Institution
University of Massachusetts Amherst
Education•Amherst Center, Massachusetts, United States•
About: University of Massachusetts Amherst is a education organization based out in Amherst Center, Massachusetts, United States. It is known for research contribution in the topics: Population & Galaxy. The organization has 37274 authors who have published 83965 publications receiving 3834996 citations. The organization is also known as: UMass Amherst & Massachusetts State College.
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TL;DR: The spatial relation between mitochondria and endoplasmic reticulum in living HeLa cells was analyzed at high resolution in three dimensions with two differently colored, specifically targeted green fluorescent proteins to emphasize the importance of cell architecture and the distribution of organelles in regulation of Ca2+ signaling.
Abstract: The spatial relation between mitochondria and endoplasmic reticulum (ER) in living HeLa cells was analyzed at high resolution in three dimensions with two differently colored, specifically targeted green fluorescent proteins. Numerous close contacts were observed between these organelles, and mitochondria in situ formed a largely interconnected, dynamic network. A Ca2+-sensitive photoprotein targeted to the outer face of the inner mitochondrial membrane showed that, upon opening of the inositol 1,4,5-triphosphate (IP3)-gated channels of the ER, the mitochondrial surface was exposed to a higher concentration of Ca2+ than was the bulk cytosol. These results emphasize the importance of cell architecture and the distribution of organelles in regulation of Ca2+ signaling.
2,129 citations
TL;DR: A simple, robust, chemical route to the fabrication of ultrahigh-density arrays of nanopores with high aspect ratios using the equilibrium self-assembled morphology of asymmetric diblock copolymers is shown.
Abstract: We show a simple, robust, chemical route to the fabrication of ultrahigh-density arrays of nanopores with high aspect ratios using the equilibrium self-assembled morphology of asymmetric diblock copolymers. The dimensions and lateral density of the array are determined by segmental interactions and the copolymer molecular weight. Through direct current electrodeposition, we fabricated vertical arrays of nanowires with densities in excess of 1.9 x 10(11) wires per square centimeter. We found markedly enhanced coercivities with ferromagnetic cobalt nanowires that point toward a route to ultrahigh-density storage media. The copolymer approach described is practical, parallel, compatible with current lithographic processes, and amenable to multilayered device fabrication.
2,106 citations
Space Telescope Science Institute1, University of California, Santa Cruz2, Johns Hopkins University3, Rutgers University4, Durham University5, University of Nottingham6, Harvard University7, University of Innsbruck8, University of Michigan9, DSM10, University of Edinburgh11, University of Massachusetts Amherst12, California Institute of Technology13, UK Astronomy Technology Centre14, University of California, Irvine15, Swinburne University of Technology16, University of Arizona17, Goddard Space Flight Center18, The Catholic University of America19, Hebrew University of Jerusalem20, University of Victoria21, University of California, Berkeley22, Texas A&M University23, University of Notre Dame24, Carnegie Institution for Science25, Smithsonian Institution26, Yale University27, University of Missouri–Kansas City28, University of California, Riverside29, Max Planck Society30, University of Pittsburgh31, Inter-University Centre for Astronomy and Astrophysics32, University of Barcelona33, European Southern Observatory34, University of Minnesota35, National Research Council36, Western Kentucky University37, Stanford University38, Atacama Large Millimeter Submillimeter Array39, University of Missouri40
TL;DR: The Cosmic Assembly Near-IR Deep Extragalactic Legacy Survey (CANDELS) as discussed by the authors was designed to document the first third of galactic evolution, from z approx. 8 - 1.5 to test their accuracy as standard candles for cosmology.
Abstract: The Cosmic Assembly Near-IR Deep Extragalactic Legacy Survey (CANDELS) is designed to document the first third of galactic evolution, from z approx. 8 - 1.5. It will image > 250,000 distant galaxies using three separate cameras on the Hubble Space Tele8cope, from the mid-UV to near-IR, and will find and measure Type Ia supernovae beyond z > 1.5 to test their accuracy as standard candles for cosmology. Five premier multi-wavelength sky regions are selected, each with extensive ancillary data. The use of five widely separated fields mitigates cosmic variance and yields statistically robust and complete samples of galaxies down to a stellar mass of 10(exp 9) solar mass to z approx. 2, reaching the knee of the UV luminosity function of galaxies to z approx. 8. The survey covers approximately 800 square arc minutes and is divided into two parts. The CANDELS/Deep survey (5(sigma) point-source limit H =27.7mag) covers approx. 125 square arcminutes within GOODS-N and GOODS-S. The CANDELS/Wide survey includes GOODS and three additional fields (EGS, COSMOS, and UDS) and covers the full area to a 50(sigma) point-source limit of H ? or approx. = 27.0 mag. Together with the Hubble Ultradeep Fields, the strategy creates a three-tiered "wedding cake" approach that has proven efficient for extragalactic surveys. Data from the survey are non-proprietary and are useful for a wide variety of science investigations. In this paper, we describe the basic motivations for the survey, the CANDELS team science goals and the resulting observational requirements, the field selection and geometry, and the observing design.
2,088 citations
TL;DR: An overview of chemical catalytic transformations of biomass-derived oxygenated feedstocks in the liquid phase to value-added chemicals and fuels is presented, with specific examples emphasizing the development of catalytic processes based on an understanding of the fundamental reaction chemistry.
Abstract: Biomass has the potential to serve as a sustainable source of energy and organic carbon for our industrialized society. The focus of this Review is to present an overview of chemical catalytic transformations of biomass-derived oxygenated feedstocks (primarily sugars and sugar-alcohols) in the liquid phase to value-added chemicals and fuels, with specific examples emphasizing the development of catalytic processes based on an understanding of the fundamental reaction chemistry. The key reactions involved in the processing of biomass are hydrolysis, dehydration, isomerization, aldol condensation, reforming, hydrogenation, and oxidation. Further, it is discussed how ideas based on fundamental chemical and catalytic concepts lead to strategies for the control of reaction pathways and process conditions to produce H(2)/CO(2) or H(2)/CO gas mixtures by aqueous-phase reforming, to produce furan compounds by selective dehydration of carbohydrates, and to produce liquid alkanes by the combination of aldol condensation and dehydration/hydrogenation processes.
2,063 citations
2,014 citations
Authors
Showing all 37601 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| George M. Whitesides | 240 | 1739 | 269833 |
| Joan Massagué | 189 | 408 | 149951 |
| David H. Weinberg | 183 | 700 | 171424 |
| David L. Kaplan | 177 | 1944 | 146082 |
| Michael I. Jordan | 176 | 1016 | 216204 |
| James F. Sallis | 169 | 825 | 144836 |
| Bradley T. Hyman | 169 | 765 | 136098 |
| Anton M. Koekemoer | 168 | 1127 | 106796 |
| Derek R. Lovley | 168 | 582 | 95315 |
| Michel C. Nussenzweig | 165 | 516 | 87665 |
| Alfred L. Goldberg | 156 | 474 | 88296 |
| Donna Spiegelman | 152 | 804 | 85428 |
| Susan E. Hankinson | 151 | 789 | 88297 |
| Bernard Moss | 147 | 830 | 76991 |
| Roger J. Davis | 147 | 498 | 103478 |