Showing papers by "University of South Florida published in 2007"
TL;DR: In this paper, the authors examined how the field of mixed methods currently is being defined and discussed the criteria of demarcation in mixed methods research, and concluded that mixed methods are one of the three major research paradigms.
Abstract: The purpose of this article is to examine how the field of mixed methods currently is being defined. The authors asked many of the current leaders in mixed methods research how they define mixed methods research. The authors provide the leaders' definitions and discuss the content found as they searched for the criteria of demarcation. The authors provide a current answer to the question, What is mixed methods research? They also briefly summarize the recent history of mixed methods and list several issues that need additional work as the field continues to advance. They argue that mixed methods research is one of the three major “research paradigms” (quantitative research, qualitative research, and mixed methods research). The authors hope this article will contribute to the ongoing dialogue about how mixed methods research is defined and conceptualized by its practitioners.
6,049 citations
TL;DR: The motivation for this project, the methods used to collect the data, and the search engine that affords access to the behavioral measures and descriptive lexical statistics for these stimuli are described.
Abstract: The English Lexicon Project is a multiuniversity effort to provide a standardized behavioral and descriptive data set for 40,481 words and 40,481 nonwords. It is available via the Internet at elexicon.wustl.edu. Data from 816 participants across six universities were collected in a lexical decision task (approximately 3400 responses per participant), and data from 444 participants were collected in a speeded naming task (approximately 2500 responses per participant). The present paper describes the motivation for this project, the methods used to collect the data, and the search engine that affords access to the behavioral measures and descriptive lexical statistics for these stimuli.
2,164 citations
Journal Article•
TL;DR: The recognition of these three cycles in a research project clearly positions and differentiates design science from other research paradigms and concludes with a claim to the pragmatic nature of design science.
Abstract: As a commentary to Juhani Iivari's insightful essay, I briefly analyze design science research as an embodiment of three closely related cycles of activities. The Relevance Cycle inputs requirements from the contextual envi- ronment into the research and introduces the research artifacts into environ- mental field testing. The Rigor Cycle provides grounding theories and methods along with domain experience and expertise from the foundations knowledge base into the research and adds the new knowledge generated by the research to the growing knowledge base. The central Design Cycle sup- ports a tighter loop of research activity for the construction and evaluation of design artifacts and processes. The recognition of these three cycles in a research project clearly positions and differentiates design science from other research paradigms. The commentary concludes with a claim to the pragmatic nature of design science.
1,641 citations
TL;DR: In this article, the authors argue that research on the business case for corporate social responsibility must account for the path-dependent nature of firm-stakeholder relations, and develop the construct of stakeholder influence capacity to fill this void.
Abstract: I argue that research on the business case for corporate social responsibility must account for the path-dependent nature of firm-stakeholder relations, and I develop the construct of stakeholder influence capacity to fill this void. This construct helps explain why the effects of corporate social responsibility on corporate financial performance vary across firms and time. I develop a set of propositions to aid future research on the contingencies that produce variable financial returns to investment in corporate social responsibility.
1,437 citations
TL;DR: Using a comprehensive sample of nearly 7,000 firms from 1990 to 2004, this paper examined corporate board structure, its trends, and its determinants, finding that firms structure their boards in response to the costs and benefits of the board's monitoring and advising roles.
Abstract: Using a comprehensive sample of nearly 7,000 firms from 1990 to 2004, this paper examines corporate board structure, its trends, and its determinants We study how board structure has evolved over time and, more importantly, we compare board structure across small and large firms in ways suggested by recent theoretical work Overall, our evidence suggests that firms structure their boards in response to the costs and benefits of the board's monitoring and advising roles Our models explain as much as 45% of the observed variation in board structure Further, small and large firms have dramatically different board structures For example, board size was falling in the 1990s for large firms, a trend that reversed at the time of mandated reforms, while board size was relatively flat over the 1990s for small and medium-sized firms
1,415 citations
TL;DR: In this article, the authors focus on relational ethics in research with intimate others, and examine auto-ethnographic narratives in which researchers include intimate others in stories focusing on their own experience.
