Institution
Virginia Commonwealth University
Education•Richmond, Virginia, United States•
About: Virginia Commonwealth University is a education organization based out in Richmond, Virginia, United States. It is known for research contribution in the topics: Population & Health care. The organization has 23822 authors who have published 49587 publications receiving 1787046 citations. The organization is also known as: VCU.
Topics: Population, Health care, Poison control, Medicine, Cancer
Papers published on a yearly basis
Papers
More filters
TL;DR: The shared genetic content of phage-related chromosomal islands is discussed, their life cycle and their ability to be transferred across large phylogenetic distances are discussed.
Abstract: The phage-related chromosomal islands (PRCIs) were first identified in Staphylococcus aureus as highly mobile, superantigen-encoding genetic elements known as the S. aureus pathogenicity islands (SaPIs). These elements are characterized by a specific set of phage-related functions that enable them to use the phage reproduction cycle for their own transduction and inhibit phage reproduction in the process. SaPIs produce many phage-like infectious particles; their streptococcal counterparts have a role in gene regulation but may not be infectious. These elements therefore represent phage satellites or parasites, not defective phages. In this Review, we discuss the shared genetic content of PRCIs, their life cycle and their ability to be transferred across large phylogenetic distances.
341 citations
TL;DR: The data suggests that older, heavier male patients with multiple comorbid conditions are at increased risk for leak and mortality of Roux en-Y gastric bypass and surgeons early in their learning curve should avoid these high-risk patients to reduce complications.
Abstract: Background: Intestinal leak is a potentially lethal complication of Roux en-Y gastric bypass (GBP). Identification of patients at high risk for leak may reduce complication rates of surgeons early in the procedure learning curve. Methods: A total of 3073 patients who underwent GBP were analyzed using univariate and multivariate logistic regression analyses of the following preoperative factors: hypertension (HTN), diabetes mellitus (DM), sleep apnea (SA), age, gender, weight, body mass index (BMI), and surgery type. Multivariate logistic regression analysis was performed for each procedure type. Results: There were 48 (1.5%) deaths. Independent risk factors for death included leak, weight, procedure type, and HTN. A total of 102 (3.2%) leaks were found. Independent factors for leak included age, male gender, SA, and procedure type. Conclusion: The data suggests that older, heavier male patients with multiple comorbid conditions are at increased risk for leak and mortality. Surgeons early in their learning curve should avoid these high-risk patients to reduce complications.
340 citations
Virginia Commonwealth University1, University of Calgary2, University of California, San Francisco3, University of Pittsburgh4, University of Virginia5, University of California, San Diego6, Northwestern University7, University of Michigan8, University of Alabama9, University of California, Davis10, Duke University11
TL;DR: Recommendations encompassing specific hematologic, renal, pulmonary, and endocrine complications of acute liver failure patients are provided, including their management during and after orthotopic liver transplantation.
Abstract: Objective:To provide a uniform platform from which to study acute liver failure, the U.S. Acute Liver Failure Study Group has sought to standardize the management of patients with acute liver failure within participating centers.Methods:In areas where consensus could not be reached because of diverg
340 citations
TL;DR: Therapy with canakinumab, an interleukin-1&bgr; inhibitor, is related to a dose-dependent reduction in HHF and the composite of HHF or heart failure–related mortality in a population of patients with prior myocardial infarction and elevations in high-sensitivity C-reactive protein.
Abstract: Background: Subclinical inflammation is associated with an increased risk of heart failure and with adverse prognosis in patients with established heart failure. Yet, treatments specifically direct...
340 citations
TL;DR: It is demonstrated that the neutrophil-derived MMP-8 is the predominant collagenase present in normal healing wounds and suggest that overexpression and activation of this collagenase may be involved in the pathogenesis of nonhealing chronic ulcers.
340 citations
Authors
Showing all 24085 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Ronald C. Kessler | 274 | 1332 | 328983 |
| Carlo M. Croce | 198 | 1135 | 189007 |
| Nicholas G. Martin | 192 | 1770 | 161952 |
| Michael Rutter | 188 | 676 | 151592 |
| Kenneth S. Kendler | 177 | 1327 | 142251 |
| Bernhard O. Palsson | 147 | 831 | 85051 |
| Thomas J. Smith | 140 | 1775 | 113919 |
| Ming T. Tsuang | 140 | 885 | 73865 |
| Patrick F. Sullivan | 133 | 594 | 92298 |
| Martin B. Keller | 131 | 541 | 65069 |
| Michael E. Thase | 131 | 923 | 75995 |
| Benjamin F. Cravatt | 131 | 666 | 61932 |
| Jian Zhou | 128 | 3007 | 91402 |
| Rena R. Wing | 128 | 649 | 67360 |
| Linda R. Watkins | 127 | 519 | 56454 |