Institution
University of Erlangen-Nuremberg
Education•Erlangen, Bayern, Germany•
About: University of Erlangen-Nuremberg is a education organization based out in Erlangen, Bayern, Germany. It is known for research contribution in the topics: Population & Immune system. The organization has 42405 authors who have published 85600 publications receiving 2663922 citations.
Topics: Population, Immune system, Catalysis, Medicine, Computer science
Papers published on a yearly basis
Papers
More filters
••
TL;DR: This paper reviews the current knowledge of sucrose transporter physiology and molecular biology and describes how sucrose transport depends on the activity of plasma membrane‐localized, energy dependent, H+‐symporting carrier proteins.
390 citations
••
TL;DR: In this article, the effects of fly ash on the hydration of ordinary Portland cement pastes were investigated over a hydration time of 550 days and the results were compared with a reference blend of OPC containing 50% of inert quartz powder allowing the distinction between "filler effect" and pozzolanic reaction.
389 citations
••
TL;DR: Among the effects are induction of metallo-proteinases, chemotaxis, angiogenesis and inhibition of inflammation as well as the inhibition of bone marrow stem cell proliferation, nothing is known about the molecular mechanisms mediating the effects attributed to extracellular beta-thymosins.
389 citations
••
TL;DR: It is demonstrated that IgG1 immune complexes, the inhibitory IgG receptor FcγRIIB and the C-type lectin–like receptor dectin-1 suppress C5a receptor (C5aR) functions, and galactosylation of IgG N-glycans is crucial for this inhibitory property of Igg1 ICs.
Abstract: Complement is an ancient danger-sensing system that contributes to host defense, immune surveillance and homeostasis1. C5a and its G protein–coupled receptor mediate many of the proinflammatory properties of complement2. Despite the key role of C5a in allergic asthma3, autoimmune arthritis4, sepsis5 and cancer6, knowledge about its regulation is limited. Here we demonstrate that IgG1 immune complexes (ICs), the inhibitory IgG receptor FcγRIIB and the C-type lectin–like receptor dectin-1 suppress C5a receptor (C5aR) functions. IgG1 ICs promote the association of FcγRIIB with dectin-1, resulting in phosphorylation of Src homology 2 domain–containing inositol phosphatase (SHIP) downstream of FcγRIIB and spleen tyrosine kinase downstream of dectin-1. This pathway blocks C5aR-mediated ERK1/2 phosphorylation, C5a effector functions in vitro and C5a-dependent inflammatory responses in vivo, including peritonitis and skin blisters in experimental epidermolysis bullosa acquisita. Notably, high galactosylation of IgG N-glycans is crucial for this inhibitory property of IgG1 ICs, as it promotes the association between FcγRIIB and dectin-1. Thus, galactosylated IgG1 and FcγRIIB exert anti-inflammatory properties beyond their impact on activating FcγRs.
389 citations
••
TL;DR: In this paper, the anodic formation of nanoporous TiO2 on titanium was investigated in Na2SO4 electrolytes containing low concentrations of NaF (0.1-1/1/5%).
388 citations
Authors
Showing all 42831 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hermann Brenner | 151 | 1765 | 145655 |
Richard B. Devereux | 144 | 962 | 116403 |
Manfred Paulini | 141 | 1791 | 110930 |
Daniel S. Berman | 141 | 1363 | 86136 |
Peter Lang | 140 | 1136 | 98592 |
Joseph Sodroski | 138 | 542 | 77070 |
Richard J. Johnson | 137 | 880 | 72201 |
Jun Lu | 135 | 1526 | 99767 |
Michael Schmitt | 134 | 2007 | 114667 |
Jost B. Jonas | 132 | 1158 | 166510 |
Andreas Mussgiller | 127 | 1059 | 73778 |
Matthew J. Budoff | 125 | 1449 | 68115 |
Stefan Funk | 125 | 506 | 56955 |
Markus F. Neurath | 124 | 934 | 62376 |
Jean-Marie Lehn | 123 | 1054 | 84616 |