Vanderbilt University

About: Vanderbilt University is a education organization based out in Nashville, Tennessee, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 45066 authors who have published 106528 publications receiving 5435039 citations. The organization is also known as: Vandy.

Differentiating the pathologies of cerebral malaria by postmortem parasite counts.

Abstract: To study the pathogenesis of fatal cerebral malaria, we conducted autopsies in 31 children with this clinical diagnosis. We found that 23% of the children had actually died from other causes. The remaining patients had parasites sequestered in cerebral capillaries, and 75% of those had additional intra- and perivascular pathology. Retinopathy was the only clinical sign distinguishing malarial from nonmalarial coma. These data have implications for treating malaria patients, designing clinical trials and assessing malaria-specific disease associations.

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination.

Abstract: Immunogenicity and the mRNA-1273 SARS-CoV-2 Vaccine Thirty-four adults received two 100-μg injections of the mRNA-1273 SARS-CoV-2 vaccine, and serum anti–spike protein and neutralizing antibody tit...

Composition, process, and performance in self-managed groups: The role of personality.

Abstract: Using the five factor model with an emphasis on extraversion and conscientiousness, the authors investigated how personality is related to small group processes and outcomes. Graduate students (N = 289) assigned to 4- and 5-person teams in 61 groups engaged in a series of creative problem-solving tasks over a period of several weeks. Extraversion was associated with group processes and outcomes at both individual and group levels of analysis. At the individual level, extraverts were perceived by others as having greater effect than introverts on group outcomes. Covariance structure modeling suggested that extraverts induce these perceptions through the provision of both socioemotional and task-related inputs. At the group level, the proportion of relatively extraverted members was related curvilinearly to task focus and group performance. Contrary to expectations, Conscientiousness was unrelated to processes and outcomes at either the individual or group level.

Managing incidental findings in human subjects research: Analysis and recommendations

Abstract: Researchers, institutional review boards (IRBs), participants in human subjects research, and their families face an important but largely neglected problem — how should incidental findings (IFs) be managed in human subjects research. If researchers unexpectedly stumble upon information of potential health or reproductive significance, should they seek expert evaluation, contact the participant’s physician, tell the research participant, or respond with some combination? What should consent forms and the entire consent process say about how IFs will be handled in research? What should IRBs require?