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Institution

University of Vienna

EducationVienna, Austria
About: University of Vienna is a education organization based out in Vienna, Austria. It is known for research contribution in the topics: Population & Context (language use). The organization has 44686 authors who have published 95840 publications receiving 2907492 citations.


Papers
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Journal ArticleDOI
TL;DR: The view that resident human LC, like murine LC, represent immature precursors of lymphoid dendritic cells in skin-draining lymph nodes is supported.

382 citations

Journal ArticleDOI
TL;DR: A general Bell inequality is derived which is a sufficient and necessary condition for the correlation function for N particles to be describable in a local and realistic picture, for the case in which measurements on each particle can be chosen between two arbitrary dichotomic observables.
Abstract: We derive a single general Bell inequality which is a sufficient and necessary condition for the correlation function for N particles to be describable in a local and realistic picture, for the case in which measurements on each particle can be chosen between two arbitrary dichotomic observables. We also derive a necessary and sufficient condition for an arbitrary N-qubit mixed state to violate this inequality. This condition is a generalization and reformulation of the Horodecki family condition for two qubits.

381 citations

Journal ArticleDOI
TL;DR: The Coordinated Synoptic Investigation of NGC 2264 (CSI 2264) as discussed by the authors was a 30-day multi-wavelength photometric monitoring campaign on more than 1000 young star members using 16 telescopes.
Abstract: We present the Coordinated Synoptic Investigation of NGC 2264, a continuous 30 day multi-wavelength photometric monitoring campaign on more than 1000 young cluster members using 16 telescopes. The unprecedented combination of multi-wavelength, high-precision, high-cadence, and long-duration data opens a new window into the time domain behavior of young stellar objects. Here we provide an overview of the observations, focusing on results from Spitzer and CoRoT. The highlight of this work is detailed analysis of 162 classical T Tauri stars for which we can probe optical and mid-infrared flux variations to 1% amplitudes and sub-hour timescales. We present a morphological variability census and then use metrics of periodicity, stochasticity, and symmetry to statistically separate the light curves into seven distinct classes, which we suggest represent different physical processes and geometric effects. We provide distributions of the characteristic timescales and amplitudes and assess the fractional representation within each class. The largest category (>20%) are optical "dippers" with discrete fading events lasting ~1-5 days. The degree of correlation between the optical and infrared light curves is positive but weak; notably, the independently assigned optical and infrared morphology classes tend to be different for the same object. Assessment of flux variation behavior with respect to (circum)stellar properties reveals correlations of variability parameters with Hα emission and with effective temperature. Overall, our results point to multiple origins of young star variability, including circumstellar obscuration events, hot spots on the star and/or disk, accretion bursts, and rapid structural changes in the inner disk.

381 citations

Journal ArticleDOI
TL;DR: The authors make the case for a richer conception predicated on broader intellectual engagement and identify some preconditions for its practical fulfilment, and suggest that interdisciplinary dialogue should engender plural representations of Earth's present and future that are reflective of divergent human values and aspirations.
Abstract: Calls for more broad-based, integrated, useful knowledge now abound in the world of global environmental change science. They evidence many scientists' desire to help humanity confront the momentous biophysical implications of its own actions. But they also reveal a limited conception of social science and virtually ignore the humanities. They thereby endorse a stunted conception of 'human dimensions' at a time when the challenges posed by global environmental change are increasing in magnitude, scale and scope. Here, we make the case for a richer conception predicated on broader intellectual engagement and identify some preconditions for its practical fulfilment. Interdisciplinary dialogue, we suggest, should engender plural representations of Earth's present and future that are reflective of divergent human values and aspirations. In turn, this might insure publics and decision-makers against overly narrow conceptions of what is possible and desirable as they consider the profound questions raised by global environmental change.

381 citations

Journal ArticleDOI
TL;DR: In this article, the authors developed a methodologies which enable the detection of genotoxic effects in Hep G2 cells, which can identify mechanisms not detected in conventional in vitro systems such as induction of detoxifying enzymes, inactivation of endogenously formed DNA-reactive metabolites and intracellular inhibition of activating enzymes.
Abstract: The human hepatoma line (Hep G2) has retained the activities of various phase I and phase II enzymes which play a crucial role in the activation/detoxification of genotoxic procarcinogens and reflect the metabolism of such compounds in vivo better than experimental models with metabolically incompetent cells and exogenous activation mixtures. In the last years, methodologies have been developed which enable the detection of genotoxic effects in Hep G2 cells. Appropriate endpoints are the induction of 6-TGr mutants, of micronuclei and of comets (single cell gel electrophoresis assay). It has been demonstrated that various classes of environmental carcinogens such as nitrosamines, aflatoxins, aromatic and heterocyclic amines and polycyclic aromatic hydrocarbons can be detected in genotoxicity assays with Hep G2 cells. Furthermore, it has been shown that these assays can distinguish between structurally related carcinogens and non-carcinogens, and positive results have been obtained with rodent carcinogens (such as safrole and hexamethylphosphoramide) which give false negative results in conventional in vitro assays with rat liver homogenates. Hep G2 cells have also been used in antimutagenicity studies and can identify mechanisms not detected in conventional in vitro systems such as induction of detoxifying enzymes, inactivation of endogenously formed DNA-reactive metabolites and intracellular inhibition of activating enzymes.

381 citations


Authors

Showing all 45262 results

NameH-indexPapersCitations
Tomas Hökfelt158103395979
Wolfgang Wagner1562342123391
Hans Lassmann15572479933
Stanley J. Korsmeyer151316113691
Charles B. Nemeroff14997990426
Martin A. Nowak14859194394
Barton F. Haynes14491179014
Yi Yang143245692268
Peter Palese13252657882
Gérald Simonneau13058790006
Peter M. Elias12758149825
Erwin F. Wagner12537559688
Anton Zeilinger12563171013
Wolfgang Waltenberger12585475841
Michael Wagner12435154251
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20241
2023419
20221,085
20214,482
20204,534
20194,225