Biochemistry of arsenic detoxification
TLDR
While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.About:
This article is published in FEBS Letters.The article was published on 2002-10-02 and is currently open access. It has received 726 citations till now. The article focuses on the topics: Arsenate reductase activity & Arsenate reductase.read more
Citations
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Microbes involved in arsenic mobilization and respiration: a review on isolation, identification, isolates and implications
TL;DR: The study indicates that there is an exigent need to have a clear understanding of environmental aspects of As mobilization and subsequent oxidation–reduction by a suitable microbial consortium.
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Availability of arsenic in human milk in women and its correlation with arsenic in urine of breastfed children living in arsenic contaminated areas in Bangladesh
Rafiqul Islam,John Attia,Mohammad Alauddin,Mark McEvoy,Patrick McElduff,Christine Slater,Monirul Islam,Ayesha Akhter,Catherine D'Este,Roseanne Peel,Shahnaz Akter,Wayne Smith,Stephen Begg,Abul Hasnat Milton +13 more
TL;DR: A low arsenic concentration in human milk was observed, lower than the World Health Organization’s maximum permissible limit (WHO Permissible Limit 15 μg/kg-bw/week) and support the safety of breastfeeding even in arsenic contaminated areas.
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Isolation and characterization of yeasts associated with plants growing in heavy-metal- and arsenic-contaminated soils
Juan Ramos-Garza,Rafael Bustamante-Brito,Gabriela Ángeles de Paz,Ma. Gabriela Medina-Canales,María Soledad Vásquez-Murrieta,En Tao Wang,Aída Verónica Rodríguez-Tovar +6 more
TL;DR: This is the first study on the abundance and identification of rhizosphere yeasts in a heavy-metal- and arsenic-contaminated soil, and of the reduction of arsenate by the species C. albidus.
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Speciation of Arsenic in Euglena gracilis Cells Exposed to As(V)
Jennyfer Miot,Guillaume Morin,Fériel Skouri-Panet,Céline Férard,Antonine Poitevin,Emmanuel Aubry,G. Ona-Nguema,Farid Juillot,François Guyot,Gordon E. Brown +9 more
TL;DR: Intracellular As(V) is found to be exclusively concentrated in the membrane + nucleus fraction, suggesting that arsenate could substitute for phosphate groups in membranes or in phosphate-containing macromolecules, and arsenic species are partitioned.
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Facile reduction of arsenate in methanogenic sludge.
Jim A. Field,Reyes Sierra-Alvarez,Irail Cortinas,Gumersindo Feijoo,Gumersindo Feijoo,Maria Teresa Moreira,Maria Teresa Moreira,Mike Kopplin,A. Jay Gandolfi +8 more
TL;DR: The results taken as a whole suggest that arsenate disposed into anaerobic environments may readily be converted to arsenite increasing the mobility of arsenic.
References
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Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.
TL;DR: Related sequences in both alpha and beta and in other enzymes that bind ATP or ADP in catalysis help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.
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CLUSTAL: A package for performing multiple sequence alignment on a microcomputer
Desmond G. Higgins,Paul M. Sharp +1 more
TL;DR: An approach for performing multiple alignments of large numbers of amino acid or nucleotide sequences is described, based on first deriving a phylogenetic tree from a matrix of all pairwise sequence similarity scores obtained using a fast pairwise alignment algorithm.
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Classification and evolution of P-loop GTPases and related ATPases.
TL;DR: In this article, the authors compared sequences and available structures for all the widely distributed representatives of the P-loop GTPases and GTPase-related proteins with the aim of constructing an evolutionary classification for this superclass of proteins and reconstructing the principal events in their evolution.
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Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells.
Miroslav Styblo,L.M. Del Razo,Libia Vega,Dori R. Germolec,Edward L. LeCluyse,G. Hamilton,W Reed,Changqing Wang,William R. Cullen,David J. Thomas +9 more
TL;DR: It is suggested that trivalent methylated arsenicals, intermediary products of arsenic methylation, may significantly contribute to the adverse effects associated with exposure to iAs, and high methylation capacity does not protect cells from the acute toxicity of triavalent arsenicals.
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The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
Inka Leier,Gabriele Jedlitschky,Ulrike Buchholz,Susan P.C. Cole,Roger G. Deeley,Dietrich Keppler +5 more
TL;DR: It is concluded that the biosynthetic release of LTC4 from cells is mediated by the 190-kDa product of the MRP gene, a primary-active ATP-dependent export pump for conjugates of lipophilic compounds with glutathione and several other anionic residues.