University of Minnesota

About: University of Minnesota is a education organization based out in Minneapolis, Minnesota, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 117432 authors who have published 257986 publications receiving 11944239 citations. The organization is also known as: University of Minnesota, Twin Cities & University of Minnesota-Twin Cities.

The roles of segmental and tandem gene duplication in the evolution of large gene families in Arabidopsis thaliana

Abstract: Background Most genes in Arabidopsis thaliana are members of gene families. How do the members of gene families arise, and how are gene family copy numbers maintained? Some gene families may evolve primarily through tandem duplication and high rates of birth and death in clusters, and others through infrequent polyploidy or large-scale segmental duplications and subsequent losses.

Mining sequential patterns by pattern-growth: the PrefixSpan approach

Abstract: Sequential pattern mining is an important data mining problem with broad applications. However, it is also a difficult problem since the mining may have to generate or examine a combinatorially explosive number of intermediate subsequences. Most of the previously developed sequential pattern mining methods, such as GSP, explore a candidate generation-and-test approach [R. Agrawal et al. (1994)] to reduce the number of candidates to be examined. However, this approach may not be efficient in mining large sequence databases having numerous patterns and/or long patterns. In this paper, we propose a projection-based, sequential pattern-growth approach for efficient mining of sequential patterns. In this approach, a sequence database is recursively projected into a set of smaller projected databases, and sequential patterns are grown in each projected database by exploring only locally frequent fragments. Based on an initial study of the pattern growth-based sequential pattern mining, FreeSpan [J. Han et al. (2000)], we propose a more efficient method, called PSP, which offers ordered growth and reduced projected databases. To further improve the performance, a pseudoprojection technique is developed in PrefixSpan. A comprehensive performance study shows that PrefixSpan, in most cases, outperforms the a priori-based algorithm GSP, FreeSpan, and SPADE [M. Zaki, (2001)] (a sequential pattern mining algorithm that adopts vertical data format), and PrefixSpan integrated with pseudoprojection is the fastest among all the tested algorithms. Furthermore, this mining methodology can be extended to mining sequential patterns with user-specified constraints. The high promise of the pattern-growth approach may lead to its further extension toward efficient mining of other kinds of frequent patterns, such as frequent substructures.

Polymer-polymer phase behavior.

Abstract: Different polymers can be combined into a single material in many ways, which can lead to a wide range of phase behaviors that directly influence the associated physical properties and ultimate applications. Four factors control polymer-polymer phase behavior: choice of monomers, molecular architecture, composition, and molecular size. Current theories and experiments that deal with the equilibrium thermodynamics and non-equilibrium dynamics of polymer mixtures are described in terms of these experimentally accessible parameters. Two representative molecular architectures, binary linear homopolymer mixtures and diblock copolymers, exhibiting macrophase separation and microphase segregation, respectively, are examined in some detail. Although these model systems are fairly well understood, a myriad of mixing scenarios, with both existing and unrealized materials applications, remain unexplored at a fundamental level.

A randomized trial of aspirin to prevent colorectal adenomas

Abstract: Background Laboratory and epidemiologic data suggest that aspirin has an antineoplastic effect in the large bowel. Methods We performed a randomized, double-blind trial of aspirin as a chemopreventive agent against colorectal adenomas. We randomly assigned 1121 patients with a recent history of histologically documented adenomas to receive placebo (372 patients), 81 mg of aspirin (377 patients), or 325 mg of aspirin (372 patients) daily. According to the protocol, follow-up colonoscopy was to be performed approximately three years after the qualifying endoscopy. We compared the groups with respect to the risk of one or more neoplasms (adenomas or colorectal cancer) at least one year after randomization using generalized linear models to compute risk ratios and 95 percent confidence intervals. Results Reported adherence to study medications and avoidance of nonsteroidal antiinflammatory drugs were excellent. Follow-up colonoscopy was performed at least one year after randomization in 1084 patients (97 perc...

A symmetry problem in potential theory

Abstract: The proof of this result is given in Section 1 ; in Section 3 we give various generalizations to elliptic differential equations other than (1). Before turning to the detailed arguments it will be of interest to discuss the physical motivation for the problem itself. Consider a viscous incompressible fluid moving in straight parallel streamlines through a straight pipe of given cross sectional form f2. If we fix rectangular coordinates in space with the z axis directed along the pipe, it is well known that the flow velocity u is then a function of x, y alone satisfying the Poisson differential equation (for n = 2) A u = A i n f2