University of Cologne

About: University of Cologne is a education organization based out in Cologne, Germany. It is known for research contribution in the topics: Population & Gene. The organization has 32050 authors who have published 66350 publications receiving 2210092 citations. The organization is also known as: Universität zu Köln & Universitatis Coloniensis.

Cosmogenic nuclides : principles, concepts and applications in the earth surface sciences

Abstract: This is the first book to provide a comprehensive and state-of-the-art introduction to the novel and fast-evolving topic of in-situ produced cosmogenic nuclides. It presents an accessible introduction to the theoretical foundations, with explanations of relevant concepts starting at a basic level and building in sophistication. It incorporates, and draws on, methodological discussions and advances achieved within the international CRONUS (Cosmic-Ray Produced Nuclide Systematics) networks. Practical aspects such as sampling, analytical methods and data-interpretation are discussed in detail and an essential sampling checklist is provided. The full range of cosmogenic isotopes is covered and a wide spectrum of in-situ applications are described and illustrated with specific and generic examples of exposure dating, burial dating, erosion and uplift rates, and process model verification. Graduate students and experienced practitioners will find this book a vital source of information on the background concepts and practical applications in geomorphology, geography, soil-science, and geology.

A shift of the NAO and increasing storm track activity over Europe due to anthropogenic greenhouse gas forcing

Abstract: In accordance with a number of other general circulation model experiments, the coupled atmosphere-ocean-GCM ECHAM4+OPYC3 simulates increasing upper air storm track activity over the east Atlantic and Western Europe with rising greenhouse gas forcing. This paper addresses the question to what extent this change is attributable to the variable north Atlantic Oscillation (NAO), which is closely related to the intensity of the Atlantic storm track’s extension into Europe. The NAO index, which is based on sea level pressure fluctuations over the north Atlantic in the 300-y control run of this model, only shows a moderate increase within the 240-y scenario run, so that its long-term trend does not exceed the variability of the control climate before the end of the simulation. In contrast, the steadily growing storm track activity over northwestern Europe already surpasses the standard deviation defined from the control run after about 160 y. This effect is associated with a change of the NAO pattern. A determination of the centres of action for subsequent 10-y periods based on empirical orthogonal functions shows a systematic northeastward shift of the NAO’s northern variability centre from a position close to the east coast of Greenland, where it is also located in the control run, to the Norwegian Sea.

Spontaneous Skin Ulceration and Defective T Cell Function in CD18 Null Mice

Abstract: A null mutation was prepared in the mouse for CD18, the β2 subunit of leukocyte integrins. Homozygous CD18 null mice develop chronic dermatitis with extensive facial and submandibular erosions. The phenotype includes elevated neutrophil counts, increased immunoglobulin levels, lymphadenopathy, splenomegaly, and abundant plasma cells in skin, lymph nodes, gut, and kidney. Very few neutrophils were found in spontaneously occurring skin lesions or with an induced toxic dermatitis. Intravital microscopy in CD18 null mice revealed a lack of firm neutrophil attachment to venules in the cremaster muscle in response to N -formyl- methionyl-leucyl-phenylalanine. A severe defect in T cell proliferation was found in the CD18 null mice when T cell receptors were stimulated either by staphylococcal enterotoxin A or by major histocompatibility complex alloantigens demonstrating a greater role of CD11/CD18 integrins in T cell responses than previously documented. The null mice are useful for delineating the functions of CD18 in vivo.