University of Jyväskylä

About: University of Jyväskylä is a education organization based out in Jyvaskyla, Finland. It is known for research contribution in the topics: Population & Context (language use). The organization has 8066 authors who have published 25168 publications receiving 725033 citations. The organization is also known as: Jyväskylän yliopisto & Kasvatusopillinen korkeakoulu.

Heavy-ion collisions at the LHC-Last call for predictions

Abstract: This writeup is a compilation of the predictions for the forthcoming Heavy Ion Program at the Large Hadron Collider, as presented at the CERN Theory Institute 'Heavy Ion Collisions at the LHC - Last Call for Predictions', held from 14th May to 10th June 2007.

Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B.

Abstract: Both the aging of animals and the senescence of cultured cells involve an altered pattern of gene expression, suggesting changes in transcription factor regulation. We studied age-related changes in transcription factors nuclear factor (NF)-kappa B, activator protein factor-1 (AP-1) and Sp-1 by using electrophoretic mobility shift binding assays; we also analysed changes in the protein components of NF-kappa B complex with Western blot assays. Nuclear and cytoplasmic extracts were prepared from heart, liver, kidney and brain of young adult and old NMRI mice and Wistar rats as well as from presenescent, senescent and simian virus 40-immortalized human WI-38 fibroblasts. Aging of both mice and rats induced a strong and consistent increase in the nuclear binding activity of NF-kappa B factor in all tissues studied, whereas those of AP-1 and Sp-1 decreased, e.g. in liver. Protein levels of p50, p52 and p65 components of the NF-kappa B complex did not show any age-associated changes in the cytoplasmic fraction but in the nuclear fraction the level of p52 strongly increased in heart and liver during aging. The protein levels of inhibitory I kappa B-alpha and Bcl-3 components were not affected by aging in any of the tissues studied. Replicative cellular senescence of human WI-38 fibroblasts induced a strong decrease in nuclear NF-kappa B, AP-1 and Sp-1 binding activities. Protein levels of p50 and p52 components of NF-kappa B complex were decreased in the nuclear fraction of senescent WI-38 fibroblasts but in the cytoplasm of senescent fibroblasts the level of p65 protein was increased. Cellular senescence also slightly decreased the protein levels of I kappa B-alpha and Bcl-3. Transfection assays with NF-kappa B-enhancer-driven chloramphenicol acetyltransferase reporter gene showed a significant down-regulation of NF-kappa B promoter activity in senescent WI-38 fibroblasts. Results suggest that the aging process might be regulated differently in tissues and cultured fibroblasts, perhaps reflecting differences between mitotic and post-mitotic cells. In tissues, aging seems to involve specific changes in the regulation of NF-kappa B components and perhaps also changes in the DNA-binding affinities of the NF-kappa B complex.

Hidden oscillations in mathematical model of drilling system actuated by induction motor with a wound rotor

Abstract: This work is devoted to the investigation of mathematical models of drilling systems described by ordinary differential equations. Here, we continue the study done by the researchers from Eindhoven where the two-mass mathematical model of a drilling system has been investigated (Mihajlovic et al. J. Dyn. Syst. Meas. Control 126(4): 709–720, 2004; de Bruin et al. Automatica 45(2): 405–415, 2009). The modified version of this model, which takes into account a full description of an induction motor, is studied. It is shown that such complex effects as hidden oscillations may appear in these kinds of systems. These effects may lead to drill string failures and breakdowns.

Event-by-event fluctuations in a perturbative QCD + saturation + hydrodynamics model: Determining QCD matter shear viscosity in ultrarelativistic heavy-ion collisions

Abstract: This paper introduces an event-by-event perturbative QCD plus saturation framework for the initial state of high-energy heavy-ion collisions and evolves the matter using dissipative fluid dynamics. The results favor a ratio of shear viscosity-to-entropy density that has a minimum near a temperature of 150 MeV, in line with theoretical expectations.

Smart semantic middleware for the internet of things

Abstract: As ubiquitous systems become increasingly complex, traditional solutions to manage and control them reach their limits and pose a need for self-manageability. Also, heterogeneity of the ubiquitous components, standards, data formats, etc, creates significant obstacles for interoperability in such complex systems. The promising technologies to tackle these problems are the Semantic technologies, for interoperability, and the Agent technologies for management of complex systems. This paper describes our vision of a middleware for the Internet of Things, which will allow creation of self-managed complex systems, in particular industrial ones, consisting of distributed and heterogeneous components of different nature. We also present an analysis of issues to be resolved to realize such a middleware.