Abstract: This article focuses on relational ethics in research with intimate others. Relational ethics requires researchers to act from our hearts and minds, acknowledge our interpersonal bonds to others, and take responsibility for actions and their consequences. Calling on her own research studies, the author examines relational ethics in ethnographies in which researchers are friends with or become friends with participants over the course of their projects. Then she examines autoethnographic narratives in which researchers include intimate others in stories focusing on their own experience. Considering ethical responsibilities to identifiable others, she discusses writing about those who are alive and those who have died. She then reflects on the ways co-constructed autoethnographies circumvent some of the ethical issues in traditional qualitative studies on unfamiliar others, yet avoid some of the ethical concerns in writing about intimate others. The last section presents advice for those who long to write a...
1,079 citations
Nova Southeastern University1, University of Colorado Denver2, University of South Florida3, Yale University4, University of Texas Southwestern Medical Center5, Pennsylvania State University6, University of California, Los Angeles7, University of Washington8, Johns Hopkins University9, Duke University10, Northwestern University11
TL;DR: These parameters were developed by the Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma & Immunology (AAAAI); the American Col- lege of Allergen,Asthma & immunology (ACAAI); and the Joint Council of All allergy, asthma, and Immunology.
Abstract: These parameters were developed by the Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma & Immunology (AAAAI); the American Col- lege of Allergy, Asthma & Immunology (ACAAI); and the Joint Council of Allergy, Asthma & Immunology. The American Academy of Allergy, Asthma & Immunology and the American College of Allergy, Asthma & Immunology have jointly accepted responsibility for establishing ''Allergen immunotherapy: A practice parameter third update.'' This is a complete and com- prehensive document at the current time. The medical environ- ment is a changing environment, and not all recommendations will be appropriate for all patients. Because this document incorporated the efforts of many participants, no single individ- ual, including those who served on the Joint Task Force, is authorizedtoprovideanofficial AAAAIorACAAIinterpretation ofthesepracticeparameters.Anyrequestforinformationaboutor an interpretation of these practice parameters by the AAAAI or the ACAAI should be directed to the Executive Offices of the AAAAI, the ACAAI, and the Joint Council of Allergy, Asthma & Immunology. These parameters are not designed for use by pharmaceutical companies in drug promotion. A current list of published practice parameters of the Joint Task Force on Practice ParametersforAllergyandImmunologycanbefoundinTableE1 in this article's Online Repository at www.jacionline.org. Disclosure ofpotentialconflictofinterest:L.Coxisaconsultant forGenentech/Novartis, Hollister-Stier, and Stallergenes; is a speaker for Novartis; has received research support from Stallergenes; is on the Board of Directors for the American Board of Allergy and Immunology; and is on the US Food and Drug Administration (FDA)'s Allergenic Product Advisory Committee. H. Nelson is a consultant for Merck and Planet Biopharmaceuticals, is a Data and Safety Monitoring Board member of DBV Technologies, and has received research support from ALK-AbellM. Nelson has re- ceivedresearchsupportfromtheDepartmentofDefense,isaspeakerfortheAmerican College of Allergy, Asthma & Immunology (ACAAI), and is a member of the FDA's AdvisoryCommitteeonAllergicProducts.R.Weberisonthespeakers'bureauforAs- traZeneca and Genentech, has received research support from Novartis and Glaxo- SmithKline, and is Committee Chair of the ACAAI. D. I. Bernstein is a consultant and on the advisory board for ALK America, is on the advisory board for Merck, and has received research support from Merck and Schering-Plough. J. Blessing- Moore is a speaker for Merck-Schering/AstraZeneca, Novartis, TEVA, and Meda Alcon and has received research support from Meda. D. A. Khan is a speaker for As- traZeneca and Merck, has received research support from the Vanberg Family Foun- dation and the Sellars Family Foundation, is Conjoint Board Review Chair for the