University of Bath

About: University of Bath is a education organization based out in Bath, Bath and North East Somerset, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 15830 authors who have published 39608 publications receiving 1358769 citations. The organization is also known as: Bath University.

Conductive metal–organic frameworks and networks: fact or fantasy?

Abstract: Electrical conduction is well understood in materials formed from inorganic or organic building blocks, but their combination to produce conductive hybrid frameworks and networks is an emerging and rapidly developing field of research. Self-assembling organic–inorganic compounds offer immense potential for functionalising material properties for a wide scope of applications including solar cells, light emitters, gas sensors and bipolar transparent conductors. The flexibility of combining two distinct material classes into a single solid-state system provides an almost infinite number of chemical and structural possibilities; however, there is currently no systematic approach established for designing new compositions and configurations with targeted electronic or optical properties. We review the current status in the field, in particular, the range of hybrid systems reported to date and the important role of materials modelling in the field. From theoretical arguments, the Mott insulator-to-metal transition should be possible in semiconducting metal–organic frameworks, but has yet to be observed. The question remains as to whether electro-active hybrid materials will evolve from chemical curiosities towards practical applications in the near term.

Role of Adaptor Complex AP-3 in Targeting Wild- Type and Mutated CD63 to Lysosomes

Abstract: CD63 is a lysosomal membrane protein that belongs to the tetraspanin family. Its carboxyterminal cytoplasmic tail sequence contains the lysosomal targeting motif GYEVM. Strong, tyrosine-dependent interaction of the wild-type carboxyterminal tail of CD63 with the AP-3 adaptor subunit μ3 was observed using a yeast two-hybrid system. The strength of interaction of mutated tail sequences with μ3 correlated with the degree of lysosomal localization of similarly mutated human CD63 molecules in stably transfected normal rat kidney cells. Mutated CD63 containing the cytosolic tail sequence GYEVI, which interacted strongly with μ3 but not at all with μ2 in the yeast two-hybrid system, localized to lysosomes in transfected normal rat kidney and NIH-3T3 cells. In contrast, it localized to the cell surface in transfected cells of pearl and mocha mice, which have genetic defects in genes encoding subunits of AP-3, but to lysosomes in functionally rescued mocha cells expressing the δ subunit of AP-3. Thus, AP-3 is absolutely required for the delivery of this mutated CD63 to lysosomes. Using this AP-3–dependent mutant of CD63, we have shown that AP-3 functions in membrane traffic from the trans-Golgi network to lysosomes via an intracellular route that appears to bypass early endosomes.

Repositioning Higher Education as a global commodity: opportunities and challenges for future sociology of education work

Abstract: (2003). Repositioning Higher Education as a Global Commodity: Opportunities and challenges for future sociology of education work. British Journal of Sociology of Education: Vol. 24, No. 2, pp. 249-259.

Direct method for TDS stability analysis

Abstract: A direct approach to the analysis of systems with single, or commensurate delays is presented, and compared with other recently proposed methods. The finite polynomials arising in this direct method are shown to have useful sensitivity properties. Remarks are given concerning systems stable independent of delay.