Biochemistry of arsenic detoxification
TLDR
While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.About:
This article is published in FEBS Letters.The article was published on 2002-10-02 and is currently open access. It has received 726 citations till now. The article focuses on the topics: Arsenate reductase activity & Arsenate reductase.read more
Citations
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Journal ArticleDOI
Arsenic sensing and resistance system in the cyanobacterium Synechocystis sp. strain PCC 6803.
TL;DR: Purified recombinant ArsR protein binds to the arsBHC promoter-operator region in the absence of metals and dissociates from the DNA in the presence of Sb(III) or As(III), suggesting that trivalent metalloids are the true inducers of the system.
Journal ArticleDOI
Comparative genomics of freshwater Fe-oxidizing bacteria: implications for physiology, ecology, and systematics.
David Emerson,Erin K. Field,Olga Chertkov,Karen W. Davenport,Lynne Goodwin,Christine Munk,Matt Nolan,Tanja Woyke +7 more
TL;DR: Multi-locus sequence analysis (MLSA) confirmed the relationship of these two organisms to one another, and indicated they may form a novel order, the Gallionellalaes, within the Betaproteobacteria.
Journal ArticleDOI
A CDC25 homologue from rice functions as an arsenate reductase.
TL;DR: Cloned both OsACR2 genes and expressed them in an Escherichia coli strain in which the arsC gene was deleted and in a yeast strain with a disrupted ACR2 gene, and both exhibited phosphatase activity and arsenate reductase activity.
Book ChapterDOI
The bacterial response to the chalcogen metalloids Se and Te.
TL;DR: The way the chalcogen metalloids Se and Te interact with bacteria is overviewed, attempting to rationalize the considerable amount of literature available on bacterial resistance to the toxic metalloid tellurite and selenite.
Journal ArticleDOI
On the potential of biological treatment for arsenic contaminated soils and groundwater
Suiling Wang,Xiangyu Zhao +1 more
TL;DR: An evaluation on the feasibility of using biological methods for the remediation of arsenic contaminated soils and groundwater gives an evaluation of ex-situ bioleaching and biovolatilization.
References
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Journal ArticleDOI
Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.
TL;DR: Related sequences in both alpha and beta and in other enzymes that bind ATP or ADP in catalysis help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.
Journal ArticleDOI
CLUSTAL: A package for performing multiple sequence alignment on a microcomputer
Desmond G. Higgins,Paul M. Sharp +1 more
TL;DR: An approach for performing multiple alignments of large numbers of amino acid or nucleotide sequences is described, based on first deriving a phylogenetic tree from a matrix of all pairwise sequence similarity scores obtained using a fast pairwise alignment algorithm.
Journal ArticleDOI
Classification and evolution of P-loop GTPases and related ATPases.
TL;DR: In this article, the authors compared sequences and available structures for all the widely distributed representatives of the P-loop GTPases and GTPase-related proteins with the aim of constructing an evolutionary classification for this superclass of proteins and reconstructing the principal events in their evolution.
Journal ArticleDOI
Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells.
Miroslav Styblo,L.M. Del Razo,Libia Vega,Dori R. Germolec,Edward L. LeCluyse,G. Hamilton,W Reed,Changqing Wang,William R. Cullen,David J. Thomas +9 more
TL;DR: It is suggested that trivalent methylated arsenicals, intermediary products of arsenic methylation, may significantly contribute to the adverse effects associated with exposure to iAs, and high methylation capacity does not protect cells from the acute toxicity of triavalent arsenicals.
Journal ArticleDOI
The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
Inka Leier,Gabriele Jedlitschky,Ulrike Buchholz,Susan P.C. Cole,Roger G. Deeley,Dietrich Keppler +5 more
TL;DR: It is concluded that the biosynthetic release of LTC4 from cells is mediated by the 190-kDa product of the MRP gene, a primary-active ATP-dependent export pump for conjugates of lipophilic compounds with glutathione and several other anionic residues.