Institution
University of Erlangen-Nuremberg
Education•Erlangen, Bayern, Germany•
About: University of Erlangen-Nuremberg is a education organization based out in Erlangen, Bayern, Germany. It is known for research contribution in the topics: Population & Immune system. The organization has 42405 authors who have published 85600 publications receiving 2663922 citations.
Topics: Population, Immune system, Catalysis, Medicine, Computer science
Papers published on a yearly basis
Papers
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The Breast Cancer Research Foundation1, Netherlands Cancer Institute2, St James's University Hospital3, Carlos III Health Institute4, Autonomous University of Madrid5, German Cancer Research Center6, Leiden University7, University of Erlangen-Nuremberg8, Trinity College, Dublin9, University of Manchester10, Imperial College London11, University of Nantes12, Erasmus University Rotterdam13, University of Glasgow14, Max Delbrück Center for Molecular Medicine15, French Institute of Health and Medical Research16, University of Vienna17, University of London18, Cancer Research UK19
TL;DR: The use of cytokeratin staining in combination with ER and morphology provides a more accurate predictor of BRCA1 mutation status than previously available, that may be useful in selecting patients for BRCa1 mutation testing.
Abstract: Purpose: To investigate the proportion of breast cancers arising inpatients with germ line BRCA1 and BRCA2 mutations expressing basal markers and developing predictive tests for identification of high-risk patients. Experimental Design: Histopathologic material from 182 tumors in BRCA1 mutation carriers, 63 BRCA2 carriers, and 109 controls, collected as part of the international Breast Cancer Linkage Consortium were immunohistochemically stained for CK14, CK5/6, CK17, epidermal growth factor receptor (EGFR), and osteonectin. Results: All five basal markers were commoner in BRCA1 tumors than in control tumors (CK14: 61% versus 12%; CK5/6: 58% versus 7%; CK17: 53% versus 10%; osteonectin: 43% versus 19%; EGFR: 67% versus 21%; P < 0.0001 in each case). In a multivariate analysis, CK14, CK5/6, and estrogen receptor (ER) remained significant predictors of BRCA1 carrier status. In contrast, the frequency of basal markers in BRCA2 tumors did not differ significant from controls. Conclusion: The use of cytokeratin staining in combination with ER and morphology provides a more accurate predictor of BRCA1 mutation status than previously available, that may be useful in selecting patients for BRCA1 mutation testing. The high percentage of BRCA1 cases positive for EGFR suggests that specific anti-tyrosine kinase therapy may be of potential benefit in these patients.
642 citations
Journal Article•
Vanderbilt University Medical Center1, Duke University2, St. Joseph Hospital3, Henry Ford Health System4, University of Tennessee5, University of Alabama at Birmingham6, Harvard University7, Vanderbilt University8, Yale University9, University of Erlangen-Nuremberg10, Mercy Medical Center (Baltimore, Maryland)11
TL;DR: This list of hospitals and institutes that specialise in nuclear medicine, including Vanderbilt University Medical Center, Durham, North Carolina, and the Institute of Medical Physics, Erlangen-Nurnberg, Germany, are represented.
Abstract: The purpose of these guidelines is to assist physicians in recommending, performing, interpreting, and reporting the results of 18F-FDG PET/CT for oncologic imaging of adult and pediatric patients.
PET is a tomographic scintigraphic technique in which a computer-generated image of local radioactive
640 citations
TL;DR: Freeform optics is the next generation of modern optics, bringing advantages of excellent optical performance and system integration as mentioned in this paper, and finds wide applications in various fields, such as new energy, illumination, aerospace and biomedical engineering.
638 citations
TL;DR: Among individuals without known CAD, nonobstructive and obstructive CAD by CCTA are associated with higher rates of mortality, with risk profiles differing for age and sex, and absence of CAD is associated with a very favorable prognosis.
638 citations
TL;DR: The authors in this paper reviewed the interdisciplinary field of biocompatible implant surfaces from the viewpoint of materials science, biochemistry and cell biology, and provided an overview on basic information about bulk and surface properties of implant surfaces.
637 citations
Authors
Showing all 42831 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Hermann Brenner | 151 | 1765 | 145655 |
| Richard B. Devereux | 144 | 962 | 116403 |
| Manfred Paulini | 141 | 1791 | 110930 |
| Daniel S. Berman | 141 | 1363 | 86136 |
| Peter Lang | 140 | 1136 | 98592 |
| Joseph Sodroski | 138 | 542 | 77070 |
| Richard J. Johnson | 137 | 880 | 72201 |
| Jun Lu | 135 | 1526 | 99767 |
| Michael Schmitt | 134 | 2007 | 114667 |
| Jost B. Jonas | 132 | 1158 | 166510 |
| Andreas Mussgiller | 127 | 1059 | 73778 |
| Matthew J. Budoff | 125 | 1449 | 68115 |
| Stefan Funk | 125 | 506 | 56955 |
| Markus F. Neurath | 124 | 934 | 62376 |
| Jean-Marie Lehn | 123 | 1054 | 84616 |