University of Massachusetts Amherst

About: University of Massachusetts Amherst is a education organization based out in Amherst Center, Massachusetts, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 37274 authors who have published 83965 publications receiving 3834996 citations. The organization is also known as: UMass Amherst & Massachusetts State College.

Surface wrinkles for smart adhesion

Abstract: to develop synthetic analogs as“smart” adhesives, that is, where the geometry of the patternscan tailor the adhesion of the material. However, there arecurrently two limitations in the design of patterned adhesives.First, because of either materials selection or geometric de-sign, the adhesive properties are not always reversible overthe course of multiple attachment–detachment cycles.

Hoard: a scalable memory allocator for multithreaded applications

Abstract: Parallel, multithreaded C and C++ programs such as web servers, database managers, news servers, and scientific applications are becoming increasingly prevalent. For these applications, the memory allocator is often a bottleneck that severely limits program performance and scalability on multiprocessor systems. Previous allocators suffer from problems that include poor performance and scalability, and heap organizations that introduce false sharing. Worse, many allocators exhibit a dramatic increase in memory consumption when confronted with a producer-consumer pattern of object allocation and freeing. This increase in memory consumption can range from a factor of P (the number of processors) to unbounded memory consumption.This paper introduces Hoard, a fast, highly scalable allocator that largely avoids false sharing and is memory efficient. Hoard is the first allocator to simultaneously solve the above problems. Hoard combines one global heap and per-processor heaps with a novel discipline that provably bounds memory consumption and has very low synchronization costs in the common case. Our results on eleven programs demonstrate that Hoard yields low average fragmentation and improves overall program performance over the standard Solaris allocator by up to a factor of 60 on 14 processors, and up to a factor of 18 over the next best allocator we tested.

Side effects of methylphenidate in children with attention deficit hyperactivity disorder: a systemic, placebo-controlled evaluation.

Abstract: The frequency and severity of 17 side effects presumably associated with stimulant medication were assessed during a rigorous, triple-blind, placebo-controlled, crossover evaluation of methylphenidate, 0.3 and 0.5 mg/kg twice a day, in 83 children with attention deficit hyperactivity disorder. Side effects were rated by parents and teachers at the end of each weekly drug condition. Three children (3.6%) had side effects that were sufficiently serious to warrant immediate discontinuation of medication. Parent ratings indicated that only the side effects of decreased appetite, insomnia, stomachaches, and headaches increased significantly in frequency and severity during the two active medication doses as compared with the placebo condition. Fewer than half of the children experienced these side effects and among those who did, ratings of mean severity remained in the mild range. Teacher ratings showed little change over drug conditions, except on ratings of staring, sadness, and anxiety, which declined with increasing dose of medication. Parent ratings indicated that only the side effects of decreased appetite, insomnia, stomachaches, and headaches increased significantly in frequency and severity during the two active medication doses as compared with the placebo condition. Fewer than half of the children experienced these side effects and among those who did, ratings of mean severity remained in the mild range. Teacher ratings showed little change over drug conditions, except on ratings of staring, sadness, and anxiety, which declined with increasing dose of medication. Surprisingly, a high frequency of these behavior side effects were reported during the placebo condition. Stimulant medication within this therapeutic range, therefore, results in few, generally mild side effects.(ABSTRACT TRUNCATED AT 250 WORDS)

Inhibitory potential of herb, fruit, and fungal-enriched cheese against key enzymes linked to type 2 diabetes and hypertension

Abstract: In the current study, three different types of cheese, cheddar, feta, and Roquefort, were screened to determine the variations in phenolic-linked antioxidant activity and the potential to inhibit key enzymes relevant to type 2 diabetes and related hypertension. The cheese samples were assayed for total phenolic content, related antioxidant activity, and inhibition of α-glucosidase, pancreatic α-amylase inhibitory activity, and the angiotensin-converting enzyme (ACE)-I inhibitory activity. The three fungal-enriched Roquefort cheese samples had the highest total phenolic content. The phenolic content in the herb cheese was slightly but not significantly higher compared to plain cheese. Roquefort cheese samples had the highest antioxidant-linked DPPH (free radical) scavenging activity and as expected DPPH radical scavenging activity was higher in the herb cheese compared to plain cheese. All samples had some α-glucosidase and α-amylase inhibitory activities, with cranberry-enriched cheese having the highest activities. However, no correlation to soluble phenolic content was observed. All the cheese samples had very high anti-ACE-I inhibitory activity, indicating no correlation to phenolic content and activity was even high in 10× diluted samples. The highest ACE-I inhibitory activity was observed in plain and herb-enriched cheddar cheese as well as cranberry-enriched cheese. These studies indicate that cranberry-enriched cheese had the best potential for inhibition of α-glucosidase and α-amylase relevant for type 2 diabetes management, whereas any cheese product had potential for ACE-I inhibition linked to hypertension management, indicating likely the role of other factors such as peptides from cheese fermentation. Industrial relevance This research is focused on screening of different types of commercial plain, herbal, fruit, and fungal-enriched to provide a strong biochemical rationale for further design of functional cheese products for anti-type 2 diabetic and relevant hypertension management. A better understanding of these functional attributes provides a strong biochemical rationale for design in vivo and clinical studies from which right design of functional food can be established.