University of South Florida

About: University of South Florida is a education organization based out in Tampa, Florida, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 34231 authors who have published 72644 publications receiving 2538044 citations. The organization is also known as: USF.

A Survey of Intrusion Detection Systems in Wireless Sensor Networks

Abstract: Wireless Sensor Networking is one of the most promising technologies that have applications ranging from health care to tactical military. Although Wireless Sensor Networks (WSNs) have appealing features (e.g., low installation cost, unattended network operation), due to the lack of a physical line of defense (i.e., there are no gateways or switches to monitor the information flow), the security of such networks is a big concern, especially for the applications where confidentiality has prime importance. Therefore, in order to operate WSNs in a secure way, any kind of intrusions should be detected before attackers can harm the network (i.e., sensor nodes) and/or information destination (i.e., data sink or base station). In this article, a survey of the state-of-the-art in Intrusion Detection Systems (IDSs) that are proposed for WSNs is presented. Firstly, detailed information about IDSs is provided. Secondly, a brief survey of IDSs proposed for Mobile Ad-Hoc Networks (MANETs) is presented and applicability of those systems to WSNs are discussed. Thirdly, IDSs proposed for WSNs are presented. This is followed by the analysis and comparison of each scheme along with their advantages and disadvantages. Finally, guidelines on IDSs that are potentially applicable to WSNs are provided. Our survey is concluded by highlighting open research issues in the field.

Construction of a Job in General scale: A comparison of global, composite, and specific measures.

Abstract: We describe the construction of a Job in General (JIG) scale, a global scale to accompany the facetscales of the Job Descriptive Index. We applied both traditional and item response theory proceduresfor item analysis to data from three large heterogeneous samples (N = 1,149, 3,566, and 4,490).Alpha was .91 and above for the resulting 18-item scale in successive samples. Convergent and dis-criminant validity and differential response to treatments were demonstrated. Global scales are con-trasted with composite and with facet scales in psychological measurement. We show that globalscales are not equivalent to summated facet scales. Both facet and global scales were useful in anotherorganization (N = 648). Some principles are suggested for choosing specific (facet), composite, orglobal measures for practical and theoretical problems. The correlations between global and facetscales suggest that work may be the most important facet in relation to general job satisfaction.

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

Abstract: Immunosuppression of tumour-infiltrating lymphocytes (TIL) is a common feature of advanced cancer, but its biological basis has remained obscure. We demonstrate here a molecular link between epithelial-to-mesenchymal transition (EMT) and CD8(+) TIL immunosuppression, two key drivers of cancer progression. We show that microRNA-200 (miR-200), a cell-autonomous suppressor of EMT and metastasis, targets PD-L1. Moreover, ZEB1, an EMT activator and transcriptional repressor of miR-200, relieves miR-200 repression of PD-L1 on tumour cells, leading to CD8(+) T-cell immunosuppression and metastasis. These findings are supported by robust correlations between the EMT score, miR-200 levels and PD-L1 expression in multiple human lung cancer datasets. In addition to revealing a link between EMT and T-cell dysfunction, these findings also show that ZEB1 promotes metastasis through a heretofore unappreciated cell non-autonomous mechanism, and suggest that subgroups of patients in whom malignant progression is driven by EMT activators may respond to treatment with PD-L1 antagonists.

Polymorphs, Salts, and Cocrystals: What’s in a Name?

Abstract: The December 2011 release of a draft United States Food and Drug Administration (FDA) guidance concerning regulatory classification of pharmaceutical cocrystals of active pharmaceutical ingredients (APIs) addressed two matters of topical interest to the crystal engineering and pharmaceutical science communities: (1) a proposed definition of cocrystals; (2) a proposed classification of pharmaceutical cocrystals as dissociable “API-excipient” molecular complexes. The Indo–U.S. Bilateral Meeting sponsored by the Indo–U.S. Science and Technology Forum titled The Evolving Role of Solid State Chemistry in Pharmaceutical Science was held in Manesar near Delhi, India, from February 2–4, 2012. A session of the meeting was devoted to discussion of the FDA guidance draft. The debate generated strong consensus on the need to define cocrystals more broadly and to classify them like salts. It was also concluded that the diversity of API crystal forms makes it difficult to classify solid forms into three categories that...