University of Vienna

About: University of Vienna is a education organization based out in Vienna, Austria. It is known for research contribution in the topics: Population & Context (language use). The organization has 44686 authors who have published 95840 publications receiving 2907492 citations.

Brain iron and ferritin in Parkinson's and Alzheimer's diseases.

Abstract: Semiquantitative histological evaluation of brain iron and ferritin in Parkinson's (PD) and Alzheimer's disease (DAT) have been performed in paraffin sections of brain regions which included frontal cortex, hippocampus, basal ganglia and brain stem. The results indicate a significant selective increase of Fe3+ and ferritin in substantia nigra zona compacta but not in zona reticulata of Parkinsonian brains, confirming the biochemical estimation of iron. No such changes were observed in the same regions of DAT brains. The increase of iron is evident in astrocytes, macrophages, reactive microglia and non-pigmented neurons, and in damaged areas devoid of pigmented neurons. In substantia nigra of PD and PD/DAT, strong ferritin reactivity was also associated with proliferated microglia. A faint iron staining was seen occasionally in peripheral halo of Lewy bodies. By contrast, in DAT and PD/DAT, strong ferritin immunoreactivity was observed in and around senile plaques and neurofibrillary tangles. The interrelationship between selective increase of iron and ferritin in PD requires further investigation, because both changes could participate in the induction of oxidative stress and neuronal death, due to their ability to promote formation of oxygen radicals.

A wavelength-tunable fiber-coupled source of narrowband entangled photons.

Abstract: We demonstrate a wavelength-tunable, fiber-coupled source of polarization- entangled photons with extremely high spectral brightness and quality of entanglement. Using a 25 mm PPKTP crystal inside a polarization Sagnac interferometer we detect a spectral brightness of 273000 pairs (s mW nm)(-1), a factor of 28 better than comparable previous sources while state tomography showed the two-photon state to have a tangle of T = 0.987. This improvement was achieved by use of a long crystal, careful selection of focusing parameters and single-mode fiber coupling. We demonstrate that, due to the particular geometry of the setup, the signal and idler wavelengths can be tuned over a wide range without loss of entanglement.

Agent-based simulation of innovation diffusion: A review

Abstract: Mathematical modeling of innovation diffusion has attracted strong academic interest since the early 1960s. Traditional diffusion models have aimed at empirical generalizations and hence describe the spread of new products parsimoniously at the market level. More recently, agent-based modeling and simulation has increasingly been adopted since it operates on the individual level and, thus, can capture complex emergent phenomena highly relevant in diffusion research. Agent-based methods have been applied in this context both as intuition aids that facilitate theory-building and as tools to analyze real-world scenarios, support management decisions and obtain policy recommendations. This review addresses both streams of research. We critically examine the strengths and limitations of agent-based modeling in the context of innovation diffusion, discuss new insights agent-based models have provided, and outline promising opportunities for future research. The target audience of the paper includes both researchers in marketing interested in new findings from the agent-based modeling literature and researchers who intend to implement agent-based models for their own research endeavors. Accordingly, we also cover pivotal modeling aspects in depth (concerning, e.g., consumer adoption behavior and social influence) and outline existing models in sufficient detail to provide a proper entry point for researchers new to the field.

Stress signaling in yeast

Abstract: In the yeast Saccharomyces cerevisiae three positive transcriptional control elements are activated by stress conditions: heat shock elements (HSEs), stress response elements (STREs) and AP-1 responsive elements (AREs). HSEs bind heat shock transcription factor (HSF), which is activated by stress conditions causing accumulation of abnormal proteins. STREs mediate transcriptional activation by multiple stress conditions. They are controlled by high osmolarity via the HOG signal pathway, which comprises a MAP kinase module and a two-component system homologous to prokaryotic signal transducers. AREs bind the transcription factor Yap1p. The three types of control elements seem to have overlapping, but distinct functions. Some stress proteins encoded by HSE-regulated genes are necessary for growth of yeast under moderate stress, products of STRE-activated genes appear to be important for survival under severe stress and ARE-controlled genes may mainly function during oxidative stress and in the response to toxic conditions, such as caused by heavy metal ions.

Perspective volume rendering of CT and MR images: applications for endoscopic imaging.

Abstract: PURPOSE: To use perspective volume rendering (PVR) of computed tomographic (CT) and magnetic resonance (MR) imaging data sets to simulate endoscopic views of human organ systems. MATERIALS AND METHODS: Perspective views of helical CT and MR images were reconstructed from the data, and tissues were classified by assigning color and opacity based on their CT attenuation or MR signal intensity. "Flight paths" were constructed through anatomic regions by defining key views along a spline path. Twelve movies of the thoracic aorta (n=3), tracheobronchial tree (n=4), colon (n=3), paranasal sinuses (n=1), and shoulder joint (n=1) were generated to display images along the flight path. All abnormal results were confirmed at surgery. RESULTS: PVR fly-through enabled evaluation of the full range of tissue densities, signal intensities, and their three-dimensional spatial relationships. CONCLUSION: PVR is a novel way to present volumetric data and may enable noninvasive diagnostic endoscopy and provide an alternate m...