Science Institute8, Ames Research Center9, University of Missouri10, Arizona State University11, Yale University12
TL;DR: In this article, a sample of low-resolution 5-38 μm Spitzer IRS spectra of the inner few square kiloparsecs of 59 nearby galaxies spanning a large range of star formation properties was used to explore the behavior of PAH emission and the prevalence of silicate dust extinction.
Abstract: We present a sample of low-resolution 5-38 μm Spitzer IRS spectra of the inner few square kiloparsecs of 59 nearby galaxies spanning a large range of star formation properties. A robust method for decomposing mid-infrared galaxy spectra is described and used to explore the behavior of PAH emission and the prevalence of silicate dust extinction. Evidence for silicate extinction is found in ~1/8 of the sample, at strengths that indicate that most normal galaxies undergo A_V ≲ 3 mag averaged over their centers. The contribution of PAH emission to the total infrared power is found to peak near 10% and extend up to ~20% and is suppressed at metallicities Z ≲ Z_☉/4, as well as in low-luminosity AGN environments. Strong interband PAH feature strength variations (2-5 times) are observed, with the presence of a weak AGN and, to a lesser degree, increasing metallicity shifting power to the longer wavelength bands. A peculiar PAH emission spectrum with markedly diminished 5-8 μm features arises among the sample solely in systems with relatively hard radiation fields harboring low-luminosity AGNs. The AGNs may modify the emitting grain distribution and provide the direct excitation source of the unusual PAH emission, which cautions against using absolute PAH strength to estimate star formation rates in systems harboring active nuclei. Alternatively, the low star formation intensity often associated with weak AGNs may affect the spectrum. The effect of variations in the mid-infrared spectrum on broadband infrared surveys is modeled and points to more than a factor of 2 uncertainty in results that assume a fixed PAH emission spectrum, for redshifts z = 0-2.5.
TL;DR: It is shown that DBS selectively interferes with the normal ability to slow down when faced with decision conflict, which implicate independent mechanisms leading to impulsivity in treated Parkinson's patients and were predicted by a single neurocomputational model of the basal ganglia.
Abstract: Deep brain stimulation (DBS) of the subthalamic nucleus markedly improves the motor symptoms of Parkinson's disease, but causes cognitive side effects such as impulsivity. We showed that DBS selectively interferes with the normal ability to slow down when faced with decision conflict. While on DBS, patients actually sped up their decisions under high-conflict conditions. This form of impulsivity was not affected by dopaminergic medication status. Instead, medication impaired patients' ability to learn from negative decision outcomes. These findings implicate independent mechanisms leading to impulsivity in treated Parkinson's patients and were predicted by a single neurocomputational model of the basal ganglia.
TL;DR: For hydrogen-helium-rich planets, the authors in this article couple planetary evolution to stellar irradiation over a wide range of orbital separations (0.02-10 AU) through a nongray radiative-convective equilibrium atmosphere model.
Abstract: Toaidinthephysicalinterpretationofplanetaryradii constrainedthroughobservationsoftransitingplanets,oreventuallydirectdetections,wecomputemodelradiiofpurehydrogen-helium,water,rock,andironplanets,alongwithvarious mixtures. Masses ranging from 0.01 Earth masses to 10 Jupiter masses at orbital distances of 0.02–10 AU are considered. For hydrogen-helium rich planets, our models are the first to couple planetary evolution to stellar irradiation over a wide range of orbital separations (0.02–10 AU) through a nongray radiative-convective equilibrium atmosphere model. Stellar irradiation retards the contraction of giant planets, but its effect is not a simple function of theirradiationlevel:aplanetat1AUcontractsasslowlyasaplanetat0.1AU.WeconfirmtheassertionofGuillotthat very old giant planets under modest stellar irradiation (like that received by Jupiter and Saturn) develop isothermal atmospheric radiative zones once the planet’s intrinsic flux drops to a small fraction of the incident flux. For hydrogenhelium planets, we consider cores up to 90% of the total planet mass, comparable to those of Uranus and Neptune. If ‘‘hot Neptunes’’ have maintained their original masses and are not remnants of more massive planets, radii of � 0.30– 0.45RJ areexpected.Waterplanetsare � 40%–50%largerthanrockyplanets,independentofmass.Finally,weprovide tables of planetary radii at various ages and compositions, and for ice-rock-iron planets we fit our results to analytic functions, which will allow for quick composition estimates, given masses and radii, or mass estimates, given only planetary radii. These results will assist in the interpretation of observations for both the current transiting planet surveys as well as upcoming space missions, including COROT and Kepler.
TL;DR: The Sexual Experiences Survey (SES) as mentioned in this paper assesses victimization and perpetration of unwanted sexual experiences (e.g., Koss, Gidycz, & Wisniewski, 1987).
Abstract: The Sexual Experiences Survey (SES) assesses victimization and perpetration of unwanted sexual experiences (e.g., Koss, Gidycz, & Wisniewski, 1987). Revised versions of the SES that resulted from the work of the SES Collaboration are now available. This article reviews weaknesses of the SES that were identified, strengths that were preserved, and methodological considerations in the measurement of unwanted sexual experiences that informed the revisions. The primary changes include: more behavioral specificity; conversion to gender neutrality; full crossing of unwanted acts and coercive tactics; and revised and updated wording for assessing consent, alcohol-related incidents, unwanted acts, and coercive tactics. For illustration, the full text of the revised victimization version and its scoring rules are provided. The article concludes with suggestions for future research. These suggestions aim to involve researchers in a coordinated agenda to develop data that clarify methodological questions and contribute to continued improvement in assessing sexual victimization and perpetration.
TL;DR: In this article, the authors demonstrate the management of organizational justice with some suggestions for building fairness into widely used managerial activities, such as hiring, performance appraisal, reward systems, conflict management, and downsizing.
Abstract: Executive Overview Organizational justice has the potential to create powerful benefits for organizations and employees alike. These include greater trust and commitment, improved job performance, more helpful citizenship behaviors, improved customer satisfaction, and diminished conflict. We demonstrate the management of organizational justice with some suggestions for building fairness into widely used managerial activities. These include hiring, performance appraisal, reward systems, conflict management, and downsizing.