Bacterial Metabolism and Antibiotic Efficacy
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TLDR
This work aims to emphasize the close relationship between bacterial metabolism and antibiotic efficacy as well as propose areas of exploration to develop novel antibiotics that optimally exploit bacterial metabolic networks.About:
This article is published in Cell Metabolism.The article was published on 2019-08-06 and is currently open access. It has received 255 citations till now. The article focuses on the topics: Multidrug tolerance & Antibiotics.read more
Citations
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Journal ArticleDOI
A Deep Learning Approach to Antibiotic Discovery
Jonathan M. Stokes,Kevin Yang,Kyle Swanson,Wengong Jin,Andres Cubillos-Ruiz,Nina M. Donghia,Craig R. MacNair,Shawn French,Lindsey A. Carfrae,Zohar Bloom-Ackermann,Victoria M. Tran,Anush Chiappino-Pepe,Ahmed H. Badran,Ian W. Andrews,Ian W. Andrews,Ian W. Andrews,Emma J. Chory,George M. Church,Eric D. Brown,Tommi S. Jaakkola,Regina Barzilay,James J. Collins +21 more
TL;DR: A deep neural network capable of predicting molecules with antibacterial activity is trained and a molecule from the Drug Repurposing Hub-halicin- is discovered that is structurally divergent from conventional antibiotics and displays bactericidal activity against a wide phylogenetic spectrum of pathogens.
Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics
TL;DR: The efforts to understand why DinB (DNA polymerase IV) overproduction is cytotoxic to Escherichia coli led to the unexpected insight that oxidation of guanine to 8-oxo-guanine in the nucleotide pool underlies much of the cell death caused by both DinB overproduction and bactericidal antibiotics.
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Tolerance and resistance of microbial biofilms
TL;DR: The extent of the clinical problem, the mechanisms underlying the tolerance of bioFilms to antibiotics and to host responses, and the role of biofilms in the development of antimicrobial resistance mechanisms are presented.
Journal ArticleDOI
Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis.
Elio Rossi,Ruggero La Rosa,Jennifer A. Bartell,Rasmus L. Marvig,Janus A. J. Haagensen,Lea Mette Madsen Sommer,Søren Molin,Helle Krogh Johansen,Helle Krogh Johansen +8 more
TL;DR: The adaptive and evolutionary trajectories that lead to early diversification and late convergence, which enable P. aeruginosa to succeed in this niche are discussed, and it is pointed out how knowledge of these biological features may be used to guide diagnosis and therapy.
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Antibiotics in the clinical pipeline in October 2019
Mark S. Butler,David L. Paterson +1 more
TL;DR: There is still a significant gap in the pipeline for the development of new antibacterials with activity against β-metallolactamases, orally administered with broad spectrum G−ve activity, and new treatments for MDR Acinetobacter and gonorrhea.
References
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Journal ArticleDOI
Antiseptics and Disinfectants: Activity, Action, and Resistance
TL;DR: Known mechanisms of microbial resistance (both intrinsic and acquired) to biocides are reviewed, with emphasis on the clinical implications of these reports.
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Antibiotic resistance of bacterial biofilms
TL;DR: Biofilms can be prevented by early aggressive antibiotic prophylaxis or therapy and they can be treated by chronic suppressive therapy and a promising strategy may be the use of enzymes that can dissolve the biofilm matrix as well as quorum-sensing inhibitors that increase biofilm susceptibility to antibiotics.
Journal ArticleDOI
A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics
TL;DR: The results suggest that all three major classes of bactericidal drugs can be potentiated by targeting bacterial systems that remediate hydroxyl radical damage, including proteins involved in triggering the DNA damage response, e.g., RecA.
Journal ArticleDOI
Physiological heterogeneity in biofilms.
TL;DR: The processes that generate chemical gradients inBiofilms, the genetic and physiological responses of the bacteria as they adapt to these gradients and the techniques that can be used to visualize and measure the microscale physiological heterogeneities of bacteria in biofilms are discussed.
Journal ArticleDOI
How antibiotics kill bacteria: from targets to networks
TL;DR: The multilayered effects of drug–target interactions, including the essential cellular processes that are inhibited by bactericidal antibiotics and the associated cellular response mechanisms that contribute to killing are discussed.
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