ACAAI,andisapastpresidentoftheTexasAllergy,AsthmaandImmunologySociety. D. M. Lang is a speaker and consultant for GlaxoSmithKline; is a speaker for Astra- Zeneca, Merck, TEVA, Sanofi-Aventis, and Genentech/Novartis; and has received re- search support from Genentech/Novartis. R. A. Nicklas is a fellow for the ACAAI. J. Oppenheimer is a consultant and has provided lectures for AstraZeneca, Merck, and GlaxoSmithKline; and has received research support from AstraZeneca, Merck, Glax- oSmithKline, and Genentech. J. M. Portnoy is a speaker for Phadia, Merck, and CSL Behring; hasreceived researchsupportfromtheUSDepartment ofHousingandUrban Development;andisa board memberof theACAAI board of regents.S.L. Spector has received research support from Genentech, GlaxoSmithKline, Schering-Plough, Aventis, Novartis, Pharmaxis, Boehringer Ingelheim, AstraZeneca, Johnson & John- son, Xyzal, Alcon, Centocor, Sepracor, UCB, Amgen, Capnia, and IVAX. S. Tilles isaspeakerforAlcon; isontheadvisoryboard forALK,Ista,Merck,andStallergenes; has received research support from Alcon, Amgen, Amphastar, Astellas, Boehringer Ingelheim,Ception,Genentech,Icagen, MAP Pharma, MEDA, Merck, Novartis, Rox- ane, and Sepracor; is Associate Editor of Allergy Watchand Annals of Allergy; and is a task force member for the Joint Task Force for Practice Parameters. D. Wallace is a speaker and advisor for Alcon, is a speaker for Merck and Sanofi-Aventis, and is President-Elect of the ACAAI. The rest of the authors have declared that they have no conflict of interest.
1,055 citations
TL;DR: In vivo models show that MDSCs directly disrupt the binding of specific peptide–major histocompatibility complex dimers to CD8-expressing T cells through nitration of tyrosines in a T-cell receptor (TCR)-CD8 complex, identifying a previously unknown mechanism of T- cell tolerance in cancer.
Abstract: Antigen-specific CD8+ T-cell tolerance, induced by myeloid-derived suppressor cells (MDSCs), is one of the main mechanisms of tumor escape. Using in vivo models, we show here that MDSCs directly disrupt the binding of specific peptide–major histocompatibility complex (pMHC) dimers to CD8-expressing T cells through nitration of tyrosines in a T-cell receptor (TCR)-CD8 complex. This process makes CD8-expressing T cells unable to bind pMHC and to respond to the specific peptide, although they retain their ability to respond to nonspecific stimulation. Nitration of TCR-CD8 is induced by MDSCs through hyperproduction of reactive oxygen species and peroxynitrite during direct cell-cell contact. Molecular modeling suggests specific sites of nitration that might affect the conformational flexibility of TCR-CD8 and its interaction with pMHC. These data identify a previously unknown mechanism of T-cell tolerance in cancer that is also pertinent to many pathological conditions associated with accumulation of MDSCs.
1,049 citations
1,044 citations
TL;DR: It is demonstrated that Bif-1 interacts with Beclin 1 through ultraviolet irradiation resistance-associated gene (UVRAG) and functions as a positive mediator of the class III PI(3) kinase (PI( 3)KC3) and observed that B if-1 ablation prolongs cell survival under starvation conditions.
Abstract: Autophagy is an evolutionarily conserved ‘self-eating’ process. Although the genes essential for autophagy (named Atg) have been identified in yeast, the molecular mechanism of how Atg proteins control autophagosome formation in mammalian cells remains to be elucidated. Here, we demonstrate that Bif-1 (also known as Endophilin B1) interacts with Beclin 1 through ultraviolet irradiation resistance-associated gene (UVRAG) and functions as a positive mediator of the class III PI(3) kinase (PI(3)KC3). In response to nutrient deprivation, Bif-1 localizes to autophagosomes where it colocalizes with Atg5, as well as microtubule-associated protein light chain 3 (LC3). Furthermore, loss of Bif-1 suppresses autophagosome formation. Although the SH3 domain of Bif-1 is sufficient for binding to UVRAG, both the BAR and SH3 domains are required for Bif-1 to activate PI(3)KC3 and induce autophagosome formation. We also observed that Bif-1 ablation prolongs cell survival under starvation conditions. Moreover, knockout of Bif-1 significantly enhances the
870 citations
TL;DR: The Qualitative Legitimation Model as discussed by the authors attempts to integrate many of the types of validity identified by qualitative researchers, and describes 24 methods for assessing the truth value of qualitative research.
