Biochemistry of arsenic detoxification
TLDR
While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.About:
This article is published in FEBS Letters.The article was published on 2002-10-02 and is currently open access. It has received 726 citations till now. The article focuses on the topics: Arsenate reductase activity & Arsenate reductase.read more
Citations
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Journal ArticleDOI
Expression of the arsenite oxidation regulatory operon in Rhizobium sp. str. NT-26 is under the control of two promoters that respond to different environmental cues.
TL;DR: In silico approach was used to search for other RpoE2 promoters and AioR‐binding motifs and led to the identification of other genes that could be regulated by these proteins including those involved in quorum sensing, chemotaxis, and motility expanding the signaling networks important for the microbial metabolism of arsenite.
Journal ArticleDOI
Multiple resistance mechanisms in Staphylococcus sp. strain AS6 under arsenite stress and its potential use in amelioration of wastewater
TL;DR: In this paper, the multiple metal resistant Staphylococcus sp. strain AS6, isolated from wastewater of Pakistan, was able to resist 25 mM arsenite and 150mM arsenate.
Journal ArticleDOI
Arsenic transformation mediated by gut microbiota affects the fecundity of Caenorhabditis elegans
TL;DR: The results indicated the toxic impact of As(III) and DMAs(V) produced by gut microbes on reproduction of C. elegans, providing novel insight into the interplay between arsenic biotransformation mediated by Gut microbes and the host fecundity in soils.
Book ChapterDOI
Arsenic Contamination in Environment, Ecotoxicological and Health Effects, and Bioremediation Strategies for Its Detoxification
TL;DR: The aim of this chapter is to give an overview of the As contamination in the environment and also the mechanism of removal ofThe As from the contaminated resources by the potent application of plants and microbes.
Journal ArticleDOI
Challenging Xanthomonas campestris with low levels of arsenic mediates cross-protection against oxidant killing.
Karnjana Hrimpeng,Karnjana Hrimpeng,Benjaphorn Prapagdee,Benjaphorn Prapagdee,Peerakan Banjerdkij,Peerakan Banjerdkij,Paiboon Vattanaviboon,James M. Dubbs,Skorn Mongkolsuk,Skorn Mongkolsuk +9 more
TL;DR: Xanthomonas encounters highly toxic reactive oxygen species (ROS) from many sources, such as those generated by plants against invading bacteria, other soil bacteria and from aerobic respiration, and conditions that alter intracellular ROS levels such as exposure to toxic metalloids would have profound effects on bacterial physiology.
References
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Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.
TL;DR: Related sequences in both alpha and beta and in other enzymes that bind ATP or ADP in catalysis help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.
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CLUSTAL: A package for performing multiple sequence alignment on a microcomputer
Desmond G. Higgins,Paul M. Sharp +1 more
TL;DR: An approach for performing multiple alignments of large numbers of amino acid or nucleotide sequences is described, based on first deriving a phylogenetic tree from a matrix of all pairwise sequence similarity scores obtained using a fast pairwise alignment algorithm.
Journal ArticleDOI
Classification and evolution of P-loop GTPases and related ATPases.
TL;DR: In this article, the authors compared sequences and available structures for all the widely distributed representatives of the P-loop GTPases and GTPase-related proteins with the aim of constructing an evolutionary classification for this superclass of proteins and reconstructing the principal events in their evolution.
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Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells.
Miroslav Styblo,L.M. Del Razo,Libia Vega,Dori R. Germolec,Edward L. LeCluyse,G. Hamilton,W Reed,Changqing Wang,William R. Cullen,David J. Thomas +9 more
TL;DR: It is suggested that trivalent methylated arsenicals, intermediary products of arsenic methylation, may significantly contribute to the adverse effects associated with exposure to iAs, and high methylation capacity does not protect cells from the acute toxicity of triavalent arsenicals.
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The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.
Inka Leier,Gabriele Jedlitschky,Ulrike Buchholz,Susan P.C. Cole,Roger G. Deeley,Dietrich Keppler +5 more
TL;DR: It is concluded that the biosynthetic release of LTC4 from cells is mediated by the 190-kDa product of the MRP gene, a primary-active ATP-dependent export pump for conjugates of lipophilic compounds with glutathione and several other anionic residues.