Biochemistry of arsenic detoxification
TLDR
While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.About:
This article is published in FEBS Letters.The article was published on 2002-10-02 and is currently open access. It has received 726 citations till now. The article focuses on the topics: Arsenate reductase activity & Arsenate reductase.read more
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Synergistic interaction of glyceraldehydes-3-phosphate dehydrogenase and ArsJ, a novel organoarsenical efflux permease, confers arsenate resistance
TL;DR: It is proposed that ArsJ is an efflux permease that extrudes 1As3 PGA from cells, where it rapidly dissociates into As(V) and 3‐phosphoglycerate (3PGA), creating a novel pathway of arsenate resistance.
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Identification of an Arsenic Resistance and Arsenic-Sensing System in Campylobacter jejuni
TL;DR: The ars operon is identified as an important mechanism for arsenic resistance and sensing in Campylobacter and is subject to regulation by ArsR, which directly binds to the ars promoter and inhibits the transcription of the operon.
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Characterization of Nitrate-Dependent As(III)-Oxidizing Communities in Arsenic-Contaminated Soil and Investigation of Their Metabolic Potentials by the Combination of DNA-Stable Isotope Probing and Metagenomics.
Miaomiao Zhang,Zhe Li,Zhe Li,Max M. Häggblom,Lily Y. Young,Zijun He,Fangbai Li,Rui Xu,Xiaoxu Sun,Weimin Sun +9 more
TL;DR: DNA-stable isotope probing with 13C-labelled NaHCO3 as the sole carbon source, amplicon sequencing, and shotgun metagenomics were combined to identify NDAB and investigate their NDAO metabolism, suggesting the proof-of-concept of using DNA-SIP to identify the slow-growing NDABs.
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Characterization of arsenic-resistant bacteria from the rhizosphere of arsenic hyperaccumulator Pteris vittata
TL;DR: The results suggested that these arsenic-resistant bacteria are metabolically adapted to arsenic-induced osmotic or oxidative stresses in addition to the specific bacterial system to exclude cellular arsenic, which contribute to the high arsenic resistance in the bacterial isolates.
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Temporal transcriptomic response during arsenic stress in Herminiimonas arsenicoxydans
Jessica Cleiss-Arnold,Sandrine Koechler,Caroline Proux,Marie-Laure Fardeau,Marie-Agnès Dillies,Jean-Yves Coppée,Florence Arsène-Ploetze,Philippe N. Bertin +7 more
TL;DR: Gene expression patterns suggest that the exposure to As( III) induces an acute response to rapidly minimize the immediate effects of As(III).
References
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Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.
TL;DR: Related sequences in both alpha and beta and in other enzymes that bind ATP or ADP in catalysis help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.
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CLUSTAL: A package for performing multiple sequence alignment on a microcomputer
Desmond G. Higgins,Paul M. Sharp +1 more
TL;DR: An approach for performing multiple alignments of large numbers of amino acid or nucleotide sequences is described, based on first deriving a phylogenetic tree from a matrix of all pairwise sequence similarity scores obtained using a fast pairwise alignment algorithm.
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Classification and evolution of P-loop GTPases and related ATPases.
TL;DR: In this article, the authors compared sequences and available structures for all the widely distributed representatives of the P-loop GTPases and GTPase-related proteins with the aim of constructing an evolutionary classification for this superclass of proteins and reconstructing the principal events in their evolution.
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Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells.
Miroslav Styblo,L.M. Del Razo,Libia Vega,Dori R. Germolec,Edward L. LeCluyse,G. Hamilton,W Reed,Changqing Wang,William R. Cullen,David J. Thomas +9 more
TL;DR: It is suggested that trivalent methylated arsenicals, intermediary products of arsenic methylation, may significantly contribute to the adverse effects associated with exposure to iAs, and high methylation capacity does not protect cells from the acute toxicity of triavalent arsenicals.
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The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
Inka Leier,Gabriele Jedlitschky,Ulrike Buchholz,Susan P.C. Cole,Roger G. Deeley,Dietrich Keppler +5 more
TL;DR: It is concluded that the biosynthetic release of LTC4 from cells is mediated by the 190-kDa product of the MRP gene, a primary-active ATP-dependent export pump for conjugates of lipophilic compounds with glutathione and several other anionic residues.