Biochemistry of arsenic detoxification
TLDR
While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.About:
This article is published in FEBS Letters.The article was published on 2002-10-02 and is currently open access. It has received 726 citations till now. The article focuses on the topics: Arsenate reductase activity & Arsenate reductase.read more
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Dissertation
Expression and structural investigation of acid tolerant arsenite oxidase with biosensor potential
TL;DR: When Aio was incorporated in biosensor construction, the DCPIP/Aio electrochemical assay was capable of detecting 10 to 500 ppb As(III) by using carbon screen printed electrode, revealing the potential of Aio as a biosensing material for determining safe level of As( III) in water systems.
Journal ArticleDOI
Arsenic pollution and arsenic-resistant bacteria of drying Urmia Salt Lake
TL;DR: In this article , the authors attempted to isolate and characterize arsenic-resistant bacteria from the drying Urmia lake, and six arsenic resistant strains were identified as the members of Shouchella, Salipaludibacillus, and Evansella genera.
Dissertation
An investigation into the arsenic resistance genes of Leptospirillum ferriphilum
TL;DR: The arsenic resistance genes of Leptospirillum ferriphilum strain Fairview were investigated and compared these genes to the ars genes from other Leptonospirilli and it was shown that the TnLfArs is capable of transposition in Escherichia coli.
and sensitivity in leukemia cells Relationship of expression of aquaglyceroporin 9 with arsenic uptake
TL;DR: This paper aims to provide a history of neoplasia in the clinic and some of the techniques used to treat the disease and provide information on how to identify and treat these disorders.
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A PadR family transcriptional repressor controls transcription of a trivalent metalloid resistance operon of Azospirillum halopraeferens strain Au 4.
TL;DR: PadRars represents a new type of repressor proteins regulating transcription of an ars operon involved in the resistance to trivalent metalloids, especially MAs(III).
References
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Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.
TL;DR: Related sequences in both alpha and beta and in other enzymes that bind ATP or ADP in catalysis help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.
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CLUSTAL: A package for performing multiple sequence alignment on a microcomputer
Desmond G. Higgins,Paul M. Sharp +1 more
TL;DR: An approach for performing multiple alignments of large numbers of amino acid or nucleotide sequences is described, based on first deriving a phylogenetic tree from a matrix of all pairwise sequence similarity scores obtained using a fast pairwise alignment algorithm.
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Classification and evolution of P-loop GTPases and related ATPases.
TL;DR: In this article, the authors compared sequences and available structures for all the widely distributed representatives of the P-loop GTPases and GTPase-related proteins with the aim of constructing an evolutionary classification for this superclass of proteins and reconstructing the principal events in their evolution.
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Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells.
Miroslav Styblo,L.M. Del Razo,Libia Vega,Dori R. Germolec,Edward L. LeCluyse,G. Hamilton,W Reed,Changqing Wang,William R. Cullen,David J. Thomas +9 more
TL;DR: It is suggested that trivalent methylated arsenicals, intermediary products of arsenic methylation, may significantly contribute to the adverse effects associated with exposure to iAs, and high methylation capacity does not protect cells from the acute toxicity of triavalent arsenicals.
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The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
Inka Leier,Gabriele Jedlitschky,Ulrike Buchholz,Susan P.C. Cole,Roger G. Deeley,Dietrich Keppler +5 more
TL;DR: It is concluded that the biosynthetic release of LTC4 from cells is mediated by the 190-kDa product of the MRP gene, a primary-active ATP-dependent export pump for conjugates of lipophilic compounds with glutathione and several other anionic residues.