Institution
University of Cologne
Education•Cologne, Germany•
About: University of Cologne is a education organization based out in Cologne, Germany. It is known for research contribution in the topics: Population & Gene. The organization has 32050 authors who have published 66350 publications receiving 2210092 citations. The organization is also known as: Universität zu Köln & Universitatis Coloniensis.
Topics: Population, Gene, Transplantation, Medicine, Cancer
Papers published on a yearly basis
Papers
More filters
••
TL;DR: In this paper, a haemodynamic definition for pulmonary hypertension due to LHD and a three-step pragmatic approach to differential diagnosis are proposed. But, the diagnosis of PH in heart failure with preserved ejection fraction represents the most complex situation, as it may be misdiagnosed with group 1 PH.
Abstract: Pulmonary hypertension (PH) is frequent in left heart disease (LHD), as a consequence of the underlying condition. Significant advances have occurred over the past 5 years since the 5th World Symposium on Pulmonary Hypertension in 2013, leading to a better understanding of PH-LHD, challenges and gaps in evidence. PH in heart failure with preserved ejection fraction represents the most complex situation, as it may be misdiagnosed with group 1 PH. Based on the latest evidence, we propose a new haemodynamic definition for PH due to LHD and a three-step pragmatic approach to differential diagnosis. This includes the identification of a specific “left heart” phenotype and a non-invasive probability of PH-LHD. Invasive confirmation of PH-LHD is based on the accurate measurement of pulmonary arterial wedge pressure and, in patients with high probability, provocative testing to clarify the diagnosis. Finally, recent clinical trials did not demonstrate a benefit in treating PH due to LHD with pulmonary arterial hypertension-approved therapies.
335 citations
••
University of Dundee1, University of Göttingen2, Katholieke Universiteit Leuven3, University of Hamburg4, University of Cologne5, University of Toronto6, University of Nottingham7, St Thomas' Hospital8, VU University Amsterdam9, Ghent University10, University of Southampton11, University College London12, University of Cagliari13, University of Zurich14
TL;DR: A guidelines group of the European Network for Hyperkinetic Disorders (EUNETHYDIS) has reviewed the literature, recruited renowned clinical subspecialists and consulted as a group to examine concerns about the safety of ADHD medications.
Abstract: The safety of ADHD medications is not fully known. Concerns have arisen about both a lack of contemporary-standard information about medications first licensed several decades ago, and signals of possible harm arising from more recently developed medications. These relate to both relatively minor adverse effects and extremely serious issues such as sudden cardiac death and suicidality. A guidelines group of the European Network for Hyperkinetic Disorders (EUNETHYDIS) has therefore reviewed the literature, recruited renowned clinical subspecialists and consulted as a group to examine these concerns. Some of the effects examined appeared to be minimal in impact or difficult to distinguish from risk to untreated populations. However, several areas require further study to allow a more precise understanding of these risks.
335 citations
••
TL;DR: Guided by feedback patterns observed on eBay and other platforms, laboratory experiments are run to investigate how reciprocity can be managed by changes in the way feedback information flows through the system, leading to more accurate reputation information, more trust, and more efficient trade.
Abstract: Reciprocity in feedback giving distorts the production and content of reputation information in a market, hampering trust and trade efficiency. Guided by feedback patterns observed on eBay and other platforms, we run laboratory experiments to investigate how reciprocity can be managed by changes in the way feedback information flows through the system, leading to more accurate reputation information, more trust, and more efficient trade. We discuss the implications for theory building and for managing the redesign of market trust systems.
This paper was accepted by Teck Ho, decision analysis.
335 citations
••
TL;DR: It is reported that the Drosophila gene serpent (srp) encodes the previously described GATA factor ABF, which implies that some aspects of the molecular mechanisms underlying blood cell development as well as endodermal differentiation are early acquisitions of metazoan evolution and may be common to most higher animals.
Abstract: In vertebrates, transcriptional regulators of the GATA family appear to have a conserved function in differentiation and organ development. GATA-1, -2 and -3 are required for different aspects of hematopoiesis, while GATA-4, -5 and -6 are expressed in various organs of endodermal origin, such as intestine and liver, and are implicated in endodermal differentiation. Here we report that the Drosophila gene serpent (srp) encodes the previously described GATA factor ABF. The multiple functions of srp in Drosophila suggest that it is an ortholog of the entire vertebrate Gata family. srp is required for the differentiation and morphogenesis of the endodermal gut. Here we show that it is also essential for Drosophila hematopoiesis and for the formation of the fat body, the insect organ analogous to the liver. These findings imply that some aspects of the molecular mechanisms underlying blood cell development as well as endodermal differentiation are early acquisitions of metazoan evolution and may be common to most higher animals.
335 citations
••
Oslo University Hospital1, Cardiff University2, University of Helsinki3, Leiden University Medical Center4, Royal Melbourne Hospital5, Leipzig University6, University of Bonn7, University of Melbourne8, Aarhus University Hospital9, Aarhus University10, Aalborg University11, University of Barcelona12, Imperial College London13, Central Manchester University Hospitals NHS Foundation Trust14, University of Manchester15, Newcastle University16, University of Vermont17, University Medical Center Groningen18, European Institute of Oncology19, Vita-Salute San Raffaele University20, Karolinska Institutet21, Tel Aviv University22, Sheba Medical Center23, University Hospital of Basel24, Hospital Italiano de Buenos Aires25, University of Cologne26, Dresden University of Technology27, Ludwig Maximilian University of Munich28, University Hospital Bonn29, University Hospital Heidelberg30, German Cancer Research Center31, University of Düsseldorf32, Ruhr University Bochum33, Helsinki University Central Hospital34, Stanford University35, Mayo Clinic36, Lunenfeld-Tanenbaum Research Institute37, University of Hawaii38, Fred Hutchinson Cancer Research Center39, Cedars-Sinai Medical Center40, Copenhagen University Hospital41, Leiden University42, Karolinska University Hospital43, University of Jyväskylä44, University of Oslo45
TL;DR: Management guidelines for Lynch syndrome may require revision in light of these different gene and gender-specific risks and the good prognosis for the most commonly associated cancers.
334 citations
Authors
Showing all 32558 results
Name | H-index | Papers | Citations |
---|---|---|---|
Julie E. Buring | 186 | 950 | 132967 |
Stuart H. Orkin | 186 | 715 | 112182 |
Cornelia M. van Duijn | 183 | 1030 | 146009 |
Dorret I. Boomsma | 176 | 1507 | 136353 |
Frederick W. Alt | 171 | 577 | 95573 |
Donald E. Ingber | 164 | 610 | 100682 |
Klaus Müllen | 164 | 2125 | 140748 |
Klaus Rajewsky | 154 | 504 | 88793 |
Frederik Barkhof | 154 | 1449 | 104982 |
Stefanie Dimmeler | 147 | 574 | 81658 |
Detlef Weigel | 142 | 516 | 84670 |
Hidde L. Ploegh | 135 | 674 | 67437 |
Luca Valenziano | 130 | 437 | 94728 |
Peter Walter | 126 | 841 | 71580 |
Peter G. Martin | 125 | 553 | 97257 |