Abstract: Although the importance of validity has long been accepted among quantitative researchers, this concept has been an issue of contention among qualitative researchers. Thus, the first purpose of the present paper is to introduce the Qualitative Legitimation Model, which attempts to integrate many of the types of validity identified by qualitative researchers. The second purpose of this article is to describe 24 methods for assessing the truth value of qualitative research. Utilizing and documenting such techniques should prevent validity and qualitative research from being seen as an oxymoron.
TL;DR: A framework for making sampling and sample size considerations in interpretive research is provided for making sample sizes and sampling designs that are most compatible with their research purposes.
Abstract: The purpose of this paper is to emphasize the importance of sampling and sample size considerations in all qualitative research. Such considerations would help qualitative researchers to select sample sizes and sampling designs that are most compatible with their research purposes. First, we discuss the importance of sampling in qualitative research. Next, we outline 24 designs for selecting a sample in qualitative research. We then discuss the importance of selecting a sample size that yields data that have a realistic chance of reaching data saturation, theoretical saturation, or informational redundancy. Based on the literature, we then provide sample size guidelines for several qualitative research designs. As such, we provide a framework for making sampling and sample size considerations in interpretive research.
TL;DR: An update on the studies that address the domains of a geriatric assessment applied to the oncology patient, the results of the first studies evaluating the use of a CGA in developing interventions to improve the care of older adults with cancer, and future research directions are provided.
Abstract: Purpose During the last decade, oncologists and geriatricians have begun to work together to integrate the principles of geriatrics into oncology care. The increasing use of a comprehensive geriatric assessment (CGA) is one example of this effort. A CGA includes an evaluation of an older individual's functional status, comorbid medical conditions, cognition, nutritional status, psychological state, and social support; and a review of the patient's medications. This article discusses recent advances on the use of a CGA in older patients with cancer. Methods In this article, we provide an update on the studies that address the domains of a geriatric assessment applied to the oncology patient, review the results of the first studies evaluating the use of a CGA in developing interventions to improve the care of older adults with cancer, and discuss future research directions. Results The evidence from recent studies demonstrates that a CGA can predict morbidity and mortality in older patients with cancer. Acc...
TL;DR: In this article, the authors examined the nature of strategic communication, defined as the purposeful use of communication by an organization to fulfill its mission, and identified key aspects of communication.
Abstract: This article examines the nature of strategic communication, which is defined as the purposeful use of communication by an organization to fulfill its mission. Six relevant disciplines are involved in the development, implementation, and assessment of communications by organizations: management, marketing, public relations, technical communication, political communication, and information/social marketing campaigns. The nature of the term strategic is examined, and key aspects of communication are identified. This article is based, in part, on a panel discussion involving the journal's editors and international scholars at the International Communication Association in May 2005 in New York.
TL;DR: Systemic administration of FGF-21 reduced plasma glucose and triglycerides to near normal levels in genetically compromised diabetic rodents and led to significant improvements in lipoprotein profiles, including lowering of low-density lipop Protein cholesterol and raising of high-density Lipoprotein cholesterol.
Abstract: Fibroblast growth factor (FGF)-21 has been recently characterized as a potent metabolic regulator. Systemic administration of FGF-21 reduced plasma glucose and triglycerides to near normal levels in genetically compromised diabetic rodents. Importantly, these effects were durable and did not come at the expense of weight gain, hypoglycemia, or mitogenicity. To explore the therapeutic properties of FGF-21 in a nongenetically modified primate species, and thus demonstrate the potential for efficacy in humans, we evaluated its bioactivity in diabetic nonhuman primates. When administered daily for 6 wk to diabetic rhesus monkeys, FGF-21 caused a dramatic decline in fasting plasma glucose, fructosamine, triglycerides, insulin, and glucagon. Of significant importance in regard to safety, hypoglycemia was not observed at any point during the study. FGF-21 administration also led to significant improvements in lipoprotein profiles, including lowering of low-density lipoprotein cholesterol and raising of high-density lipoprotein cholesterol, beneficial changes in the circulating levels of several cardiovascular risk markers/factors, and the induction of a small but significant weight loss. These data support the development of FGF-21 for the treatment of diabetes and other metabolic diseases.
