Biochemistry of arsenic detoxification
TLDR
While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.About:
This article is published in FEBS Letters.The article was published on 2002-10-02 and is currently open access. It has received 726 citations till now. The article focuses on the topics: Arsenate reductase activity & Arsenate reductase.read more
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Pyridine-2,6-bis(thiocarboxylic acid) produced by Pseudomonas stutzeri KC reduces chromium(VI) and precipitates mercury, cadmium, lead and arsenic
TL;DR: A novel role of pdtc is postulated as its involvement in providing an extracellular pool of thiols that are used for redox processes in detoxification of the bacterial Extracellular environment can be mediated by transition metal:pdtc complexes.
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Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line
Shannon M. Matulis,Alejo A. Morales,Lucy Yehiayan,Claire Croutch,Delia Gutman,Yong Cai,Kelvin P. Lee,Lawrence H. Boise +7 more
TL;DR: Treatment of an arsenic trioxide-resistant myeloma cell line with darinaparsin resulted in dose-dependent apoptosis, indicating that cross-resistance does not necessarily develop between these two forms of arsenic in multiple myELoma cell lines.
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Comparative Genomic Analysis of Lactobacillus plantarum: An Overview.
TL;DR: The results suggest that there is a high rate of transfer of genetic material between the strains, and the strains may be useful for the biotechnology, bioremediation, and production of bacteriocins.
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Arsenic-related microorganisms in groundwater: a review on distribution, metabolic activities and potential use in arsenic removal processes
Simona Crognale,Stefano Amalfitano,Barbara Casentini,Stefano Fazi,Maurizio Petruccioli,Simona Rossetti +5 more
TL;DR: In this paper, a review of the existing knowledge about ecology, biochemistry and genomics of arsenic-related microorganisms, with particular reference to their distribution and their capabilities to oxidize As(III) in groundwater is provided.
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Arginine 60 in the ArsC arsenate reductase of E. coli plasmid R773 determines the chemical nature of the bound As(III) product.
TL;DR: It is proposed that this intermediate of ArsC is more stable than the monohydroxyl Cys 12‐thiol‐dihydroxyarsenite intermediate of the native enzyme, resulting in slow release of product and, consequently, loss of activity.
References
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Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.
TL;DR: Related sequences in both alpha and beta and in other enzymes that bind ATP or ADP in catalysis help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.
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CLUSTAL: A package for performing multiple sequence alignment on a microcomputer
Desmond G. Higgins,Paul M. Sharp +1 more
TL;DR: An approach for performing multiple alignments of large numbers of amino acid or nucleotide sequences is described, based on first deriving a phylogenetic tree from a matrix of all pairwise sequence similarity scores obtained using a fast pairwise alignment algorithm.
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Classification and evolution of P-loop GTPases and related ATPases.
TL;DR: In this article, the authors compared sequences and available structures for all the widely distributed representatives of the P-loop GTPases and GTPase-related proteins with the aim of constructing an evolutionary classification for this superclass of proteins and reconstructing the principal events in their evolution.
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Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells.
Miroslav Styblo,L.M. Del Razo,Libia Vega,Dori R. Germolec,Edward L. LeCluyse,G. Hamilton,W Reed,Changqing Wang,William R. Cullen,David J. Thomas +9 more
TL;DR: It is suggested that trivalent methylated arsenicals, intermediary products of arsenic methylation, may significantly contribute to the adverse effects associated with exposure to iAs, and high methylation capacity does not protect cells from the acute toxicity of triavalent arsenicals.
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The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
Inka Leier,Gabriele Jedlitschky,Ulrike Buchholz,Susan P.C. Cole,Roger G. Deeley,Dietrich Keppler +5 more
TL;DR: It is concluded that the biosynthetic release of LTC4 from cells is mediated by the 190-kDa product of the MRP gene, a primary-active ATP-dependent export pump for conjugates of lipophilic compounds with glutathione and several other anionic residues.