University of Erlangen-Nuremberg

About: University of Erlangen-Nuremberg is a education organization based out in Erlangen, Bayern, Germany. It is known for research contribution in the topics: Population & Immune system. The organization has 42405 authors who have published 85600 publications receiving 2663922 citations.

Quantum squeezing of motion in a mechanical resonator

Abstract: According to quantum mechanics, a harmonic oscillator can never be completely at rest. Even in the ground state, its position will always have fluctuations, called the zero-point motion. Although the zero-point fluctuations are unavoidable, they can be manipulated. Using microwave frequency radiation pressure, we have manipulated the thermal fluctuations of a micrometer-scale mechanical resonator to produce a stationary quadrature-squeezed state with a minimum variance of 0.80 times that of the ground state. We also performed phase-sensitive, back-action evading measurements of a thermal state squeezed to 1.09 times the zero-point level. Our results are relevant to the quantum engineering of states of matter at large length scales, the study of decoherence of large quantum systems, and for the realization of ultrasensitive sensing of force and motion.

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

Abstract: Human cytochrome P-450IIE1 has been implicated in the oxidation of a number of substrates, including protoxins and -carcinogens. To date, no drugs have been identified that are exclusive substrates for the protein and are applicable for use as noninvasive probes of the in vivo function of the enzyme in humans. Chlorzoxazone was found to be oxidized only to 6-hydroxychlorzoxazone in human liver microsomes. Results of steady-state kinetics are consistent with the view that only a single enzyme catalyzes the reaction. The microsomal reaction was strongly inhibited by rabbit anti-P-450IIE1 and, in a competitive manner, by known P-450IIE1 substrates. Rates of chlorzoxazone 6-hydroxylation in different human liver microsomal preparations were well correlated with levels of immunochemically measured P-450IIE1 and rates of (CH3)2NNO oxidation. Chlorzoxazone 6-hydroxylation was also found to be catalyzed by purified human liver P-450IIE1. These results provide strong evidence that P-450IIE1 is the primary catalyst of chlorzoxazone 6-hydroxylation in human liver. Rates of chlorzoxazone 6-hydroxylation vary considerably among human liver samples, and chlorzoxazone 6-hydroxylation may have potential use as a noninvasive probe in estimating the in vivo expression of human P-450IIE1 and its significance as a risk factor in the toxicity and carcinogenicity of a number of solvents, nitrosamines, and drugs.

Release of High Mobility Group Box 1 by Dendritic Cells Controls T Cell Activation via the Receptor for Advanced Glycation End Products

Abstract: High mobility group box 1 (HMGB1) is an abundant and conserved nuclear protein that is released by necrotic cells and acts in the extracellular environment as a primary proinflammatory signal. In this study we show that human dendritic cells, which are specialized in Ag presentation to T cells, actively release their own HMGB1 into the extracellular milieu upon activation. This secreted HMGB1 is necessary for the up-regulation of CD80, CD83, and CD86 surface markers of human dendritic cells and for IL-12 production. The HMGB1 secreted by dendritic cells is also required for the clonal expansion, survival, and functional polarization of naive T cells. Using neutralizing Abs and receptor for advanced glycation end product-deficient (RAGE(-/-)) cells, we demonstrate that RAGE is required for the effect of HMGB1 on dendritic cells. HMGB1/RAGE interaction results in downstream activation of MAPKs and NF-kappaB. The use of an ancient signal of necrosis, HMGB1, by dendritic cells to sustain their own maturation and for activation of T lymphocytes represents a profitable evolutionary mechanism.

Robust Beamforming for Secure Communication in Systems With Wireless Information and Power Transfer

Abstract: This paper considers a multiuser multiple-input single-output (MISO) downlink system with simultaneous wireless information and power transfer. In particular, we focus on secure communication in the presence of passive eavesdroppers and potential eavesdroppers (idle legitimate receivers). We study the design of a resource allocation algorithm minimizing the total transmit power for the case when the legitimate receivers are able to harvest energy from radio frequency signals. Our design advocates the dual use of both artificial noise and energy signals in providing secure communication and facilitating efficient wireless energy transfer. The algorithm design is formulated as a non-convex optimization problem. The problem formulation takes into account artificial noise and energy signal generation for protecting the transmitted information against both considered types of eavesdroppers when imperfect channel state information (CSI) of the potential eavesdroppers and no CSI of the passive eavesdroppers are available at the transmitter. Besides, the problem formulation also takes into account different quality of service (QoS) requirements: a minimum required signal-to-interference-plus-noise ratio (SINR) at the desired receiver; maximum tolerable SINRs at the potential eavesdroppers; a minimum required outage probability at the passive eavesdroppers; and minimum required heterogeneous amounts of power transferred to the idle legitimate receivers. In light of the intractability of the problem, we reformulate the considered problem by replacing a non-convex probabilistic constraint with a convex deterministic constraint. Then, a semi-definite programming (SDP) relaxation approach is adopted to obtain the optimal solution for the reformulated problem. Furthermore, we propose a suboptimal resource allocation scheme with low computational complexity for providing communication secrecy and facilitating efficient energy transfer. Simulation results demonstrate the close-to-optimal performance of the proposed schemes and significant transmit power savings by optimization of the artificial noise and energy signal generation.

Visible light photodegradation of 4-chlorophenol with a coke-containing titanium dioxide photocatalyst

Abstract: Photocatalysts based on titanium dioxide have been prepared by a modified sol–gel process using different alkoxide precursors. Depending on the precursor and the calcination temperature of the gels, carbon-containing catalysts with large surface areas, capable to photodegrade p-chlorophenol (4CP) with visible light (λ>400 nm), have been obtained. Photodegradation and mineralisation were confirmed by HPLC and TOC measurements. The catalysts were characterised by physisorption of argon, elemental analysis, EPR, UV/VIS, X-ray powder diffraction (XRD), FT-IR and high-resolution transmission electron microscopy (HRTEM). A highly condensed, carbonaceous species formed during calcination is responsible for the photosensitisation. When used as a photoelectrode, the appearance of a photocurrent indicated the semiconductor nature of these novel materials. The catalysts exhibit a surprisingly good long-time stability despite of the carbonaceous nature of the sensitising species. It is also shown, that commercially available TiO2 can be photosensitised by impregnation with suitable alcohols followed by pyrolysis.