Biochemistry of arsenic detoxification
TLDR
While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.About:
This article is published in FEBS Letters.The article was published on 2002-10-02 and is currently open access. It has received 726 citations till now. The article focuses on the topics: Arsenate reductase activity & Arsenate reductase.read more
Citations
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The Ecology of Arsenic
Ronald S. Oremland,John F. Stolz +1 more
TL;DR: This work reviews what is known about arsenic-metabolizing bacteria and their potential impact on speciation and mobilization of arsenic in nature and investigates their role in aquifers.
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Wound healing - A literature review.
Ana Cristina Gonzalez,Tila Fortuna Costa,Zilton A. Andrade,Alena Ribeiro Alves Peixoto Medrado +3 more
TL;DR: The purpose of this review is to describe the various cellular and molecular aspects involved in the skin healing process.
Journal ArticleDOI
Arsenic hazards: strategies for tolerance and remediation by plants
Rudra Deo Tripathi,Sudhakar Srivastava,Seema Mishra,Nandita Singh,Rakesh Tuli,Dharmendra K. Gupta,Frans J. M. Maathuis +6 more
TL;DR: Recent advances in arsenic tolerance are discussed and their potential applications, particularly in the context of multigenic engineering approaches, are discussed.
Journal ArticleDOI
Arsenic binding to proteins.
TL;DR: Although the adverse health effects arising from exposure to arsenic have been well-recognized, the mechanism(s) of action responsible for the diverse range of health effects are complicated and poorly understood.
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Occurrence of arsenic contamination in Canada: sources, behavior and distribution.
TL;DR: An analysis of the currently available information on recognized problem areas, and an overview of current knowledge of the principal hydrogeochemical processes of arsenic transportation and transformation are provided, however, a more detailed understanding of local sources of arsenic and mechanisms of arsenic release is required.
References
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Journal Article
Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells.
Susan P.C. Cole,Kathryn E. Sparks,Karen Fraser,Douglas W. Loe,Caroline E. Grant,Gerald M. Wilson,Roger G. Deeley +6 more
TL;DR: Transfecting two different eukaryotic expression vectors containing MRP complementary DNA into HeLa cells to study the pharmacological phenotype produced exclusively by overexpression of human MRP indicates that drug-resistant cell lines generated by transfection with MRp complementary DNA display some but not all of the characteristics of MRP-overexpressing cell lines produced by drug selection in vitro.
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Cellular and molecular biology of the aquaporin water channels.
TL;DR: The high water permeability characteristic of mammalian red cell membranes is now known to be caused by the protein AQP1, a tetramer with each subunit containing an aqueous pore likened to an hourglass formed by obversely arranged tandem repeats.
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Microbial arsenic: from geocycles to genes and enzymes.
TL;DR: The DNA sequencing and protein crystal structures have established the convergent evolution of three classes of arsenate reductases, which involve three cysteine thiols and S-As bond intermediates, so convergence evolution to similar mechanisms has taken place.
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Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein
Guido J.R. Zaman,Jan Lankelma,O. van Tellingen,Jos H. Beijnen,Henk L. Dekker,Coen C. Paulusma,R.P.J. Oude Elferink,Frank Baas,Piet Borst +8 more
TL;DR: It is demonstrated that depletion of intracellular glutathione by DL-buthionine (S,R)-sulfoximine results in a complete reversal of resistance to doxorubicin, daunorubICin, vincristine, and VP-16 in lung carcinoma cells transfected with a MRP cDNA expression vector, and this results support the hypothesis that MRP functions as a glutATHione S-conjugate carrier.
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Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9
TL;DR: The results suggest that AQP9 and AQP7 may be a major routes of arsenite uptake into mammalian cells, an observation potentially of large importance for understanding the action of arsenic as a human toxin and carcinogen, as well as its efficacy as a chemotherapeutic agent for acute promyelocytic leukemia.