Institution
University of California, Davis
Education•Davis, California, United States•
About: University of California, Davis is a education organization based out in Davis, California, United States. It is known for research contribution in the topics: Population & Gene. The organization has 78770 authors who have published 180033 publications receiving 8064158 citations. The organization is also known as: UC Davis & UCD.
Topics: Population, Gene, Poison control, Context (language use), Medicine
Papers published on a yearly basis
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Brigham and Women's Hospital1, Harvard University2, Massachusetts Institute of Technology3, National Institutes of Health4, University of Toronto5, University of Manchester6, Celera Corporation7, Leiden University8, Karolinska Institutet9, University of Texas at Austin10, Radboud University Nijmegen Medical Centre11, University of California, San Francisco12, VU University Amsterdam13, University of Leeds14, University of Oxford15, University of Aberdeen16, The Feinstein Institute for Medical Research17, Karolinska University Hospital18, University of Groningen19, University of California, Davis20, King's College21, University of Amsterdam22, University of Sheffield23, Hoffmann-La Roche24, University Health Network25, North Shore-LIJ Health System26, Broad Institute27
TL;DR: Seven new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 × 10−8) in an analysis of all 41,282 samples, and an additional 11 SNPs replicated at P < 0.05, suggesting that most represent genuine rhearatoid arthritisrisk alleles.
Abstract: To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid arthritis (cases) and 20,169 controls of European descent, followed by replication in an independent set of 6,768 rheumatoid arthritis cases and 8,806 controls. Of 34 SNPs selected for replication, 7 new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 x 10(-8)) in an analysis of all 41,282 samples. The associated SNPs are near genes of known immune function, including IL6ST, SPRED2, RBPJ, CCR6, IRF5 and PXK. We also refined associations at two established rheumatoid arthritis risk loci (IL2RA and CCL21) and confirmed the association at AFF3. These new associations bring the total number of confirmed rheumatoid arthritis risk loci to 31 among individuals of European ancestry. An additional 11 SNPs replicated at P < 0.05, many of which are validated autoimmune risk alleles, suggesting that most represent genuine rheumatoid arthritis risk alleles.
1,277 citations
University of California, Berkeley1, Bryn Mawr College2, Food and Agriculture Organization3, San Francisco State University4, University of Rochester5, York University6, University of Reading7, University of Virginia8, University of Bayreuth9, University of Montana10, University of California, Davis11, University of Texas at Austin12, University of Göttingen13, University of California, Santa Barbara14
TL;DR: A conceptual model for exploring how one mobile-agent-based ecosystem service (MABES), pollination, is affected by land-use change, and then generalize the model to other MABES is developed.
Abstract: Many ecosystem services are delivered by organisms that depend on habitats that are segregated spatially or temporally from the location where services are provided. Management of mobile organisms contributing to ecosystem services requires consideration not only of the local scale where services are delivered, but also the distribution of resources at the landscape scale, and the foraging ranges and dispersal movements of the mobile agents. We develop a conceptual model for exploring how one such mobile-agent-based ecosystem service (MABES), pollination, is affected by land-use change, and then generalize the model to other MABES. The model includes interactions and feedbacks among policies affecting land use, market forces and the biology of the organisms involved. Animal-mediated pollination contributes to the production of goods of value to humans such as crops; it also bolsters reproduction of wild plants on which other services or service-providing organisms depend. About onethird of crop production depends on animal pollinators, while 60–90% of plant species require an animal pollinator. The sensitivity of mobile organisms to ecological factors that operate across spatial scales makes the services provided by a given community of mobile agents highly contextual. Services vary, depending on the spatial and temporal distribution of resources surrounding the site, and on biotic interactions occurring locally, such as competition among pollinators for resources, and among plants for pollinators. The value of the resulting goods or services may feed back via market-based forces to influence land-use policies, which in turn influence land management practices that alter local habitat conditions and landscape structure. Developing conceptual
1,277 citations
TL;DR: For a VAR with drifting coefficients and stochastic volatilities, the authors present posterior densities for several objects that are pertinent for designing and evaluating monetary policy, including measures of inflation persistence, the natural rate of unemployment, a core rate of inflation, and ‘activism coefficients' for monetary policy rules.
