Institution
Vanderbilt University
Education•Nashville, Tennessee, United States•
About: Vanderbilt University is a education organization based out in Nashville, Tennessee, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 45066 authors who have published 106528 publications receiving 5435039 citations. The organization is also known as: Vandy.
Topics: Population, Cancer, Receptor, Health care, Poison control
Papers published on a yearly basis
Papers
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TL;DR: Cytochrome P4503A (CYP3A) is importantly involved in the metabolism of many chemically diverse drugs administered to humans and makes it a major contributor to presystemic elimination following oral drug administration.
Abstract: Cytochrome P4503A (CYP3A) is importantly involved in the metabolism of many chemically diverse drugs administered to humans. Moreover, its localization in high amounts both in the small intestinal epithelium and liver makes it a major contributor to presystemic elimination following oral drug administration. Drug interactions involving enzyme inhibition or induction are common following the coadministration of two or more CYP3A substrates. Studies using in vitro preparations are useful in identifying such potential interactions and possibly permitting extrapolation of in vitro findings to the likely in vivo situation. Even if accurate quantitative predictions cannot be made, several classes of drugs can be expected to result in a drug interaction based on clinical experience. In many instances, the extent of such drug interactions is sufficiently pronounced to contraindicate the therapeutic use of the involved drugs.
811 citations
TL;DR: Infestation of Sirt3⁻/⁻ MEFs with lenti-MnSOD(K122-R) inhibited in vitro immortalization by an oncogene (Ras), inhibited IR-induced genomic instability, and decreased mitochondrial superoxide, suggesting acetylation directly regulates function.
811 citations
TL;DR: It was concluded that adenosine triphosphate was activating the enzyme in a fashion functionally distinct from its action as a phosphate donor, since the concentration of adenosines triph phosphate required for activation was much higher than that required for phosphorylation.
809 citations
TL;DR: The pharmacology and signaling of the nine known prostaglandin GPCRs are discussed and the specific roles that these receptors play in inflammation and immune modulation are highlighted.
808 citations
TL;DR: This paper performed causality tests between exports and growth for 37 developing countries and found that the results cast considerable doubt on the validity of the export promotion hypothesis, since these regressions provided no means of determining the direction of causality.
806 citations
Authors
Showing all 45403 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Walter C. Willett | 334 | 2399 | 413322 |
| Meir J. Stampfer | 277 | 1414 | 283776 |
| John Q. Trojanowski | 226 | 1467 | 213948 |
| Robert M. Califf | 196 | 1561 | 167961 |
| Matthew Meyerson | 194 | 553 | 243726 |
| Scott M. Grundy | 187 | 841 | 231821 |
| Tony Hunter | 175 | 593 | 124726 |
| David R. Jacobs | 165 | 1262 | 113892 |
| Donald E. Ingber | 164 | 610 | 100682 |
| L. Joseph Melton | 161 | 531 | 97861 |
| Ralph A. DeFronzo | 160 | 759 | 132993 |
| David W. Bates | 159 | 1239 | 116698 |
| Charles N. Serhan | 158 | 728 | 84810 |
| David Cella | 156 | 1258 | 106402 |
| Jay Hauser | 155 | 2145 | 132683 |