Biochemistry of arsenic detoxification
TLDR
While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.About:
This article is published in FEBS Letters.The article was published on 2002-10-02 and is currently open access. It has received 726 citations till now. The article focuses on the topics: Arsenate reductase activity & Arsenate reductase.read more
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Conference overview: molecular mechanisms of metal toxicity and carcinogenesis.
Jacquelyn J. Bower,Jacquelyn J. Bower,Stephen S. Leonard,Stephen S. Leonard,Xianglin Shi,Xianglin Shi +5 more
TL;DR: Almost 125 scientists attended the 3rd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis and presented the latest research concerning these mechanisms, with major areas of focus included exposure assessment and biomarker identification, roles of ROS and antioxidants in carcinogenesis, and mechanisms of metal-induced DNA damage.
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ArsH from Synechocystis sp. PCC 6803 reduces chromate and ferric iron.
TL;DR: The results suggest that Synechocystis ArsH had no substrate specificities and shared some biochemical properties that other enzymes possessed, and may be involved in coordinating oxidative stress response generated by arsenic.
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Arsenic (+ 3 oxidation state) methyltransferase and the methylation of arsenicals in the invertebrate chordate Ciona intestinalis
David J. Thomas,Gerardo M. Nava,Shi-Ying Cai,Shi-Ying Cai,James L. Boyer,James L. Boyer,Araceli Hernández-Zavala,H. Rex Gaskins,H. Rex Gaskins +8 more
TL;DR: A comparative genomic approach focusing on the invertebrate chordate Ciona intestinalis was used in this paper to investigate the evolution of molecular mechanisms that mediate inorganic arsenic biotransformation.
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Responses to arsenate stress by Comamonas sp. strain CNB-1 at genetic and proteomic levels
TL;DR: Intriguingly, when CNB-1 cells were exposed to arsenate, the transcription of arsPCom and arsCCom was measurable by RT-PCR, but only ArsPCom was detectable at protein level, indicating that these two genes might express functional forms of arsenate reductases.
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An endophytic strain of Methylobacterium sp. increases arsenate tolerance in Acacia farnesiana (L.) Willd: A proteomic approach.
Nemi Alcantara-Martinez,Francisco Figueroa-Martínez,Fernando Rivera-Cabrera,Gerardo Gutierrez-Sanchez,Tania Volke-Sepúlveda +4 more
TL;DR: A central role of glutathione in the As-tolerance is indicated, and the participation of plant proteins, such as a translation inhibitor and proteins involved in protein folding (immunophilins), which were upregulated by the bacterium are indicated.
References
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Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.
TL;DR: Related sequences in both alpha and beta and in other enzymes that bind ATP or ADP in catalysis help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.
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CLUSTAL: A package for performing multiple sequence alignment on a microcomputer
Desmond G. Higgins,Paul M. Sharp +1 more
TL;DR: An approach for performing multiple alignments of large numbers of amino acid or nucleotide sequences is described, based on first deriving a phylogenetic tree from a matrix of all pairwise sequence similarity scores obtained using a fast pairwise alignment algorithm.
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Classification and evolution of P-loop GTPases and related ATPases.
TL;DR: In this article, the authors compared sequences and available structures for all the widely distributed representatives of the P-loop GTPases and GTPase-related proteins with the aim of constructing an evolutionary classification for this superclass of proteins and reconstructing the principal events in their evolution.
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Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells.
Miroslav Styblo,L.M. Del Razo,Libia Vega,Dori R. Germolec,Edward L. LeCluyse,G. Hamilton,W Reed,Changqing Wang,William R. Cullen,David J. Thomas +9 more
TL;DR: It is suggested that trivalent methylated arsenicals, intermediary products of arsenic methylation, may significantly contribute to the adverse effects associated with exposure to iAs, and high methylation capacity does not protect cells from the acute toxicity of triavalent arsenicals.
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The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
Inka Leier,Gabriele Jedlitschky,Ulrike Buchholz,Susan P.C. Cole,Roger G. Deeley,Dietrich Keppler +5 more
TL;DR: It is concluded that the biosynthetic release of LTC4 from cells is mediated by the 190-kDa product of the MRP gene, a primary-active ATP-dependent export pump for conjugates of lipophilic compounds with glutathione and several other anionic residues.