1,276 citations
TL;DR: Evidence is presented here showing that trehalose has a remarkably high glass-transition temperature (Tg), which makes this sugar useful in stabilization of biomolecules of use in human welfare and may explain the stability and longevity of anhydrobiotes that contain it.
Abstract: Numerous organisms are capable of surviving more or less complete dehydration. A common feature in their biochemistry is that they accumulate large amounts of disaccharides, the most common of which are sucrose and trehalose. Over the past 20 years, we have provided evidence that these sugars stabilize membranes and proteins in the dry state, most likely by hydrogen bonding to polar residues in the dry macromolecular assemblages. This direct interaction results in maintenance of dry proteins and membranes in a physical state similar to that seen in the presence of excess water. An alternative viewpoint has been proposed, based on the fact that both sucrose and trehalose form glasses in the dry state. It has been suggested that glass formation (vitrification) is in itself sufficient to stabilize dry biomaterials. In this review we present evidence that, although vitrification is indeed required, it is not in itself sufficient. Instead, both direct interaction and vitrification are required. Special properties have often been claimed for trehalose in this regard. In fact, trehalose has been shown by many workers to be remarkably (and sometimes uniquely) effective in stabilizing dry or frozen biomolecules, cells, and tissues. Others have not observed any such special properties. We review evidence here showing that trehalose has a remarkably high glass-transition temperature (Tg). It is not anomalous in this regard because it lies at the end of a continuum of sugars with increasing Tg. However, it is unusual in that addition of small amounts of water does not depress Tg, as in other sugars. Instead, a dihydrate crystal of trehalose forms, thereby shielding the remaining glassy trehalose from effects of the added water. Thus under less than ideal conditions such as high humidity and temperature, trehalose does indeed have special properties, which may explain the stability and longevity of anhydrobiotes that contain it. Further, it makes this sugar useful in stabilization of biomolecules of use in human welfare.
1,276 citations
Book•
26 Nov 1991TL;DR: In this paper, the authors present a comparison of various types of metals, chemical properties, and their application in low-dimensional carons and two-dimensional nanomaterials.
Abstract: TRADITIONAL MATERIALS Metals Physical Properties Chemical Properties Ceramics Physical Properties Chemical Properties Glasses Physical Properties Chemical Properties Polymers Physical Properties Chemical Properties Composites Physical Properties Chemical Properties Semiconductors Physical Properties Chemical Properties ADVANCED MATERIALS Low-Dimensional Carbons and Two-Dimensional Nanomaterials Physical Properties Chemical Properties MAX Phases Physical Properties Chemical Properties References Amorphous Metals Physical Properties References
1,275 citations
Authors
Showing all 79538 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Eric S. Lander | 301 | 826 | 525976 |
| Ronald C. Kessler | 274 | 1332 | 328983 |
| George M. Whitesides | 240 | 1739 | 269833 |
| Ronald M. Evans | 199 | 708 | 166722 |
| Virginia M.-Y. Lee | 194 | 993 | 148820 |
| Scott M. Grundy | 187 | 841 | 231821 |
| Julie E. Buring | 186 | 950 | 132967 |
| Patrick O. Brown | 183 | 755 | 200985 |
| Anil K. Jain | 183 | 1016 | 192151 |
| John C. Morris | 183 | 1441 | 168413 |
| Douglas R. Green | 182 | 661 | 145944 |
| John R. Yates | 177 | 1036 | 129029 |
| Barry Halliwell | 173 | 662 | 159518 |
| Roderick T. Bronson | 169 | 679 | 107702 |
| Hongfang Liu | 166 | 2356 | 156290 |