TL;DR: An overall estimate of the received-perceived support relationship is found using the Inventory of Socially Supportive Behaviors and any measure of perceived social support to find an average correlation of r = .35, p < .001.
Abstract: Social support is broad term encompassing a variety of constructs, including support perceptions (perceived support) and receipt of supportive behaviors (received support). Of these constructs, only perceived support has been regarded as consistently linked to health, and researchers have offered differing assessments of the strength of the received-perceived support relationship. An overall estimate of the received-perceived support relationship would clearly further the dialogue on the relationship between received and perceived support and thus assist in the theoretical development of the field. This study evaluated all available studies using the Inventory of Socially Supportive Behaviors (ISSB; Barrera, Sandler, & Ramsey, 1981, American Journal of Community Psychology, 9, 435–447) and any measure of perceived social support. Using effect sizes from 23 studies, we found an average correlation of r = .35, p < .001. Implications of this estimate for further development of models of social support as well as interventions to enhance social support are discussed.
TL;DR: It is concluded that a low-dose, dose-intensity schedule of decitabine optimizes epigenetic modulation and clinical responses in MDS.
University of Massachusetts Amherst1, University of Toledo2, Miami University3, Food and Drug Administration4, Yale University5, University of Louisville6, University of Western Ontario7, Taipei Medical University8, University of Rochester9, University of South Florida10, Eli Lilly and Company11, United States Department of Agriculture12, University of Düsseldorf13, Harvard University14, College of the Holy Cross15, University of Colorado Boulder16, Michigan State University17, Indiana University18, Jilin University19, University of Texas Health Science Center at San Antonio20, University of Louisiana at Monroe21, McMaster University22, RTI International23, University of Florida24, Kansas State University25, University of California, Irvine26, University of Michigan27, Aarhus University28, North Carolina State University29, Stanford University30, Lovelace Respiratory Research Institute31, University of Wyoming32, University of Tasmania33, Binghamton University34, New York Medical College35, National Institutes of Health36
TL;DR: This article offers a set of recommendations that scientists believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.
TL;DR: It is suggested that, in addition to its role in microtubule-dependent cell motility, HDAC6 influences actin-dependentCell motility by altering the acetylation status of cortactin, which, in turn, changes the F-actin binding activity of Cortactin.
TL;DR: Dealing with the long-term sequelae of CO poisoning requires clinical acumen and a high index of suspicion, combined with epidemiological data, clinical examination, analysis of ambient air CO and patient COHb levels, and neuropsychological testing.
TL;DR: This work identifies a GR-1+CD11b+ population whose numbers dramatically increase and remain elevated in the spleen, lymph nodes, and bone marrow during polymicrobial sepsis and contributes to sepsi-induced T cell suppression and preferential Th2 polarization.
Abstract: Polymicrobial sepsis alters the adaptive immune response and induces T cell suppression and Th2 immune polarization. We identify a GR-1(+)CD11b(+) population whose numbers dramatically increase and remain elevated in the spleen, lymph nodes, and bone marrow during polymicrobial sepsis. Phenotypically, these cells are heterogeneous, immature, predominantly myeloid progenitors that express interleukin 10 and several other cytokines and chemokines. Splenic GR-1(+) cells effectively suppress antigen-specific CD8(+) T cell interferon (IFN) gamma production but only modestly suppress antigen-specific and nonspecific CD4(+) T cell proliferation. GR-1(+) cell depletion in vivo prevents both the sepsis-induced augmentation of Th2 cell-dependent and depression of Th1 cell-dependent antibody production. Signaling through MyD88, but not Toll-like receptor 4, TIR domain-containing adaptor-inducing IFN-beta, or the IFN-alpha/beta receptor, is required for complete GR-1(+)CD11b(+) expansion. GR-1(+)CD11b(+) cells contribute to sepsis-induced T cell suppression and preferential Th2 polarization.
