Biochemistry of arsenic detoxification
TLDR
While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.About:
This article is published in FEBS Letters.The article was published on 2002-10-02 and is currently open access. It has received 726 citations till now. The article focuses on the topics: Arsenate reductase activity & Arsenate reductase.read more
Citations
More filters
Journal ArticleDOI
Molecular identification of arsenic-resistant estuarine bacteria and characterization of their ars genotype
M. Sri Lakshmi Sunita,S. Prashant,P. V. Bramha Chari,S. Nageswara Rao,Padma Balaravi,P. B. Kavi Kishor +5 more
TL;DR: In the present study, 44 arsenic-resistant bacteria were isolated through serial dilutions on agar plate from Mandovi and Zuari—estuarine water systems and characterization of their ars genes might be useful to develop efficient arsenic detoxification strategies for arsenic contaminated aquifers.
Journal ArticleDOI
Enhanced arsenate uptake in Saccharomyces cerevisiae overexpressing the Pho84 phosphate transporter.
TL;DR: Saccharomyces cerevisiae was engineered as a potential biosorbent for enhanced arsenate accumulation and may no longer be a limiting factor in the engineered system and further increases should be possible by upregulating the downstream reduction and sequestration pathways.
Journal ArticleDOI
Antimicrobial resistance due to the content of potentially toxic metals in soil and fertilizing products.
TL;DR: There is a genetic linkage or direct genetic causality between genetic determinants to these widely divergent antimicrobials, and metal resistance.
Journal ArticleDOI
Exposure of Lemna minor to arsenite: expression levels of the components and intermediates of the ubiquitin/proteasome pathway.
Cláudia N. Santos,Margarida M. Gaspar,Ana Caeiro,Cristina Branco-Price,Cristina Branco-Price,Artur R. Teixeira,Ricardo B. Ferreira,Ricardo B. Ferreira +7 more
TL;DR: This study is the first report on the involvement of the ubiquitin/proteasome pathway in response to arsenite in plants and addresses the simultaneous expression of selected genes encoding the various components of the pathway.
Journal ArticleDOI
Arsenate reduction and expression of multiple chromosomal ars operons in Geobacillus kaustophilus A1.
TL;DR: A mechanism for regulation of As(V) detoxification by Geobacillus that is both consistent with the findings and relevant to the biogeochemical cycle of arsenic and its mobility in the environment is proposed.
References
More filters
Journal ArticleDOI
Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.
TL;DR: Related sequences in both alpha and beta and in other enzymes that bind ATP or ADP in catalysis help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.
Journal ArticleDOI
CLUSTAL: A package for performing multiple sequence alignment on a microcomputer
Desmond G. Higgins,Paul M. Sharp +1 more
TL;DR: An approach for performing multiple alignments of large numbers of amino acid or nucleotide sequences is described, based on first deriving a phylogenetic tree from a matrix of all pairwise sequence similarity scores obtained using a fast pairwise alignment algorithm.
Journal ArticleDOI
Classification and evolution of P-loop GTPases and related ATPases.
TL;DR: In this article, the authors compared sequences and available structures for all the widely distributed representatives of the P-loop GTPases and GTPase-related proteins with the aim of constructing an evolutionary classification for this superclass of proteins and reconstructing the principal events in their evolution.
Journal ArticleDOI
Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells.
Miroslav Styblo,L.M. Del Razo,Libia Vega,Dori R. Germolec,Edward L. LeCluyse,G. Hamilton,W Reed,Changqing Wang,William R. Cullen,David J. Thomas +9 more
TL;DR: It is suggested that trivalent methylated arsenicals, intermediary products of arsenic methylation, may significantly contribute to the adverse effects associated with exposure to iAs, and high methylation capacity does not protect cells from the acute toxicity of triavalent arsenicals.
Journal ArticleDOI
The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
Inka Leier,Gabriele Jedlitschky,Ulrike Buchholz,Susan P.C. Cole,Roger G. Deeley,Dietrich Keppler +5 more
TL;DR: It is concluded that the biosynthetic release of LTC4 from cells is mediated by the 190-kDa product of the MRP gene, a primary-active ATP-dependent export pump for conjugates of lipophilic compounds with glutathione and several other anionic residues.