Institution
University of Vienna
Education•Vienna, Austria•
About: University of Vienna is a education organization based out in Vienna, Austria. It is known for research contribution in the topics: Population & Context (language use). The organization has 44686 authors who have published 95840 publications receiving 2907492 citations.
Topics: Population, Context (language use), Stars, Computer science, Galaxy
Papers published on a yearly basis
Papers
More filters
••
TL;DR: An overview is given of the cytotoxic effects of POMs with a special focus on POM‐based hybrid and nanocomposite structures and a proposed mode of actions and to identify molecular targets are provided.
Abstract: Polyoxometalates (POMs) are an emerging class of inorganic metal oxides, which over the last decades demonstrated promising biological activities by the virtue of their great diversity in structures and properties. They possess high potential for the inhibition of various tumor types; however, their unspecific interactions with biomolecules and toxicity impede their clinical usage. The current focus of the field of biologically active POMs lies on organically functionalized and POM-based nanocomposite structures as these hybrids show enhanced anticancer activity and significantly reduced toxicity towards normal cells in comparison to unmodified POMs. Although the antitumor activity of POMs is well documented, their mechanisms of action are still not well understood. In this Review, an overview is given of the cytotoxic effects of POMs with a special focus on POM-based hybrid and nanocomposite structures. Furthermore, we aim to provide proposed mode of actions and to identify molecular targets. POMs are expected to develop into the next generation of anticancer drugs that selectively target cancer cells while sparing healthy cells.
333 citations
••
TL;DR: The depletion of C. elegans W02A2.6p (called REC-8) by RNAi, induced univalent formation and splitting of chromosomes into sister chromatids at diakinesis, and the occurrence of DSBs in REC- 8-depleted meiocytes suggests that DSB formation does not depend on homologous synapsis.
Abstract: We have studied four Caenorhabditis elegans homologs of the Rad21/Scc1/Rec8 sister-chromatid cohesion protein family. Based on the RNAi phenotype and protein localization, it is concluded that one of them, W02A2.6p, is the likely worm ortholog of yeast Rec8p. The depletion of C. elegans W02A2.6p (called REC-8) by RNAi, induced univalent formation and splitting of chromosomes into sister chromatids at diakinesis. Chromosome synapsis at pachytene was defective, but primary homology recognition seemed unaffected, as a closer-than-random association of homologous fluorescence in situ hybridization (FISH) signals at leptotene/zygotene was observed. Depletion of REC-8 also induced chromosome fragmentation at diakinesis. We interpret these fragments as products of unrepaired meiotic double-stranded DNA breaks (DSBs), because fragmentation was suppressed in a spo-11 background. Thus, REC-8 seems to be required for successful repair of DSBs. The occurrence of DSBs in REC-8-depleted meiocytes suggests that DSB formation does not depend on homologous synapsis. Anti-REC-8 immunostaining decorated synaptonemal complexes (SCs) at pachytene and chromosomal axes in bivalents and univalents at diakinesis. Between metaphase I and metaphase II, REC-8 is partially lost from the chromosomes. The partial loss of REC-8 from chromosomes between metaphase I and metaphase II suggests that worm REC-8 might function similarly to yeast Rec8p. The loss of yeast Rec8p from chromosome arms at meiosis I and centromeres at meiosis II coordinates the disjunction of homologs and sister chromatids at the two meiotic divisions.
333 citations
••
University of Zurich1, Leiden University Medical Center2, National Institutes of Health3, University of Milan4, University of Graz5, Sapienza University of Rome6, Harvard University7, Charles University in Prague8, University of Vienna9, VU University Amsterdam10, University of Florence11, University of Copenhagen12, St Thomas' Hospital13, Humboldt University of Berlin14, University of Pittsburgh15
TL;DR: This article reviews the histological, phenotypical, and molecular genetic features of the various nosological entities included in the new WHO/EORTC classification of cutaneous lymphomas.
Abstract: The new WHO/EORTC classification for cutaneous lymphomas
comprises mature T-cell and natural killer (NK)-cell neoplasms,
mature B-cell neoplasms, and immature hematopoietic
malignancies. It reflects the unique features of
lymphoproliferative diseases of the skin, and at the same time
it is as compatible as possible with the concepts underlying
the WHO classification for nodal lymphomas and the EORTC
classification of cutaneous lymphomas. This article reviews the
histological, phenotypical, and molecular genetic features of
the various nosological entities included in this new
classification. These findings always have to be interpreted in
the context of the clinical features and biologic behavior
333 citations
••
333 citations
••
TL;DR: A demonstration of such controlled interactions by cavity cooling the center-of-mass motion of an optically trapped submicron particle paves the way for a light–matter interface that can enable room-temperature quantum experiments with mesoscopic mechanical systems.
Abstract: The coupling of a levitated submicron particle and an optical cavity field promises access to a unique parameter regime both for macroscopic quantum experiments and for high-precision force sensing. We report a demonstration of such controlled interactions by cavity cooling the center-of-mass motion of an optically trapped submicron particle. This paves the way for a light–matter interface that can enable room-temperature quantum experiments with mesoscopic mechanical systems.
333 citations
Authors
Showing all 45262 results
Name | H-index | Papers | Citations |
---|---|---|---|
Tomas Hökfelt | 158 | 1033 | 95979 |
Wolfgang Wagner | 156 | 2342 | 123391 |
Hans Lassmann | 155 | 724 | 79933 |
Stanley J. Korsmeyer | 151 | 316 | 113691 |
Charles B. Nemeroff | 149 | 979 | 90426 |
Martin A. Nowak | 148 | 591 | 94394 |
Barton F. Haynes | 144 | 911 | 79014 |
Yi Yang | 143 | 2456 | 92268 |
Peter Palese | 132 | 526 | 57882 |
Gérald Simonneau | 130 | 587 | 90006 |
Peter M. Elias | 127 | 581 | 49825 |
Erwin F. Wagner | 125 | 375 | 59688 |
Anton Zeilinger | 125 | 631 | 71013 |
Wolfgang Waltenberger | 125 | 854 | 75841 |
Michael Wagner | 124 | 351 | 54251 |