University of Erlangen-Nuremberg

About: University of Erlangen-Nuremberg is a education organization based out in Erlangen, Bayern, Germany. It is known for research contribution in the topics: Population & Immune system. The organization has 42405 authors who have published 85600 publications receiving 2663922 citations.

Transition Metal‐Catalyzed Asymmetric Hydroamination of Alkenes (AHA)

Abstract: The hydroamination of unsaturated carbon-carbon linkages allows a facile and highly atom-economical access to industrially relevant nitrogen-containing basic and fine chemicals as well as naturally occurring alkaloid skeletons. Significant research efforts have led to the development of efficient catalyst systems for intra- and intermolecular hydroamination reactions. Of particular interest are hydroaminations promoted by chiral catalysts, in which a new chiral center is generated or chiral substrates are kinetically resolved. This review will give an overview on the current state of the art in this rapidly evolving field of catalysis.

The Antiviral Activities of Artemisinin and Artesunate

Abstract: Traditional Chinese medicine commands a unique position among all traditional medicines because of its 5000 years of history. Our own interest in natural products from traditional Chinese medicine was triggered in the 1990s, by artemisinin-type sesquiterpene lactones from Artemisia annua L. As demonstrated in recent years, this class of compounds has activity against malaria, cancer cells, and schistosomiasis. Interestingly, the bioactivity of artemisinin and its semisynthetic derivative artesunate is even broader and includes the inhibition of certain viruses, such as human cytomegalovirus and other members of the Herpesviridae family (e.g., herpes simplex virus type 1 and Epstein-Barr virus), hepatitis B virus, hepatitis C virus, and bovine viral diarrhea virus. Analysis of the complete profile of the pharmacological activities and molecular modes of action of artemisinin and artesunate and their performance in clinical trials will further elucidate the full antimicrobial potential of these versatile pharmacological tools from nature.

Cortical reorganization during recovery from complex regional pain syndrome

Abstract: Objective: To characterize reorganization of the primary somatosensory cortex (S1) during healing process in complex regional pain syndrome (CRPS). Background: Recently, the authors showed extensive reorganization of the S1 cortex contralateral to the CRPS affected side. Predictors for these plastic changes were CRPS pain and the extent of mechanical hyperalgesia. It is unclear how these S1 changes develop following successful therapy. Methods: The authors used magnetic source imaging to explore changes in the cortical representation of digits (D) 1 and 5 in relation to the lower lip on the unaffected and affected CRPS side in 10 patients during a year or more of follow-up. Results: Cortical reorganization reversed coincident with clinical improvement. A reduction of CRPS pain correlated with recovery from cortical reorganization. Conclusions: Changes of the somatotopic map within the S1 cortex may depend on CRPS pain and its recovery.

Robust Beamforming for Secure Communication in Systems with Wireless Information and Power Transfer

Abstract: This paper considers a multiuser multiple-input single-output (MISO) downlink system with simultaneous wireless information and power transfer. In particular, we focus on secure communication in the presence of passive eavesdroppers and potential eavesdroppers (idle legitimate receivers). We study the design of a resource allocation algorithm minimizing the total transmit power for the case when the legitimate receivers are able to harvest energy from radio frequency signals. Our design advocates the dual use of both artificial noise and energy signals in providing secure communication and facilitating efficient wireless energy transfer. The algorithm design is formulated as a non-convex optimization problem. The problem formulation takes into account artificial noise and energy signal generation for protecting the transmitted information against both considered types of eavesdroppers when imperfect channel state information (CSI) of the potential eavesdroppers and no CSI of the passive eavesdroppers are available at the transmitter. In light of the intractability of the problem, we reformulate the considered problem by replacing a non-convex probabilistic constraint with a convex deterministic constraint. Then, a semi-definite programming (SDP) relaxation approach is adopted to obtain the optimal solution for the reformulated problem. Furthermore, we propose a suboptimal resource allocation scheme with low computational complexity for providing communication secrecy and facilitating efficient energy transfer. Simulation results demonstrate a close-to-optimal performance achieved by the proposed schemes and significant transmit power savings by optimization of the artificial noise and energy signal generation.