Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets
Fan Jiang,Jianmin Yang,Yongtao Zhang,Mei Dong,Shuangxi Wang,Qunye Zhang,Fang Fang Liu,Kai Zhang,Cheng Zhang +8 more
Reads0
Chats0
TLDR
The ACE2-mediated catabolism of angiotensin II is likely to have a major role in cardiovascular protection, whereas the relevant functions and signalling mechanisms of actions induced by ang Elliotensin 1–7 have not been conclusively determined.Abstract:
The renin-angiotensin system (RAS) has pivotal roles in the regulation of normal physiology and the pathogenesis of cardiovascular disease. Angiotensin-converting enzyme (ACE) 2, and its product angiotensin 1-7, are thought to have counteracting effects against the adverse actions of other, better known and understood, members of the RAS. The physiological and pathological importance of ACE2 and angiotensin 1-7 in the cardiovascular system are not completely understood, but numerous experimental studies have indicated that these components have protective effects in the heart and blood vessels. Here, we provide an overview on the basic properties of ACE2 and angiotensin 1-7 and a summary of the evidence from experimental and clinical studies of various pathological conditions, such as hypertension, atherosclerosis, myocardial remodelling, heart failure, ischaemic stroke, and diabetes mellitus. ACE2-mediated catabolism of angiotensin II is likely to have a major role in cardiovascular protection, whereas the relevant functions and signalling mechanisms of actions induced by angiotensin 1-7 have not been conclusively determined. The ACE2-angiotensin 1-7 pathway, however, might provide a useful therapeutic target for the treatment of cardiovascular disease, especially in patients with overactive RAS.read more
Citations
More filters
Journal ArticleDOI
Risk factors associated with mortality among patients with COVID-19 in intensive care units in Lombardy, Italy
Giacomo Grasselli,Massimiliano Greco,Alberto Zanella,G. Albano,Massimo Antonelli,Giacomo Bellani,E. Bonanomi,Luca Cabrini,Eleonora Carlesso,Gian Paolo Castelli,S. Cattaneo,Danilo Cereda,S. Colombo,A. Coluccello,G. Crescini,A. Forastieri Molinari,Giuseppe Foti,Roberto Fumagalli,Giorgio Antonio Iotti,Thomas Langer,Nicola Latronico,F. L. Lorini,Francesco Mojoli,Giuseppe Natalini,C. M. Pessina,Vito Marco Ranieri,R. Rech,Luigia Scudeller,Antonio Rosano,Enrico Storti,B. T. Thompson,Marcello Tirani,Paola Villani,Antonio Pesenti,Maurizio Cecconi +34 more
TL;DR: The independent risk factors associated with mortality were evaluated with a multivariable Cox proportional hazards regression and infection with severe acute respiratory syndrome coronavirus 2 was confirmed by real-time reverse transcriptase-polymerase chain reaction assay of nasopharyngeal swabs.
Journal ArticleDOI
COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives.
TL;DR: The interaction between the viral spike protein and angiotensin-converting enzyme 2, which triggers entry of the virus into host cells, is likely to be involved in the cardiovascular manifestations of COVID-19.
Journal ArticleDOI
Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19.
Wentao Ni,Xiuwen Yang,Deqing Yang,Jing Bao,Ran Li,Yongjiu Xiao,Chang Hou,Haibin Wang,Jie Liu,Donghong Yang,Yu Xu,Zhaolong Cao,Zhancheng Gao +12 more
TL;DR: The SARS-CoV-2 spike glycoprotein, which binds to ACE2, is a potential target for developing specific drugs, antibodies, and vaccines and Restoring the balance between the RAS and ACE2/angiotensin-(1–7)/MAS may help attenuate organ injuries.
Journal ArticleDOI
COVID-19, ACE2, and the cardiovascular consequences.
TL;DR: The current perspective critically examines the evidence for ACE2 regulation by RAAS blockade and statins, the cardiovascular benefits of ACE2, and whether ACE2 blockade is a viable approach to attenuate COVID-19.
Book ChapterDOI
Endothelial Dysfunction and Hypertension.
Dildar Konukoglu,Hafize Uzun +1 more
TL;DR: The aim of this chapter is to explain endothelial dysfunction and the circulating molecules of endothelial cells as they become potential targets of therapeutic approach for hypertension, and the role of endothelium dysfunction in white coat hypertension has been discussed.
References
More filters
Journal ArticleDOI
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Zeneng Wang,Elizabeth Klipfell,Brian J. Bennett,Robert A. Koeth,Bruce S. Levison,Brandon DuGar,Ariel E. Feldstein,Earl B. Britt,Xiaoming Fu,Yoon-Mi Chung,Yuping Wu,Phil Schauer,Jonathan D. Smith,Hooman Allayee,W.H. Wilson Tang,Joseph A. DiDonato,Aldons J. Lusis,Stanley L. Hazen +17 more
TL;DR: Discovery of a relationship between gut-flora-dependent metabolism of dietary phosphatidylcholine and CVD pathogenesis provides opportunities for the development of new diagnostic tests and therapeutic approaches for atherosclerotic heart disease.
Journal ArticleDOI
A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9
Mary Donoghue,Frank Y. Hsieh,Elizabeth Baronas,Kevin Godbout,Michael Gosselin,Nancy E. Stagliano,Michael J. Donovan,Betty Woolf,Keith E. Robison,Raju Jeyaseelan,Roger E. Breitbart,Susan L. Acton +11 more
TL;DR: The organ- and cell-specific expression of ACE2 and its unique cleavage of key vasoactive peptides suggest an essential role for ACE2 in the local renin-angiotensin system of the heart and kidney.
Journal ArticleDOI
A Human Homolog of Angiotensin-converting Enzyme CLONING AND FUNCTIONAL EXPRESSION AS A CAPTOPRIL-INSENSITIVE CARBOXYPEPTIDASE
Sarah R. Tipnis,Nigel M. Hooper,Ralph J. Hyde,Eric H. Karran,Gary Christie,Anthony J. Turner +5 more
TL;DR: A novel human zinc metalloprotease that has considerable homology to human angiotensin-converting enzyme (ACE) (40% identity and 61% similarity) has been identified.
Journal ArticleDOI
Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.
Robson A.S. Santos,Ana Cristina Simões e Silva,Christine Maric,Denise M. R. Silva,Raquel Pillar Machado,Insa de Buhr,Silvia Heringer-Walther,Sérgio Veloso Brant Pinheiro,Myriam Teresa Lopes,Michael Bader,Elizabeth Pereira Mendes,Virgina Soares Lemos,Maria José Campagnole-Santos,Heinz-Peter Schultheiss,Robert C. Speth,Thomas Walther +15 more
TL;DR: Findings identify Mas as a functional receptor for Ang-(1–7) and provide a clear molecular basis for the physiological actions of this biologically active peptide.
Journal ArticleDOI
Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase.
Chad S Vickers,Paul Hales,Virendar K. Kaushik,Larry Dick,James M. Gavin,Jin Tang,Kevin Godbout,Thomas F. Parsons,Elizabeth Baronas,Frank Y. Hsieh,Susan L. Acton,Michael A. Patane,Andrew J. Nichols,Peter J. Tummino +13 more
TL;DR: The physiological role of ACE2 is elucidated, and its catalytic activity was characterized, and a consensus sequence of: Pro-X (1–3 residues)-Pro-Hydrophobic, where hydrolysis occurs between proline and the hydrophobic amino acid is revealed.
Related Papers (5)
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more