RMIT University1, University of South Florida2, University of Arkansas for Medical Sciences3, Rutgers University4, University of North Carolina at Chapel Hill5, University of Central Florida6, Skidmore College7, University of KwaZulu-Natal8, Florida State University9, University of Mary Hardin–Baylor10, Texas A&M University11, Baylor University12, Carroll University13, Nova Southeastern University14
TL;DR: Vast research supports the contention that individuals engaged in regular exercise training require more dietary protein than sedentary individuals, and supplemental protein in various forms are a practical way of ensuring adequate and quality protein intake for athletes.
Abstract: Position Statement
The following seven points related to the intake of protein for healthy, exercising individuals constitute the position stand of the Society. They have been approved by the Research Committee of the Society. 1) Vast research supports the contention that individuals engaged in regular exercise training require more dietary protein than sedentary individuals. 2) Protein intakes of 1.4 – 2.0 g/kg/day for physically active individuals is not only safe, but may improve the training adaptations to exercise training. 3) When part of a balanced, nutrient-dense diet, protein intakes at this level are not detrimental to kidney function or bone metabolism in healthy, active persons. 4) While it is possible for physically active individuals to obtain their daily protein requirements through a varied, regular diet, supplemental protein in various forms are a practical way of ensuring adequate and quality protein intake for athletes. 5) Different types and quality of protein can affect amino acid bioavailability following protein supplementation. The superiority of one protein type over another in terms of optimizing recovery and/or training adaptations remains to be convincingly demonstrated. 6) Appropriately timed protein intake is an important component of an overall exercise training program, essential for proper recovery, immune function, and the growth and maintenance of lean body mass. 7) Under certain circumstances, specific amino acid supplements, such as branched-chain amino acids (BCAA's), may improve exercise performance and recovery from exercise.
TL;DR: Techniques are described for efficiently estimating and compensating for the effects of a communication channel in a multi-carrier wireless communication system using the fact that the transmitted symbols are drawn from a finite-alphabet to efficiently estimate the propagation channel.
Abstract: Techniques are described for efficiently estimating and compensating for the effects of a communication channel in a multi-carrier wireless communication system. The techniques exploit the fact that the transmitted symbols are drawn from a finite-alphabet to efficiently estimate the propagation channel for multi-carrier communication systems, such systems using OFDM modulation. A transmitter transmits data through a communication channel according to the modulation format. A receiver includes a demodulator to demodulate the data and an estimator to estimate the channel based on the demodulated data. The channel estimator applies a power-law operation to the demodulated data to identify the channel. The techniques can be used in both blind and semi-blind modes of channel estimation.
TL;DR: It is reported that inhibition of Hsp90 led to decreases in p-tau levels independent of heat shock factor 1 (HSF1) activation, and this is the first demonstration to the authors' knowledge that blockade of the refolding pathway promotes p-Tau turnover through degradation.
Abstract: A primary pathologic component of Alzheimer's disease (AD) is the formation of neurofibrillary tangles composed of hyperphosphorylated tau (p-tau). Expediting the removal of these p-tau species may be a relevant therapeutic strategy. Here we report that inhibition of Hsp90 led to decreases in p-tau levels independent of heat shock factor 1 (HSF1) activation. A critical mediator of this mechanism was carboxy terminus of Hsp70-interacting protein (CHIP), a tau ubiquitin ligase. Cochaperones were also involved in Hsp90-mediated removal of p-tau, while those of the mature Hsp90 refolding complex prevented this effect. This is the first demonstration to our knowledge that blockade of the refolding pathway promotes p-tau turnover through degradation. We also show that peripheral administration of a novel Hsp90 inhibitor promoted selective decreases in p-tau species in a mouse model of tauopathy, further suggesting a central role for the Hsp90 complex in the pathogenesis of tauopathies. When taken in the context of known high-affinity Hsp90 complexes in affected regions of the AD brain, these data implicate a central role for Hsp90 in the development of AD and other tauopathies and may provide a rationale for the development of novel Hsp90-based therapeutic strategies.
