University of Minnesota

About: University of Minnesota is a education organization based out in Minneapolis, Minnesota, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 117432 authors who have published 257986 publications receiving 11944239 citations. The organization is also known as: University of Minnesota, Twin Cities & University of Minnesota-Twin Cities.

Selecting the right interestingness measure for association patterns

Abstract: Many techniques for association rule mining and feature selection require a suitable metric to capture the dependencies among variables in a data set. For example, metrics such as support, confidence, lift, correlation, and collective strength are often used to determine the interestingness of association patterns. However, many such measures provide conflicting information about the interestingness of a pattern, and the best metric to use for a given application domain is rarely known. In this paper, we present an overview of various measures proposed in the statistics, machine learning and data mining literature. We describe several key properties one should examine in order to select the right measure for a given application domain. A comparative study of these properties is made using twenty one of the existing measures. We show that each measure has different properties which make them useful for some application domains, but not for others. We also present two scenarios in which most of the existing measures agree with each other, namely, support-based pruning and table standardization. Finally, we present an algorithm to select a small set of tables such that an expert can select a desirable measure by looking at just this small set of tables.

Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection

Abstract: Methods. This nested case-control study included 74 subjects who died, 120 of whom developed cardiovascular disease and 81 of whom developed AIDS during the Strategies for Management of Anti-Retroviral Therapy (SMART) study with matched control subjects. Intestinal fatty acid binding protein (I-FABP), lipopolysaccharide (LPS), soluble CD14 (sCD14), endotoxin core antibody (EndoCAb), and 16S ribosomal DNA (rDNA) were measured in baseline plasma samples. Results. Subjects with the highest quartile of sCD14 levels had a 6-fold higher risk of death than did those in the lowest quartile (95% confidence interval, 2.2‐16.1; P,.001), with minimal change after adjustment for inflammatory markers, CD4 1 T cell count, and HIV RNA level. No other marker was significantly associated with clinical outcomes. I-FABP, LPS, and sCD14 were increased and EndoCAb was decreased in study subjects, compared with healthy volunteers. sCD14 level correlated with levels of IL-6, C-reactive protein, serum amyloid A and D-dimer. Conclusions. sCD14, a marker of monocyte response to LPS, is an independent predictor of mortality in HIV infection. Therapeutic attenuation of innate immune activation may improve survival in patients with HIV infection.