Biochemistry of arsenic detoxification
TLDR
While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.About:
This article is published in FEBS Letters.The article was published on 2002-10-02 and is currently open access. It has received 726 citations till now. The article focuses on the topics: Arsenate reductase activity & Arsenate reductase.read more
Citations
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Journal ArticleDOI
The ins and outs of metal homeostasis by the root nodule actinobacterium Frankia.
Teal Furnholm,Louis S. Tisa +1 more
TL;DR: Each strain had a unique combination of metal import, binding, modification, and export genes that explain differences in patterns of metal resistance between strains.
Journal ArticleDOI
Characterization, real-time quantification and in silico modeling of arsenate reductase (arsC) genes in arsenic-resistant Herbaspirillum sp. GW103
TL;DR: This study investigated the mechanism of arsenic resistance in the diazotrophic bacterium Herbaspirillum sp.
Journal ArticleDOI
Functional Profiling Identifies Determinants of Arsenic Trioxide Cellular Toxicity
Amin Sobh,Amin Sobh,Alex Loguinov,Gulce Naz Yazici,Gulce Naz Yazici,Rola S Zeidan,Abderrahmane Tagmount,Nima S. Hejazi,Alan Hubbard,Luoping Zhang,Chris D. Vulpe,Chris D. Vulpe +11 more
TL;DR: A genome-wide CRISPR-based approach to identify modulators of AsIII toxicity in K562, a human CML cell line found that disruption of KEAP1, the inhibitory partner of the key antioxidant transcription factor Nrf2, or TXNDC17, a thioredoxin-like protein, markedly increased AsIII tolerance.
Journal ArticleDOI
Coregulated Genes Link Sulfide:Quinone Oxidoreductase and Arsenic Metabolism in Synechocystis sp. Strain PCC6803
Csaba István Nagy,Imre Vass,Gábor Rákhely,I. Vass,András Tóth,András Tóth,Ágnes Duzs,Loredana Peca,Jerzy Kruk,Péter B. Kós,Péter B. Kós +10 more
TL;DR: It is proposed that the proteins encoded by the suoRSCT operon might have played an important role under anaerobic, reducing conditions on primordial Earth and that the operon was acquired by the cyanobacterium via horizontal gene transfer.
Book ChapterDOI
Microbial Interactions in the Arsenic Cycle: Adoptive Strategies and Applications in Environmental Management
TL;DR: This review has addressed and emphasized the impact of different microbial processes (e.g., arsenite oxidation, cytoplasmic arsenite reduction, respiratory arsenate reduction, arsenite methylation) on the arsenic cycle.
References
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Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.
TL;DR: Related sequences in both alpha and beta and in other enzymes that bind ATP or ADP in catalysis help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.
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CLUSTAL: A package for performing multiple sequence alignment on a microcomputer
Desmond G. Higgins,Paul M. Sharp +1 more
TL;DR: An approach for performing multiple alignments of large numbers of amino acid or nucleotide sequences is described, based on first deriving a phylogenetic tree from a matrix of all pairwise sequence similarity scores obtained using a fast pairwise alignment algorithm.
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Classification and evolution of P-loop GTPases and related ATPases.
TL;DR: In this article, the authors compared sequences and available structures for all the widely distributed representatives of the P-loop GTPases and GTPase-related proteins with the aim of constructing an evolutionary classification for this superclass of proteins and reconstructing the principal events in their evolution.
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Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells.
Miroslav Styblo,L.M. Del Razo,Libia Vega,Dori R. Germolec,Edward L. LeCluyse,G. Hamilton,W Reed,Changqing Wang,William R. Cullen,David J. Thomas +9 more
TL;DR: It is suggested that trivalent methylated arsenicals, intermediary products of arsenic methylation, may significantly contribute to the adverse effects associated with exposure to iAs, and high methylation capacity does not protect cells from the acute toxicity of triavalent arsenicals.
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The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
Inka Leier,Gabriele Jedlitschky,Ulrike Buchholz,Susan P.C. Cole,Roger G. Deeley,Dietrich Keppler +5 more
TL;DR: It is concluded that the biosynthetic release of LTC4 from cells is mediated by the 190-kDa product of the MRP gene, a primary-active ATP-dependent export pump for conjugates of lipophilic compounds with glutathione and several other anionic residues.