Biochemistry of arsenic detoxification
TLDR
While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.About:Â
This article is published in FEBS Letters.The article was published on 2002-10-02 and is currently open access. It has received 726 citations till now. The article focuses on the topics: Arsenate reductase activity & Arsenate reductase.read more
Citations
More filters
Journal ArticleDOI
Arsenic trioxide uptake by human and rat aquaglyceroporins.
TL;DR: The hypothesis that arsenic trioxide and glycerol use the same translocation pathway in AQP9 is supported.
Journal ArticleDOI
Novel Pathway for Arsenic Detoxification in the Legume Symbiont Sinorhizobium meliloti
TL;DR: The results imply that, when S. meliloti is exposed to environmental arsenate, arsenate enters the cell through phosphate transport systems and is reduced to arsenite by ArsC, which is the first report of an aquaglyceroporin with a physiological function in arsenic resistance.
Journal ArticleDOI
Sequence analysis of three plasmids harboured in Rhodococcus erythropolis strain PR4.
Mitsuo Sekine,Satoshi Tanikawa,Seiha Omata,Mika Saito,Takatomo Fujisawa,Naofumi Tsukatani,Takahisa Tajima,Tomohiro Sekigawa,Hiroki Kosugi,Yasunori Matsuo,Rika Nishiko,Kohsuke Imamura,Mio Ito,Hitomi Narita,Shin-ichi Tago,Nobuyuki Fujita,Shigeaki Harayama +16 more
TL;DR: Joint actions of enzymes encoded by pREL1 and pREC1 may enable efficient mineralization of alkanes in Rhodococcus erythropolis strain PR4.
Journal ArticleDOI
Evidence of hemoglobin binding to arsenic as a basis for the accumulation of arsenic in rat blood.
Meiling Lu,Hailin Wang,Xing-Fang Li,Xiufen Lu,William R. Cullen,Lora L. Arnold,Samuel M. Cohen,X. Chris Le +7 more
TL;DR: Four trivalent arsenic species, inorganic arsenite, monomethylarsonous acid, MMA, dimethylarsinous acid, and DMA(III), are suggested to be responsible for the accumulation of arsenic in rat blood.
Journal ArticleDOI
Whole-Genome Analysis of the Methyl tert-Butyl Ether-Degrading Beta-Proteobacterium Methylibium petroleiphilum PM1
Staci R. Kane,Anu Chakicherla,Patrick S. G. Chain,Patrick S. G. Chain,Radomir Schmidt,Maria W. Shin,Tina C. Legler,Kate M. Scow,Frank W. Larimer,Frank W. Larimer,Susan Lucas,Paul G. Richardson,Krassimira R. Hristova +12 more
TL;DR: A recent whole-genome analysis of PM1 revealed an approximately 4-Mb circular chromosome and an approximately 600-kb megaplasmid, containing 3,831 and 646 genes, respectively as discussed by the authors.
References
More filters
Journal ArticleDOI
Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.
TL;DR: Related sequences in both alpha and beta and in other enzymes that bind ATP or ADP in catalysis help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.
Journal ArticleDOI
CLUSTAL: A package for performing multiple sequence alignment on a microcomputer
Desmond G. Higgins,Paul M. Sharp +1 more
TL;DR: An approach for performing multiple alignments of large numbers of amino acid or nucleotide sequences is described, based on first deriving a phylogenetic tree from a matrix of all pairwise sequence similarity scores obtained using a fast pairwise alignment algorithm.
Journal ArticleDOI
Classification and evolution of P-loop GTPases and related ATPases.
TL;DR: In this article, the authors compared sequences and available structures for all the widely distributed representatives of the P-loop GTPases and GTPase-related proteins with the aim of constructing an evolutionary classification for this superclass of proteins and reconstructing the principal events in their evolution.
Journal ArticleDOI
Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells.
Miroslav Styblo,L.M. Del Razo,Libia Vega,Dori R. Germolec,Edward L. LeCluyse,G. Hamilton,W Reed,Changqing Wang,William R. Cullen,David J. Thomas +9 more
TL;DR: It is suggested that trivalent methylated arsenicals, intermediary products of arsenic methylation, may significantly contribute to the adverse effects associated with exposure to iAs, and high methylation capacity does not protect cells from the acute toxicity of triavalent arsenicals.
Journal ArticleDOI
The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
Inka Leier,Gabriele Jedlitschky,Ulrike Buchholz,Susan P.C. Cole,Roger G. Deeley,Dietrich Keppler +5 more
TL;DR: It is concluded that the biosynthetic release of LTC4 from cells is mediated by the 190-kDa product of the MRP gene, a primary-active ATP-dependent export pump for conjugates of lipophilic compounds with glutathione and several other anionic residues.