Institution
University of Bath
Education•Bath, Bath and North East Somerset, United Kingdom•
About: University of Bath is a education organization based out in Bath, Bath and North East Somerset, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 15830 authors who have published 39608 publications receiving 1358769 citations. The organization is also known as: Bath University.
Papers published on a yearly basis
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TL;DR: Both experiments demonstrate that chronic pain patients suffering high intensity pain show significantly impaired performance on an attentionally demanding task when compared to low pain patients and normal controls and re-addresses the literature on coping with pain in terms of cognitive theories of attention.
311 citations
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TL;DR: A review of the xenobiotic resistance literature shows that empirical evidence for this hypothesis is scarce, and it is postulate that such fitness costs can only be fully interpreted in the light of the molecular mutations that might underlie them.
Abstract: The nature and cost of single genes of major effect is one of the longest running controversies in biology. Resistance, whether to xenobiotics or to parasites, is often paraded as an obvious example of a single gene effect that must carry an associated fitness 'cost'. However, a review of the xenobiotic resistance literature shows that empirical evidence for this hypothesis is, in fact, scarce. We postulate that such fitness costs can only be fully interpreted in the light of the molecular mutations that might underlie them. We also derive a theoretical framework both to encompass our current understanding of xenobiotic resistance and to begin to dissect the probable cost of parasite resistance.
311 citations
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TL;DR: The fabrication and characterization of a new type of hollow-core photonic crystal fiber based on large-pitch kagome lattice lattice cladding is reported, with broad optical transmission bands covering the visible and near-IR parts of the spectrum with relatively low loss and low chromatic dispersion.
Abstract: We report the fabrication and characterization of a new type of hollow-core photonic crystal fiber based on large-pitch (∼12μm) kagome lattice cladding. The optical characteristics of the 19-cell, 7-cell, and single-cell core defect fibers include broad optical transmission bands covering the visible and near-IR parts of the spectrum with relatively low loss and low chromatic dispersion, no detectable surface modes and high confinement of light in the core. Various applications of such a novel fiber are also discussed, including gas sensing, quantum optics, and high harmonic generation.
310 citations
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TL;DR: Bile acids activate TGR5 on sensory nerves, stimulating the release of neuropeptides in the spinal cord that transmit itch and analgesia, which could contribute to pruritus and painless jaundice that occur during cholestatic liver diseases.
Abstract: Patients with cholestatic disease exhibit pruritus and analgesia, but the mechanisms underlying these symptoms are unknown. We report that bile acids, which are elevated in the circulation and tissues during cholestasis, cause itch and analgesia by activating the GPCR TGR5. TGR5 was detected in peptidergic neurons of mouse dorsal root ganglia and spinal cord that transmit itch and pain, and in dermal macrophages that contain opioids. Bile acids and a TGR5-selective agonist induced hyperexcitability of dorsal root ganglia neurons and stimulated the release of the itch and analgesia transmitters gastrin-releasing peptide and leucine-enkephalin. Intradermal injection of bile acids and a TGR5-selective agonist stimulated scratching behavior by gastrin-releasing peptide- and opioid-dependent mechanisms in mice. Scratching was attenuated in Tgr5-KO mice but exacerbated in Tgr5-Tg mice (overexpressing mouse TGR5), which exhibited spontaneous pruritus. Intraplantar and intrathecal injection of bile acids caused analgesia to mechanical stimulation of the paw by an opioid-dependent mechanism. Both peripheral and central mechanisms of analgesia were absent from Tgr5-KO mice. Thus, bile acids activate TGR5 on sensory nerves, stimulating the release of neuropeptides in the spinal cord that transmit itch and analgesia. These mechanisms could contribute to pruritus and painless jaundice that occur during cholestatic liver diseases.
309 citations
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TL;DR: This paper explored the relationship between religious denomination and individual attitudes to corporate social responsibility within the context of a large sample of over 17,000 individuals drawn from 20 countries and found that religious individuals tend to hold broader conceptions of the social responsibilities of businesses than non-religious individuals.
Abstract: This paper explores the relationship between religious denomination and individual attitudes to corporate social responsibility within the context of a large sample of over 17,000 individuals drawn from 20 countries. We address two general questions: do members of religious denominations have different attitudes concerning CSR than people of no denomination? And: do members of different religions have different attitudes to CSR that conform to general priors about the teachings of different religions? Our evidence suggests that, broadly, religious individuals do tend to hold broader conceptions of the social responsibilities of businesses than non-religious individuals. However, we show that this neither true for all religious groups, nor for all areas of corporate social responsibility.
309 citations
Authors
Showing all 16056 results
Name | H-index | Papers | Citations |
---|---|---|---|
Michael Grätzel | 248 | 1423 | 303599 |
Brenda W.J.H. Penninx | 170 | 1139 | 119082 |
Amartya Sen | 149 | 689 | 141907 |
Gilbert Laporte | 128 | 730 | 62608 |
Andre K. Geim | 125 | 445 | 206833 |
Matthew Jones | 125 | 1161 | 96909 |
Benoît Roux | 120 | 493 | 62215 |
Stephen Mann | 120 | 669 | 55008 |
Bruno S. Frey | 119 | 900 | 65368 |
Raymond A. Dwek | 118 | 603 | 52259 |
David Cutts | 114 | 778 | 64215 |
John Campbell | 107 | 1150 | 56067 |
David Chandler | 107 | 424 | 52396 |
Peter H.R. Green | 106 | 843 | 60113 |
Huajian Gao | 105 | 667 | 46748 |