Institution
University of Minnesota
Education•Minneapolis, Minnesota, United States•
About: University of Minnesota is a education organization based out in Minneapolis, Minnesota, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 117432 authors who have published 257986 publications receiving 11944239 citations. The organization is also known as: University of Minnesota, Twin Cities & University of Minnesota-Twin Cities.
Topics: Population, Transplantation, Poison control, Health care, Gene
Papers published on a yearly basis
Papers
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TL;DR: In industrial markets, buyers and sellers are increasingly replacing conventional "arm's length" arrangements with "alliances" involving closer ties as discussed by the authors, and the authors of this paper have developed a new approach to deal with this trend.
Abstract: Recent trends in industrial markets indicate that buyers and sellers are increasingly supplanting conventional “arm's length” arrangements with “alliances” involving closer ties. The authors develo...
2,131 citations
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Clinical Trial Service Unit1, University College London2, North Bristol NHS Trust3, University of Würzburg4, The George Institute for Global Health5, Children's Hospital at Westmead6, Peking Union Medical College7, Sultanah Aminah Hospital8, University of British Columbia9, National Institutes of Health10, Brigham and Women's Hospital11, University of Minnesota12, University of Otago13, University of Picardie Jules Verne14, University of Copenhagen15, Chiang Mai University16, Oslo University Hospital17, Charles University in Prague18, Medical University of Silesia19, Utrecht University20, University Medical Center Groningen21, University of Helsinki22, John Radcliffe Hospital23
TL;DR: Reduction of LDL cholesterol with simvastatin 20 mg plus ezetimibe 10 mg daily safely reduced the incidence of major atherosclerotic events in a wide range of patients with advanced chronic kidney disease.
2,123 citations
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TL;DR: This annotated reference sequence of wheat is a resource that can now drive disruptive innovation in wheat improvement, as this community resource establishes the foundation for accelerating wheat research and application through improved understanding of wheat biology and genomics-assisted breeding.
Abstract: An annotated reference sequence representing the hexaploid bread wheat genome in 21 pseudomolecules has been analyzed to identify the distribution and genomic context of coding and noncoding elements across the A, B, and D subgenomes. With an estimated coverage of 94% of the genome and containing 107,891 high-confidence gene models, this assembly enabled the discovery of tissue- and developmental stage-related coexpression networks by providing a transcriptome atlas representing major stages of wheat development. Dynamics of complex gene families involved in environmental adaptation and end-use quality were revealed at subgenome resolution and contextualized to known agronomic single-gene or quantitative trait loci. This community resource establishes the foundation for accelerating wheat research and application through improved understanding of wheat biology and genomics-assisted breeding.
2,118 citations
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TL;DR: The data of high precision show that the relationship between serum cholesterol and CHD is not a threshold one, with increased risk confined to the two highest quintiles, but rather is a continuously graded one that powerfully affects risk for the great majority of middle-aged American men.
Abstract: The 356 222 men aged 35 to 57 years, who were free of a history of hospitalization for myocardial infarction, screened by the Multiple Risk Factor Intervention Trial (MRFIT) in its recruitment effort, constitute the largest cohort with standardized serum cholesterol measurements and long-term mortality follow-up. For each five-year age group, the relationship between serum cholesterol and coronary heart disease (CHD) death rate was continuous, gradecf, and strong. For the entire group aged 35 to 57 years at entry, the age-adjusted risks of CHD death in cholesterol quintiles 2 through 5 (182 to 202, 203 to 220, 221 to 244, and ≥245 mg/dL [4.71 to 5.22, 5.25 to 5.69, 5.72 to 6.31, and ≥6.34 mmol/L]) relative to the lowest quintile were 1.29, 1.73, 2.21, and 3.42. Of all CHD deaths, 46% were estimated to be excess deaths attributable to serum cholesterol levels 180 mg/dL or greater (≥4.65 mmol/L), with almost half the excess deaths in serum cholesterol quintiles 2 through 4. The pattern of a continuous, graded, strong relationship between serum cholesterol and six-year age-adjusted CHD death rate prevailed for nonhypertensive nonsmokers, nonhypertensive smokers, hypertensive nonsmokers, and hypertensive smokers. These data of high precision show that the relationship between serum cholesterol and CHD is not a threshold one, with increased risk confined to the two highest quintiles, but rather is a continuously graded one that powerfully affects risk for the great majority of middle-aged American men. (JAMA1986;256:2823-2828)
2,113 citations
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TL;DR: Chameleon's key feature is that it accounts for both interconnectivity and closeness in identifying the most similar pair of clusters, which is important for dealing with highly variable clusters.
Abstract: Clustering is a discovery process in data mining. It groups a set of data in a way that maximizes the similarity within clusters and minimizes the similarity between two different clusters. Many advanced algorithms have difficulty dealing with highly variable clusters that do not follow a preconceived model. By basing its selections on both interconnectivity and closeness, the Chameleon algorithm yields accurate results for these highly variable clusters. Existing algorithms use a static model of the clusters and do not use information about the nature of individual clusters as they are merged. Furthermore, one set of schemes (the CURE algorithm and related schemes) ignores the information about the aggregate interconnectivity of items in two clusters. Another set of schemes (the Rock algorithm, group averaging method, and related schemes) ignores information about the closeness of two clusters as defined by the similarity of the closest items across two clusters. By considering either interconnectivity or closeness only, these algorithms can select and merge the wrong pair of clusters. Chameleon's key feature is that it accounts for both interconnectivity and closeness in identifying the most similar pair of clusters. Chameleon finds the clusters in the data set by using a two-phase algorithm. During the first phase, Chameleon uses a graph partitioning algorithm to cluster the data items into several relatively small subclusters. During the second phase, it uses an algorithm to find the genuine clusters by repeatedly combining these subclusters.
2,111 citations
Authors
Showing all 118112 results
Name | H-index | Papers | Citations |
---|---|---|---|
Walter C. Willett | 334 | 2399 | 413322 |
David J. Hunter | 213 | 1836 | 207050 |
David Miller | 203 | 2573 | 204840 |
Mark I. McCarthy | 200 | 1028 | 187898 |
Dennis W. Dickson | 191 | 1243 | 148488 |
David H. Weinberg | 183 | 700 | 171424 |
Eric Boerwinkle | 183 | 1321 | 170971 |
John C. Morris | 183 | 1441 | 168413 |
Aaron R. Folsom | 181 | 1118 | 134044 |
H. S. Chen | 179 | 2401 | 178529 |
Jie Zhang | 178 | 4857 | 221720 |
Jasvinder A. Singh | 176 | 2382 | 223370 |
Feng Zhang | 172 | 1278 | 181865 |
Gang Chen | 167 | 3372 | 149819 |
Hongfang Liu | 166 | 2356 | 156290 |