University of Minnesota

About: University of Minnesota is a education organization based out in Minneapolis, Minnesota, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 117432 authors who have published 257986 publications receiving 11944239 citations. The organization is also known as: University of Minnesota, Twin Cities & University of Minnesota-Twin Cities.

Polyisoprene-Polystyrene Diblock Copolymer Phase Diagram near the Order-Disorder Transition

Abstract: The phase behavior of ten polyisoprene-polystyrene (PI-PS) diblock copolymers, spanning the composition range from 0.24 to 0.82 polyisoprene volume fraction (f PI ), has been studied near the order-disorder transition (ODT). Dynamic mechanical spectroscopy, transmission electron microscopy, and neutron and X-ray scattering have been used to characterize phase transition temperatures and ordered state symmetries. Five distinct microstructures were observed for this chemical system : spheres, hexagonally packed cylinders (HEX), lamellae (LAM), hexagonally perforated layers (HPL), and a bicontinuous cubic phase having an Ia3d space group symmetry. The bicontinuous Ia3d phase only occurs in the vicinity of the ODT between the HEX and LAM states at compositions of 0.65 ≤ f pI ≤ 0.68 and 0.36 ≤ f pI ≤ 0.39 (prior report). Farther from the ODT, within these composition ranges, the HPL phase occurs. We did not find the ordered bicontinuous double diamond (OBDD) morphology at any composition or temperature studied, and the overall phase diagram is qualitatively different from those reported previously for PI-PS block copolymers.

Evaluation and Management of Adult Hypoglycemic Disorders: An Endocrine Society Clinical Practice Guideline

Abstract: Objective: The aim is to provide guidelines for the evaluation and management of adults with hypoglycemic disorders, including those with diabetes mellitus. Evidence: Using the recommendations of the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system, the quality of evidence is graded very low (⊕○○○), low (⊕⊕○○), moderate (⊕⊕⊕○), or high (⊕⊕⊕⊕). Conclusions: We recommend evaluation and management of hypoglycemia only in patients in whom Whipple’s triad—symptoms, signs, or both consistent with hypoglycemia, a low plasma glucose concentration, and resolution of those symptoms or signs after the plasma glucose concentration is raised—is documented. In patients with hypoglycemia without diabetes mellitus, we recommend the following strategy. First, pursue clinical clues to potential hypoglycemic etiologies—drugs, critical illnesses, hormone deficiencies, nonislet cell tumors. In the absence of these causes, the differential diagnosis narrows to accidental, surreptitious, or even...

Key issues in information systems management

Abstract: The results from a five-part Delphi survey of chief IS executives and corporate general managers indicate the most critical information systems management issues and consensus on their importance. The research project is the second in a series of such studies conducted by the Society for Information Management and the MIS Research Center at the University of Minnesota. The research confirmed the expected in some areas and revealed surprises in other areas. While strategic planning continued to top all issue sin importance, many changes have occurred since 1983. Three new issues have joined the top ten issues in importance. Also, the rank order of several issues in the top ten has shifted. Survey results are discussed in terms of the differing views of IS executives and corporate general managers. A review of how these views have changed over time is also presented. A number of conclusions are drawn about managing information systems and about the changing nature of the IS executive's job.

Gibberellin signaling: biosynthesis, catabolism, and response pathways.

Abstract: The power of molecular genetics has dramatically advanced our understanding of all aspects of gibberellin (GA) signaling. Many genes encoding GA response pathway components have been identified using Arabidopsis and cereal mutants, and more elaborate genetic screens are producing additional mutants

BMD at Multiple Sites and Risk of Fracture of Multiple Types: Long-Term Results From the Study of Osteoporotic Fractures

Abstract: In a large cohort of U.S. women aged 65 and older, we report the relationships of BMD measured at several sites, and subsequent fracture risk at multiple sites over >8 years of follow-up. Although we found almost all fracture types to be related to low BMD, the overall proportion of fractures attributable to low BMD is modest. Introduction: Although several studies have reported the relationship between bone mineral density (BMD) and subsequent fracture risk, most have been limited by short follow-up time, BMD measures at only one or two sites, or availability of data for only select fracture types. Materials and Methods: In the multicenter Study of Osteoporotic Fractures (SOF), we studied the relationship of several different BMD measures to fracture risk of multiple types in 9704 non-black women aged 65 and older. We previously reported on the relationship of peripheral BMD measures to risk of several types of fracture during an average 2.2-year follow-up period. In this expanded analysis, we present results of the relationship of both peripheral and central BMD measures and fractures of multiple types during 10.4 and 8.5 years of follow-up, respectively. We also report population attributable risk (PAR) estimates for osteoporosis and risk of several types of fracture. Results: Our results show that almost all types of fractures have an increased incidence in women with low BMD. However, hip BMD is somewhat more strongly related to most of the fracture types studied than spine or peripheral BMD measures. Nonetheless, the proportion of fractures attributable to osteoporosis (based on a standard definition of osteoporosis) is modest, ranging from <10% to 44% based on the most commonly used definition of osteoporosis (BMD T-score < −2.5). Conclusion: Finding effective prevention strategies for fractures in older women will require additional interventions beside preventions for bone loss, such as prevention of falls and other fracture risk factors.