TL;DR: Screening for lung cancer with low-dose CT may increase the rate of lung cancer diagnosis and treatment, but may not meaningfully reduce the risk of advanced lung cancer or death from lung cancer.
Abstract: ContextCurrent and former smokers are currently being screened for lung cancer with computed tomography (CT), although there are limited data on the effect screening has on lung cancer outcomes. Randomized controlled trials assessing CT screening are currently under way.ObjectiveTo assess whether screening may increase the frequency of lung cancer diagnosis and lung cancer resection or may reduce the risk of a diagnosis of advanced lung cancer or death from lung cancer.Design, Setting, and ParticipantsLongitudinal analysis of 3246 asymptomatic current or former smokers screened for lung cancer beginning in 1998 either at 1 of 2 academic medical centers in the United States or an academic medical center in Italy with follow-up for a median of 3.9 years.InterventionAnnual CT scans with comprehensive evaluation and treatment of detected nodules.Main Outcome MeasuresComparison of predicted with observed number of new lung cancer cases, lung cancer resections, advanced lung cancer cases, and deaths from lung cancer.ResultsThere were 144 individuals diagnosed with lung cancer compared with 44.5 expected cases (relative risk [RR], 3.2; 95% confidence interval [CI], 2.7-3.8; P<.001). There were 109 individuals who had a lung resection compared with 10.9 expected cases (RR, 10.0; 95% CI, 8.2-11.9; P<.001). There was no evidence of a decline in the number of diagnoses of advanced lung cancers (42 individuals compared with 33.4 expected cases) or deaths from lung cancer (38 deaths due to lung cancer observed and 38.8 expected; RR, 1.0; 95% CI, 0.7-1.3; P = .90).ConclusionsScreening for lung cancer with low-dose CT may increase the rate of lung cancer diagnosis and treatment, but may not meaningfully reduce the risk of advanced lung cancer or death from lung cancer. Until more conclusive data are available, asymptomatic individuals should not be screened outside of clinical research studies that have a reasonable likelihood of further clarifying the potential benefits and risks.
TL;DR: The results indicate that DGAT-mediated lipid accumulation in the liver is insufficient to cause insulin resistance and show that hepatic steatosis can occur independently of insulin resistance.
TL;DR: Three integrative theoretical framework elements-intention, perceived norms, and an environmental constraint variable, time home alone-emerged as stable predictors of sexual behavior outcomes in this body of literature.
TL;DR: Qualitative analysis suggested that across a number of studies the researchers made statistical generalizations that were not sufficiently warranted—culminating in interpretive inconsistency and contributing to crises of representation, legitimation, integration, and politics.
Abstract: A sequential design utilizing identical samples was used to classify mixed methods studies via a two-dimensional model, wherein sampling designs were grouped according to the time orientation of ea...
TL;DR: RRM1 and ERCC1 are determinants of survival after surgical treatment of early-stage, non-small-cell lung cancer.
Abstract: RRM1 expression correlated with the expression of ERCC1 (P<0.001) but not with the expression of PTEN (P = 0.37). The median disease-free survival exceeded 120 months in the group of patients with tumors that had high expression of RRM1 and was 54.5 months in the group with low expression of RRM1 (hazard ratio for disease progression or death in the high-expression group, 0.46; P = 0.004). The overall survival was more than 120 months for patients with tumors with high expression of RRM1 and 60.2 months for those with low expression of RRM1 (hazard ratio for death, 0.61; P = 0.02). Among these 187 patients, the survival advantage was limited to the 30% of patients with tumors that had a high expression of both RRM1 and ERCC1. Conclusions RRM1 and ERCC1 are determinants of survival after surgical treatment of earlystage, non–small-cell lung cancer.