Biochemistry of arsenic detoxification
TLDR
While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.About:
This article is published in FEBS Letters.The article was published on 2002-10-02 and is currently open access. It has received 726 citations till now. The article focuses on the topics: Arsenate reductase activity & Arsenate reductase.read more
Citations
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DMSO Reductase Family: Phylogenetics and Applications of Extremophiles.
Jose María Miralles-Robledillo,Javier Torregrosa-Crespo,Rosa María Martínez-Espinosa,Carmen Pire +3 more
TL;DR: A deep revision of the literature reported on DMSO as well as the use of bioinformatics tools and free software has been developed in order to highlight the relevance of D MSO reductases on anaerobic processes connected to different biogeochemical cycles.
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Phytochelatin synthesis in Dunaliella salina induced by arsenite and arsenate under various phosphate regimes
TL;DR: Overall, the data demonstrated that the production of GSH and PCs was affected by PO43- and that these thiols played an important role in As detoxification by D. salina under different extracellularPO43- regimes.
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AsChip: A High-Throughput qPCR Chip for Comprehensive Profiling of Genes Linked to Microbial Cycling of Arsenic.
Yi Zhao,Jian-Qiang Su,Jun Ye,Christopher Rensing,Christopher Rensing,Stacie Tardif,Yong-Guan Zhu,Kristian K. Brandt +7 more
TL;DR: The development of a novel high-throughput qPCR (HT-qPCR) chip (AsChip) for comprehensive profiling of genes involved in microbial As cycling and results indicate that AsChip constitutes a robust tool for comprehensive quantitative profiling of As genes in environmental samples.
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Cyanobacteria produce arsenosugars
TL;DR: In this article, the authors used a high-performance liquid chromatography-inductively coupled plasma mass spectrometry system to analyze the arsenate incorporation in axenic cultures of the freshwater cyanobacteria Synechocystis sp. PCC 6803 and Nostoc (Anabaena) sp.PCC 7120 and found that both strains have an ability to biotransform arsenate into oxo-arsenosugar-glycerol within 20min through reduction of incorporated arsenate to arsenite and methylation of produced arsenite to dimethyl
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Arsenic mobilization in a high arsenic groundwater revealed by metagenomic and Geochip analyses.
TL;DR: The composition and function of microbial community and reconstructed genome bins suggest that high level of arsenite in the groundwater may be attributed to arsenate release from iron oxides reductive dissolution by the iron-reducing bacteria, and subsequent arsenate reduction by ammonia-producing bacteria featuring ars operon.
References
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Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.
TL;DR: Related sequences in both alpha and beta and in other enzymes that bind ATP or ADP in catalysis help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.
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CLUSTAL: A package for performing multiple sequence alignment on a microcomputer
Desmond G. Higgins,Paul M. Sharp +1 more
TL;DR: An approach for performing multiple alignments of large numbers of amino acid or nucleotide sequences is described, based on first deriving a phylogenetic tree from a matrix of all pairwise sequence similarity scores obtained using a fast pairwise alignment algorithm.
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Classification and evolution of P-loop GTPases and related ATPases.
TL;DR: In this article, the authors compared sequences and available structures for all the widely distributed representatives of the P-loop GTPases and GTPase-related proteins with the aim of constructing an evolutionary classification for this superclass of proteins and reconstructing the principal events in their evolution.
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Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells.
Miroslav Styblo,L.M. Del Razo,Libia Vega,Dori R. Germolec,Edward L. LeCluyse,G. Hamilton,W Reed,Changqing Wang,William R. Cullen,David J. Thomas +9 more
TL;DR: It is suggested that trivalent methylated arsenicals, intermediary products of arsenic methylation, may significantly contribute to the adverse effects associated with exposure to iAs, and high methylation capacity does not protect cells from the acute toxicity of triavalent arsenicals.
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The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
Inka Leier,Gabriele Jedlitschky,Ulrike Buchholz,Susan P.C. Cole,Roger G. Deeley,Dietrich Keppler +5 more
TL;DR: It is concluded that the biosynthetic release of LTC4 from cells is mediated by the 190-kDa product of the MRP gene, a primary-active ATP-dependent export pump for conjugates of lipophilic compounds with glutathione and several other anionic residues.